Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Valentina Onnis"'
Publikováno v:
Frontiers in Chemistry, Vol 12 (2024)
Externí odkaz:
https://doaj.org/article/9f892f09951c481bbf42b629bcadeb3e
Autor:
Valeria Manca, Annalisa Chianese, Vanessa Palmas, Federica Etzi, Carla Zannella, Davide Moi, Francesco Secci, Gabriele Serreli, Giorgia Sarais, Maria Vittoria Morone, Massimiliano Galdiero, Valentina Onnis, Aldo Manzin, Giuseppina Sanna
Publikováno v:
Viruses, Vol 16, Iss 5, p 665 (2024)
Severe acute respiratory syndrome-related Coronavirus 2 (SARS-CoV-2) has infected more than 762 million people to date and has caused approximately 7 million deaths all around the world, involving more than 187 countries. Although currently available
Externí odkaz:
https://doaj.org/article/9c48b7147be548c19d2b9ff9c0136619
Autor:
Valentina Onnis
Publikováno v:
Pharmaceuticals, Vol 16, Iss 10, p 1437 (2023)
Cancer is a disease that can affect any organ and spread to other nearby or distant organs [...]
Externí odkaz:
https://doaj.org/article/b099a2a1b3dc43d2a204702b10a9cdf2
Autor:
Giulia Galimberti, Giada Amodeo, Giulia Magni, Benedetta Riboldi, Gianfranco Balboni, Valentina Onnis, Stefania Ceruti, Paola Sacerdote, Silvia Franchi
Publikováno v:
Cells, Vol 12, Iss 18, p 2255 (2023)
Osteoarthritis (OA) is the most prevalent joint disease associated with chronic pain. OA pain is often accompanied by mood disorders. We addressed the role of the Prokineticin (PK) system in pain and mood alterations in a mice OA model induced with m
Externí odkaz:
https://doaj.org/article/0d6dc3378a024dd2a8e6574e8620f693
Autor:
Alessandro Deplano, Jessica Karlsson, Federica Moraca, Mona Svensson, Claudia Cristiano, Carmine Marco Morgillo, Christopher J. Fowler, Roberto Russo, Bruno Catalanotti, Valentina Onnis
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 940-953 (2021)
Compounds combining dual inhibitory action against FAAH and cyclooxygenase (COX) may be potentially useful analgesics. Here, we describe a novel flurbiprofen analogue, N-(3-bromopyridin-2-yl)-2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanamide (Flu-AM4). Th
Externí odkaz:
https://doaj.org/article/0b5582ac7f564cf380fe77d5fa6cd305
Autor:
Carmine Marco Morgillo, Antonio Lupia, Alessandro Deplano, Luciano Pirone, Bianca Fiorillo, Emilia Pedone, F. Javier Luque, Valentina Onnis, Federica Moraca, Bruno Catalanotti
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15502 (2022)
Fatty acid amide hydrolase (FAAH) plays a key role in the control of cannabinoid signaling and it represents a promising therapeutic strategy for the treatment of a wide range of diseases, including neuropathic pain and chronic inflammation. Starting
Externí odkaz:
https://doaj.org/article/9e1cf818417c4a779ef21a9dfd5d4fee
Autor:
Tinuccia Dettori, Giuseppina Sanna, Andrea Cocco, Gabriele Serreli, Monica Deiana, Vanessa Palmas, Valentina Onnis, Luca Pilia, Nicola Melis, Davide Moi, Paola Caria, Francesco Secci
Publikováno v:
Molecules, Vol 27, Iss 24, p 8897 (2022)
A series of 6- and 6,8-halocoumarin derivatives have been investigated as potential antiproliferative compounds against a panel of tumor and normal cell lines. Cytotoxic effects were determined by the MTT method. To investigate the potential molecula
Externí odkaz:
https://doaj.org/article/409d3269ddb243fb80c76aed7cc7e4d6
Autor:
Davide Moi, Serena Vittorio, Andrea Angeli, Gianfranco Balboni, Claudiu T. Supuran, Valentina Onnis
Publikováno v:
Molecules, Vol 28, Iss 1, p 91 (2022)
A small series of hydrazonobenzenesulfonamides was designed, synthesized and studied for their human carbonic anhydrase (hCA) inhibitory activity. The synthesized compounds were evaluated against hCA I, II, IX and XII isoforms using acetazolamide (AA
Externí odkaz:
https://doaj.org/article/3b80dd7051c24155b0d4ca4e6d1483f9
Autor:
Alessandro Deplano, Jessica Karlsson, Mona Svensson, Federica Moraca, Bruno Catalanotti, Christopher J. Fowler, Valentina Onnis
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 815-823 (2020)
Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and indomethacin in experimental animals, suggesting that a dual-action FAAH-cyclooxygenase (COX)
Externí odkaz:
https://doaj.org/article/0f50faf3cf0e43df86dcdb218f2f2fdd
Autor:
Davide Moi, Alessandro Deplano, Andrea Angeli, Gianfranco Balboni, Claudiu T. Supuran, Valentina Onnis
Publikováno v:
Molecules, Vol 27, Iss 17, p 5370 (2022)
Here we report a small library of hydrazinocarbonyl-ureido and thioureido benzenesulfonamide derivatives, designed and synthesized as potent and selective human carbonic anhydrase inhibitors (hCAIs). The synthesized compounds were evaluated against i
Externí odkaz:
https://doaj.org/article/f319261a061847679e8983cf7329755b