Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function

Autor: Valentina Stolz, Rafael de Freitas e Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Boucheron, Wilfried Ellmeier

Publikováno v: eLife, Vol 13 (2024)

FOXP3+ regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states. Upon NCOR1 deletion in T cells, effector Treg cell frequencies were elev

Externí odkaz: https://doaj.org/article/99b838b47ea54f90b5aa68be8607b3a8

The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells

Autor: Liisa Andersen, Alexandra Franziska Gülich, Marlis Alteneder, Teresa Preglej, Maria Jonah Orola, Narendra Dhele, Valentina Stolz, Alexandra Schebesta, Patricia Hamminger, Anastasiya Hladik, Stefan Floess, Thomas Krausgruber, Thomas Faux, Syed Bilal Ahmad Andrabi, Jochen Huehn, Sylvia Knapp, Tim Sparwasser, Christoph Bock, Asta Laiho, Laura L. Elo, Omid Rasool, Riitta Lahesmaa, Shinya Sakaguchi, Wilfried Ellmeier

Publikováno v: Cell Reports, Vol 29, Iss 13, Pp 4447-4459.e6 (2019)

Summary: Forkhead box protein P3+ (FOXP3+) regulatory T cells (Treg cells) play a key role in maintaining tolerance and immune homeostasis. Here, we report that a T cell-specific deletion of the transcription factor MAZR (also known as PATZ1) leads t

Externí odkaz: https://doaj.org/article/974129bdad3742e980b60d2cd2ed4c8c

Targeting the catalytic activity of HDAC1 in T cells protects against experimental autoimmune encephalomyelitis

Autor: Ci Zhu, Valentina Stolz, Natalija Simonovic, Osamah Al-Rubaye, Terezia Vcelkova, Verena Moos, Lena Hess, Astrid Hagelkruys, Moritz Madern, Wolfgang Reiter, Arabella Meixner, Christoph Bock, Markus Hartl, Ellmeier Ellmeier, Christian Seiser

Histone deacetylases are key epigenetic regulators that control T cell-mediated immunity. A T cell-specific deletion ofHdac1(HDAC1cKO) protects mice against experimental autoimmune encephalomyelitis (EAE). However, it remains elusive whether inhibiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12f63335e54e471d2d36262cf434fd60
https://doi.org/10.1101/2023.04.14.536700

24-Nor-ursodeoxycholic acid counteracts TH17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating TH17 cells

Autor: Ci Zhu, Nicole Boucheron, Ramona Rica, Valentina Stolz, Emina Halilbasic, Thierry Claudel, Osamah Al-Rubaye, Alexander Lercher, Maximilian Baumgartner, Lisa Sandner, Teresa Preglej, Marlis Alteneder, Veronika Mlitz, Claudia D. Fuchs, Daniela Hainberger, Jelena Remetic, Anna Ohradanova-Repic, Philipp Schatzlmaier, Tatjana Stojakovic, Hubert Scharnagl, Shinya Sakaguchi, Andreas Bergthaler, Hannes Stockinger, Wilfried Ellmeier, Michael Trauner

Objective24-Nor-ursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid for treating primary sclerosing cholangitis (PSC), an immune-mediated cholestatic liver disease. Since PSC strongly associates with inflammatory bowel diseases (IBD) driv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8263ba9277e30708557ec5cfc1446399
https://doi.org/10.1101/2022.02.10.479975

Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases

Autor: Anton Kamnev, Nicole Boucheron, Christian Seiser, Ci Zhu, Patricia Hamminger, Elisa Kaba, Johannes B. Huppa, Wilfried Ellmeier, Loïc Dupré, Christoph Bock, Ramona Rica, Teresa Preglej, Michael Trauner, Ruth Lyck, Marlis Alteneder, René Platzer, Britta Engelhardt, Darina Waltenberger, Valentina Stolz, Luca Marchetti, Jan Bauer, Lisa Sandner

Publikováno v: Journal of Autoimmunity
Journal of Autoimmunity, 2021, 119, pp.102610. ⟨10.1016/j.jaut.2021.102610⟩
Hamminger, Patricia; Marchetti, Luca; Preglej, Teresa; Platzer, René; Zhu, Ci; Kamnev, Anton; Rica, Ramona; Stolz, Valentina; Sandner, Lisa; Alteneder, Marlis; Kaba, Elisa; Waltenberger, Darina; Huppa, Johannes B; Trauner, Michael; Bock, Christoph; Lyck, Ruth; Bauer, Jan; Dupré, Loïc; Seiser, Christian; Boucheron, Nicole; ... (2021). Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. Journal of autoimmunity, 119, p. 102610. Elsevier 10.1016/j.jaut.2021.102610

International audience; CD4+ T cell trafficking is a fundamental property of adaptive immunity. In this study, we uncover a novel role for histone deacetylase 1 (HDAC1) in controlling effector CD4+ T cell migration, thereby providing mechanistic insi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bb29835221f575fe8eeffdd74ca545