Sequential treatment with a TNFR2 agonist and a TNFR1 antagonist improves outcomes in a humanized mouse model for MS

Autor: Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel

Publikováno v: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-13 (2023)

Abstract TNF signaling is an essential regulator of cellular homeostasis. Through its two receptors TNFR1 and TNFR2, soluble versus membrane-bound TNF enable cell death or survival in a variety of cell types. TNF-TNFRs signaling orchestrates importan

Externí odkaz: https://doaj.org/article/5841bf7052c54683ab34c56469546a89

Intrathymic dendritic cell-biased precursors promote human T cell lineage specification through IRF8-driven transmembrane TNF

Autor: Kai Ling Liang, Juliette Roels, Marieke Lavaert, Tom Putteman, Lena Boehme, Laurentijn Tilleman, Imke Velghe, Valentina Pegoretti, Inge Van de Walle, Stephanie Sontag, Jolien Vandewalle, Bart Vandekerckhove, Georges Leclercq, Pieter Van Vlierberghe, Claude Libert, Filip Van Nieuwerburgh, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Gina Doody, Martin Zenke, Tom Taghon

Publikováno v: Nature Immunology. 24:474-486

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fe8dd9eba6e89dff5ac443d4375330b
https://doi.org/10.1038/s41590-022-01417-6

SK channel activation is neuroprotective in conditions of enhanced ER-mitochondrial coupling

Autor: Carsten Culmsee, Valentina Pegoretti, Nadia Bendridi, Carmen IJsebaart, Amalia M. Dolga, Martina Schmidt, Inge Krabbendam, Birgit Honrath, Jennifer Rieusset

Publikováno v: Cell death & disease
Cell death & disease, 2018, 9, pp.11
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2018, 9 (6), pp.11. ⟨10.1038/s41419-018-0590-1⟩
Cell Death and Disease (9), . (2018)
Cell death & disease, 2018, 9, pp.11. ⟨10.1038/s41419-018-0590-1⟩
Cell death & disease, 9(6):593. Nature Publishing Group
Cell Death and Disease, Vol 9, Iss 6, Pp 1-11 (2018)
Cell Death & Disease

Alterations in the strength and interface area of contact sites between the endoplasmic reticulum (ER) and mitochondria contribute to calcium (Ca2+) dysregulation and neuronal cell death, and have been implicated in the pathology of several neurodege

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8954685030cbc1cc2b79efca5bd1d185
https://hal.archives-ouvertes.fr/hal-02003881

SK channels at the ER-mitochondrial interface preserve neuronal survival in conditions of enhanced calcium transfer and impaired mitochondrial bioenergetics

Autor: Birgit Honrath, Inge Krabbendam, Carmen IJsebaart, Valentina Pegoretti, Martina Schmidt, Carsten Culmsee, Amalia Dolga

Publikováno v: Neurochemical Conference 2017
University of Groningen

The crosstalk between the endoplasmic reticulum (ER) and mitochondria facilitates calcium transfer between these organelles, thereby maintaining the driving force for calcium into the mitochondrial matrix to facilitate mitochondrial respiration and A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::733c839bd5d48f8d1b6751e1d2b711dd
https://research.rug.nl/en/publications/2844c5dc-be08-48b1-9d57-ed1bb3face96

The role of SK channels at the ER – mitochondria interface

Autor: Inge Krabbendam, Birgit Honrath, Valentina Pegoretti, Martina Schmidt, Amalia Dolga

Publikováno v: University of Groningen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4ef11adaa817b548ea13b2d59cd8079a
https://research.rug.nl/en/publications/c8f084ea-6ed5-49b4-b281-195cc4670f52