Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Valentina Porcari"'
Autor:
Cristiana Castaldo, Silvia Ciambellotti, Raquel de Pablo-Latorre, Daniela Lalli, Valentina Porcari, Paola Turano
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71657 (2013)
Recombinant human Glutaminyl Cyclase expressed in E. coli is produced as inclusion bodies. Lack of glycosylation is the main origin of its accumulation in insoluble aggregates. Mutation of single isolated hydrophobic amino acids into negative amino a
Externí odkaz:
https://doaj.org/article/08b72f1f483a4db7a361c7e1338f8eac
Autor:
Giuseppe Pollio, Silvia Agostini, Valentina Casieri, Fabio A. Recchia, Giovanni Donato Aquaro, Marco Matteucci, Marco Rossi, Valentina Porcari, Massimiliano Travagli, Daniela Diamanti, Vincenzo Lionetti, Khatia Gabisonia
Publikováno v:
Cardiovascular Research. 112:645-655
Aims Combined magnetic resonance imaging (MRI) of molecular and morpho-functional changes might prove highly valuable for the elucidation of pathological processes involved in the development of cardiac diseases. Our aim was to test a novel MRI repor
Autor:
Valentina Porcari, Maurizio Varrone, Silvia Valensin, Elisa Mori, M. Otrocka, Wolfgang Fecke, Daniela Diamanti, Tiziana Benicchi, Cristiana Castaldo, P. Ferruzzi, E. Pilli
Publikováno v:
SLAS Discovery. 19:859-869
The CXC chemokine receptor 4 (CXCR4) is a widely expressed G protein-coupled receptor implicated in several diseases. In cancer, an increased number of surface CXCR4 receptors, in parallel with aberrant signaling, have been reported to influence seve
Autor:
Cesare Federico, Andrea Caricasole, Letizia Magnoni, Wolfgang Fecke, Valentina Porcari, Freddy Heitz, Giulia Lazzeroni, Salvatore La Rosa, Luisa Massai, Tiziana Benicchi, Lara Rossini, Daniela Diamanti
Publikováno v:
SLAS Discovery. 18:984-996
Huntington's Disease is a rare neurodegenerative disease caused by an abnormal expansion of CAG repeats encoding polyglutamine in the first exon of the huntingtin gene. N-terminal fragments containing polyglutamine (polyQ) sequences aggregate and can
Autor:
Silvia Valensin, Enrica Diodato, Elena Pilli, Carla Scali, Luisa Massai, Roberta Magrini, Riccardo Roggeri, Antonella De Rosa, Fabio A. Recchia, Nicola P. Caradonna, Sara Chellini, Giuseppe Pollio, Patrizia Tunici, Valentina Porcari, Gianluca Sardone, Pasquale Fiengo, Letizia Magnoni, Silvia Coniglio, Vincenzo Lionetti, Daniela Diamanti, Martina Monti, Marco Rossi
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 86
Preclinical imaging modalities represent an essential tool to develop a modern and translational biomedical research. To date, Optical Imaging (OI) and Magnetic Resonance Imaging (MRI) are used principally in separate studies for molecular imaging st
Autor:
Sara Chellini, Antonio Lorenzetto, Laura Maccari, Barbara Cellini, Elisa Oppici, Carla Borri Voltattorni, Valentina Porcari, Mirco Dindo, Riccardo Montioli
Publikováno v:
ACS chemical biology. 10(10)
The rare disease Primary Hyperoxaluria Type I (PH1) results from the deficit of liver peroxisomal alanine:glyoxylate aminotransferase (AGT), as a consequence of inherited mutations on the AGXT gene frequently leading to protein misfolding. Pharmacolo
Autor:
Nicola P. Caradonna, Giulia Lazzeroni, David C. Rubinsztein, Fiona M. Menzies, Alessia Tarditi, Venkata P. Satagopam, Valentina Porcari, Angeleen Fleming, Reinhard Schneider, Freddy Heitz, Chiara Caramelli, Birte Sönnichsen, Maria Jimenez-Sanchez, Carla Scali, Sara Imarisio, Michael Hannus, Giuseppe Pollio, Wun Lam, Daniela Diamanti, Catherine K. Xu, Eduardo Gonzalez-Couto, Arianna Nencini, Gian Luca Sardone, Andrea Caricasole, Cahir J. O'Kane, Matteo Andreini, Luisa Massai, Guido Marconi, Teresa Ed Dami
Publikováno v:
Nature chemical biology
Nature chemical biology, 11(5), 347–354. (2015).
Nature chemical biology, 11(5), 347–354. (2015).
Huntington’s disease (HD) is a currently incurable neurodegenerative condition caused by an abnormally expanded polyglutamine tract in huntingtin (HTT). We identified novel modifiers of mutant HTT toxicity by performing a large-scale “druggable g
Autor:
Elisa Mori, Chiara Caramelli, Hanna Axelsson, Laura Maccari, Paola Fanti, Eva Genesio, Johan Schultz, Sara Iozzi, Simonetta Bernocco, Natalia Markova, Tiziana Benicchi, Andreas Svahn, Wolfgang Fecke, Valentina Porcari, Iolanda Micco, Federico Cappelli
Publikováno v:
Journal of biomolecular screening. 17(7)
The TWEAK-Fn14 pathway is upregulated in models of inflammation, autoimmune diseases, and cancer. Both TWEAK and Fn14 show increased expression also in the CNS in response to different stimuli, particularly astrocytes, microglia, and neurons, leading
Design, synthesis and docking studies of Hydroxyethylamine and Hydroxyethylsulfide BACE-1 inhibitors
Autor:
Luca Rizzi, Valentina Porcari, Francesca Sagui, Nadia Vaiana, Sergio Romeo, Eva Genesio, Elena Pilli
Publikováno v:
Protein and peptide letters. 16(1)
Both stereoisomer of hydroxyethylamine (HEA) and hydroxyethylsulfide (HES) transition-state isostere inhibitors of BACE-1 were synthesized. The syn-HEA epimer resulted always more active than the anti stereoisomer independently from the P(1) and the
Publikováno v:
The Journal of pharmacy and pharmacology. 58(4)
A series of arylpropargylamines, variously substituted in the hydrogen in p-position and in the propargyl moiety, were studied as potential peroxynitrite scavengers. The scavenging activity of these compounds was evaluated through peroxynitrite (ONOO