The Q336H MAPT Mutation Linked to Pick’s Disease Leads to Increased Binding of Tau to the Microtubule Network via Altered Conformational and Phosphorylation Effects

Autor: Giacomo Siano, Mariachiara Micaelli, Arianna Scarlatti, Valentina Quercioli, Cristina Di Primio, Antonino Cattaneo

Publikováno v: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Tauopathies are neurodegenerative disorders characterized by Tau aggregation. Genetic studies on familial cases allowed for the discovery of mutations in the MAPT gene that increase Tau propensity to detach from microtubules and to form insoluble cyt

Externí odkaz: https://doaj.org/article/1f036d13b64049ceb2c4bf669ee3669f

Alpha-Synuclein FRET Biosensors Reveal Early Alpha-Synuclein Aggregation in the Endoplasmic Reticulum

Autor: Fabiana Miraglia, Verdiana Valvano, Lucia Rota, Cristina Di Primio, Valentina Quercioli, Laura Betti, Gino Giannaccini, Antonino Cattaneo, Emanuela Colla

Publikováno v: Life, Vol 10, Iss 8, p 147 (2020)

Endoplasmic reticulum (ER) dysfunction is important for alpha-synuclein (αS) acquired toxicity. When targeted to the ER in SH-SY5Y cells, transient or stable expression of αS resulted in the formation of compact αS-positive structures in a small s

Externí odkaz: https://doaj.org/article/f3f3e545d3294113ba85298d113a2269

SUGT1 controls susceptibility to HIV-1 infection by stabilizing microtubule plus-ends

Autor: Guido Kroemer, Audrey Paoletti, Awatef Allouch, Gabrielle Lê-Bury, Marie-Lise Gougeon, Cristina Di Primio, Annie David, Mauro Piacentini, Gianfranco Pancino, Guillaume Montagnac, Valentina Quercioli, Jean-Luc Perfettini, Asier Sáez-Cirión, Anna Cereseto, Roberta Nardacci, Frédéric Subra, David M. Ojcius, Florence Niedergang, Héla Saïdi

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, 2020, Online ahead of print, pp.18-22. ⟨10.1038/s41418-020-0573-5⟩
Cell death and differentiation, vol 27, iss 12
Cell Death and Differentiation, Nature Publishing Group, 2020, Online ahead of print, pp.18-22. ⟨10.1038/s41418-020-0573-5⟩
Cell Death Differ

International audience; Understanding the viral-host cell interface during HIV-1 infection is a prerequisite for the development of innovative antiviral therapies. Here we show that the suppressor of G2 allele of skp1 (SUGT1) is a permissive factor f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be4bb9bbfa61a4cd638434a398feec9a
https://doi.org/10.1038/s41418-020-0573-5

Tau Modulates VGluT1 Expression

Autor: Marco Mainardi, Valentina Quercioli, Martina Varisco, Maria Claudia Caiazza, Giacomo Siano, Antonino Cattaneo, Cristina Di Primio, Chiara Ippolito

Publikováno v: Journal of molecular biology. 431(4)

Tau displacement from microtubules is the first step in the onset of tauopathies and is followed by toxic protein aggregation. However, other non-canonical functions of Tau might have a role in these pathologies. Here, we demonstrate that a small amo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1594c1d4d6f89fc45adbad967b4a3101
https://pubmed.ncbi.nlm.nih.gov/30664870

Nuclear Tau modulates VGluT1 expression: a new function for Tau

Autor: Chiara Ippolito, Marco Mainardi, Cristina Di Primio, Maria Claudia Caiazza, Martina Varisco, Valentina Quercioli, Antonino Cattaneo, Giacomo Siano

SummaryTau displacement from microtubules is the first step in the onset of tauopathies, and is followed by toxic protein aggregation. However, other non-canonical functions of Tau might have a role in these pathologies. Here, we demonstrate that a s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b53b70536358867304ec003aba6dcdd6
https://doi.org/10.1101/394312