Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Valentina K Todorova"'
Autor:
Ping-Ching Hsu, Susan A Kadlubar, Eric R Siegel, Lora J Rogers, Valentina K Todorova, L Joseph Su, Issam Makhoul
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0230248 (2020)
TRIAL REGISTRATION:ClinicalTrials.gov Identifier: NCT00203502.
Externí odkaz:
https://doaj.org/article/fe572f7e698942a9ae40fff8dfc16317
Autor:
Issam Makhoul, Valentina K Todorova, Eric R Siegel, Stephen W Erickson, Ishwori Dhakal, Vinay R Raj, Jeannette Y Lee, Mohammed S Orloff, Robert J Griffin, Ronda S Henry-Tillman, Suzanne Klimberg, Laura F Hutchins, Susan A Kadlubar
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0168550 (2017)
We previously reported improved pathologic complete response (pCR) in a prospective phase II study using neoadjuvant bevacizumab in combination with chemotherapy compared to chemotherapy alone in breast cancer patients (41% vs. 25%, p = 0.0291). In t
Externí odkaz:
https://doaj.org/article/1c2045b9e955450ebf6d379461582e99
Autor:
Valentina K Todorova, Issam Makhoul, Eric R Siegel, Jeanne Wei, Annjanette Stone, Weleetka Carter, Marjorie L Beggs, Aaron Owen, V Suzanne Klimberg
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160224 (2016)
Cardiotoxicity of doxorubicin (DOX) remains an important health concern. DOX cardiotoxicity is cumulative-dose-dependent and begins with the first dose of chemotherapy. No biomarker for presymptomatic detection of DOX cardiotoxicity has been validate
Externí odkaz:
https://doaj.org/article/c687a01aadb54891aa6a5e47fca0e4c1
Autor:
Valentina K. Todorova, Gohar Azhar, Annjanette Stone, Sindhu J. Malapati, Yingni Che, Wei Zhang, Issam Makhoul, Jeanne Y. Wei
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9735 (2024)
Doxorubicin (DOX), a commonly used anticancer agent, causes cardiotoxicity that begins with the first dose and may progress to heart failure years after treatment. An inflammatory response associated with neutrophil recruitment has been recognized as
Externí odkaz:
https://doaj.org/article/d525abc9150e4727ade96df1e9d2435b
Autor:
Valentina K Todorova, Marjorie L Beggs, Robert R Delongchamp, Ishwori Dhakal, Issam Makhoul, Jeanne Y Wei, V Suzanne Klimberg
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48398 (2012)
Doxorubicin (DOX), a widely used anticancer agent, can cause an unpredictable cardiac toxicity which remains a major limitation in cancer chemotherapy. There is a need for noninvasive, sensitive and specific biomarkers which will allow identifying pa
Externí odkaz:
https://doaj.org/article/efe90c5f5e10404d8bf056c130a1d891
Autor:
Valentina K. Todorova, Stephanie D. Byrum, Allen J. Gies, Cade Haynie, Hunter Smith, Nathan S. Reyna, Issam Makhoul
Publikováno v:
Current Oncology; Volume 29; Issue 2; Pages: 613-630
Background: Neoadjuvant chemotherapy (NACT) is an increasingly used approach for treatment of breast cancer. The pathological complete response (pCR) is considered a good predictor of disease-specific survival. This study investigated whether circula
Autor:
Tetiana Odynets, Petro Rybalko, Yuriy Briskin, Pavlo Vindiuk, Borys Tymofiyovych Dolinsky, Anzhelika Yefremova, Valentina K. Todorova
Publikováno v:
Physiotherapy Quarterly, Vol 29, Iss 1, Pp 56-60 (2021)
Autor:
V. Suzanne Klimberg, Asangi R. Kumarapeli, Issam Makhoul, Valentina K. Todorova, Eric R. Siegel, Yihong Kaufmann, Aaron Owen, Jeanne Y. Wei
Publikováno v:
Translational Oncology
Translational Oncology, Vol 13, Iss 2, Pp 471-480 (2020)
Translational Oncology, Vol 13, Iss 2, Pp 471-480 (2020)
Dysregulation of calcium homeostasis is a major mechanism of doxorubicin (DOX)-induced cardiotoxicity. Treatment with DOX causes activation of sarcoplasmic reticulum (SR) ryanodine receptor (RYR) and rapid release of Ca2+ in the cytoplasm resulting i
Publikováno v:
Physiotherapy Quarterly, Vol 28, Iss 1, Pp 6-10 (2020)
Publikováno v:
Am J Cancer Res
Doxorubicin (DOX) is a highly effective chemotherapy agent that often causes cardiotoxicity. Despite a number of extensive studies, the risk for DOX cardiotoxicity remains unpredictable. The majority of the studies on DOX-induced cardiotoxicity have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f7ad1471986f6d52a5ad6bf29998d9d1
https://europepmc.org/articles/PMC8493405/
https://europepmc.org/articles/PMC8493405/