Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Valentina Manfé"'
Autor:
Valentina Manfè, Edyta Biskup, Ayalah Willumsgaard, Anne Guldhammer Skov, Dario Palmieri, Pierluigi Gasparini, Alessandro Laganá, Anders Woetmann, Niels Ødum, Carlo Maria Croce, Robert Gniadecki
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59390 (2013)
Successful/effective cancer therapy in low grade lymphoma is often hampered by cell resistance to anti-neoplastic agents. The crucial mechanisms responsible for this phenomenon are poorly understood. Overcoming resistance of tumor cells to anticancer
Externí odkaz:
https://doaj.org/article/ea587a01dd224e5f866a2e5d59ee46c7
Publikováno v:
Dermatology Reports, Vol 2, Iss 1, Pp e8-e8 (2010)
We have investigated cell growth dynamics and cyclins B1 and E expression in cell lines derived from mycosis fungoides (MyLa), Sézary syndrome (SeAx), and CD30+ lympho-proliferative diseases (Mac1, Mac2a, JK). Mac1 and Mac2a had the highest growth r
Externí odkaz:
https://doaj.org/article/b470996ec1e141538440bad5cdc3a6af
Autor:
Sanna Hellberg, Osman Ahmed, Yuyang Zhang, Giada Di Nunzio, Hanna M Björck, Roy Francis, Linn Fagerberg, Anton Gisterå, Xueming Zhang, Jari Metso, Valentina Manfé, Yosdel Soto, Anders Franco-Cereceda, Per Eriksson, Matti Jauhiainen, Peder S. Olofsson, Stephen G. Malin
Apolipoprotein-B (APOB) containing lipoproteins are causative for atherosclerotic cardiovascular disease. Whether the vasculature is the initial responding site or if atherogenic-dyslipidemia effects other organs simultaneously is unknown. We set out
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2698f270010d9aa1764311ad0c4afc65
https://doi.org/10.1101/2022.10.13.512086
https://doi.org/10.1101/2022.10.13.512086
Publikováno v:
Leukemia & Lymphoma. 56:739-747
The tumor suppressor p53 is often mutated in human cancers. Restoring its antitumor activity has been shown to be a promising therapeutic approach for cancer treatment. Here we analyzed the activity and mechanism of a p53 reactivator, ellipticine, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aadc850134b17b01bc9a13a1e99b0800
https://doi.org/10.3109/10428194.2014.929673
https://doi.org/10.3109/10428194.2014.929673
Publikováno v:
British Journal of Dermatology. 168:504-512
Summary Background We have previously discovered that Notch1 is expressed on malignant T cells in cutaneous T-cell lymphoma (CTCL), and is required for survival of CTCL cell lines. Notch can be inhibited by γ-secretase inhibitors (GSIs), which diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0eecf95c00327f185e8dfb45a3afcb8
https://doi.org/10.1111/bjd.12071
https://doi.org/10.1111/bjd.12071
Autor:
Robert Gniadecki, Valentina Manfé, Lasse Folkersen, Ning Xu, Tianling Wei, Edyta Biskup, Omid Niazi
Publikováno v:
Wei, T, Folkersen, L, Biskup, E, Xu, N, Manfe, V, Niazi, O & Gniadecki, R 2017, ' Ubiquitin-specific peptidase 2 as a potential link between microRNA-125b and psoriasis ', British Journal of Dermatology, vol. 176, no. 3, pp. 723-731 . https://doi.org/10.1111/bjd.14916
BACKGROUND: The extensive involvement of microRNA (miRNA) in the pathophysiology of psoriasis is well documented. However, in order for this information to be useful in therapeutic manipulation of miRNA levels, it is essential that detailed functiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f900ea13e61238e83e3ce4a5412d72
https://pubmed.ncbi.nlm.nih.gov/27479112
https://pubmed.ncbi.nlm.nih.gov/27479112
Autor:
Valentina Manfé, Robert Gniadecki, Walter Joseph Liszewski, Edyta Biskup, Lena Specht, Maria R. Kamstrup, Johan Wirén, Cecilia Savorani
Publikováno v:
Leukemialymphoma. 58(1)
The Notch pathway is important for survival of cutaneous T-cell lymphoma (CTCL) cells. We investigated the effect of chemotherapy (doxorubicin, etoposide, and gemcitabine) and radiation modalities on Notch signaling in CTCL cell lines. Chemotherapy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4cc888ebea6fcd35d6fca67243390b5
https://pubmed.ncbi.nlm.nih.gov/27181628
https://pubmed.ncbi.nlm.nih.gov/27181628
Autor:
Robert Gniadecki, Edyta Biskup, Thorbjørn Krejsgaard, Maria R. Kamstrup, Hans Christian Wulf, Niels Morling, Peter Johansen, Valentina Manfé
Publikováno v:
The Journal of investigative dermatology. 132(5)
P53 is rarely mutated in cutaneous T-cell lymphoma (CTCL) and is therefore a promising target for innovative therapeutic approaches. Nutlin-3a is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe6d6b3b8fe7a811afb809871e41cdb
https://pubmed.ncbi.nlm.nih.gov/22377766
https://pubmed.ncbi.nlm.nih.gov/22377766
Autor:
Maria R. Kamstrup, Britt Lauenborg, Robert Gniadecki, Catharina M. Lerche, Anne Guldhammer Skov, Anne Rosbjerg, Edyta Biskup, Niels Ødum, Valentina Manfé
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29541 (2012)
PLoS ONE
PLoS ONE
Advanced cutaneous T-cell lymphoma (CTCL) is resistant to chemotherapy and presents a major area of medical need. In view of the known role of microRNAs (miRNAs) in the regulation of cellular signalling, we aimed to identify the functionally importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe3d9bb0607d54038f0dd37c3f8cefc0
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22235305/pdf/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22235305/pdf/?tool=EBI
Autor:
Anne Marie Ahlburg Dirksen, Finn Cilius Nielsen, Robert Gniadecki, Line Marie Broksø Holst, Krzysztof T. Drzewiecki, Edyta Biskup, Martin Glud, Nina Hastrup, Valentina Manfé
Publikováno v:
Melanoma research. 21(3)
MicroRNAs (miRNAs) are small noncoding RNA molecules involved in gene regulation. Aberrant expression of miRNA has been associated with the development or progression of several diseases, including cancer. In a previous study, we found that the expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb36b00c6946cf10848b5deb653cffdd
https://pubmed.ncbi.nlm.nih.gov/21460750
https://pubmed.ncbi.nlm.nih.gov/21460750