Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61

Autor: Andrea Calcaterra, Valentina Iovine, Bruno Botta, Deborah Quaglio, Ilaria D’Acquarica, Alessia Ciogli, Antonia Iazzetti, Romina Alfonsi, Ludovica Lospinoso Severini, Paola Infante, Lucia Di Marcotullio, Mattia Mori, Francesca Ghirga

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 349-358 (2018)

This work aims at elucidating the mechanism and kinetics of hydrolysis of GANT61, the first and most-widely used inhibitor of the Hedgehog (Hh) signalling pathway that targets Glioma-associated oncogene homologue (Gli) proteins, and at confirming the

Externí odkaz: https://doaj.org/article/01013017b3ab40e0b224300d4e77ab74

Natural Product Kuwanon-L Inhibits HIV-1 Replication through Multiple Target Binding

Autor: Riccardo Martini, Cristina Tintori, Angela Corona, Enzo Tramontano, Andrea Calcaterra, Filippo Canducci, Roberto Ferrarese, Francesca Esposito, Valentina Iovine, Elisa Rita Ceresola, Alessandro Barbieri, Laura Visconti, Maurizio Botta

In recent years many advances have been made in the fight against HIV-1 infection. However, the lack of a vaccine, together with the increasing resistance to the highly active anti-retroviral therapy (HAART), make HIV-1 infection still a serious glob

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7fd5eb915050cd9c2cf3b660259eac
http://hdl.handle.net/11383/2061322

Competitive carbothiolation and sonogashira cross-coupling in the reaction of trimethylsilylacetylene with arylthioacetates

Autor: Valentina Iovine, [a] Federico Cruciani, [a] Flavio Picini, [a] Marta Varrone, [b] Enrico Rossi, [b] Mauro Bassetti, [b], Andrea D'Annibale*[a]

Publikováno v: ChemistrySelect 1 (2016): 5201–5205. doi:10.1002/slct.201601373
info:cnr-pdr/source/autori:Valentina Iovine,[a] Federico Cruciani,[a] Flavio Picini,[a] Marta Varrone,[b] Enrico Rossi,[b] Mauro Bassetti,*[b] and Andrea D'Annibale*[a]/titolo:Competitive carbothiolation and sonogashira cross-coupling in the reaction of trimethylsilylacetylene with arylthioacetates/doi:10.1002%2Fslct.201601373/rivista:ChemistrySelect/anno:2016/pagina_da:5201/pagina_a:5205/intervallo_pagine:5201–5205/volume:1

p-Bromo- or p-iodophenylthioacetate can react with trimethylsilylacetylene by simultaneous Sonogashira coupling at the halide function and addition of acetyl and arylthio moieties to the triple bond. Reaction of arylthioacetates with p-OMe, -Me, Ph a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522a36226057426581781b7d322ffe76
http://hdl.handle.net/11573/930138

Synthesis of a Double-Spanned Resorc[4]arene via Ring-Closing Metathesis and Calculation of Aggregation Propensity

Autor: Francesca Ghirga, Luisa Mannina, Anatoly P. Sobolev, Deborah Quaglio, Valentina Iovine, Franco Ugozzoli, Ilaria D'Acquarica, Bruno Botta, Marco Pierini

Publikováno v: Journal of organic chemistry 79 (2014): 11051–11060. doi:10.1021/jo502056v
info:cnr-pdr/source/autori:Ghirga, Francesca; Quaglio, Deborah; Iovine, Valentina; Botta, Bruno; Pierini, Marco; Mannina, Luisa; Sobolev, Anatoly P.; Ugozzoli, Franco; D'Acquarica, Ilaria/titolo:Synthesis of a double-spanned resorc[4]arene via ring-closing metathesis and calculation of aggregation propensity/doi:10.1021%2Fjo502056v/rivista:Journal of organic chemistry/anno:2014/pagina_da:11051/pagina_a:11060/intervallo_pagine:11051–11060/volume:79

Ring-closing metathesis (RCM) catalyzed by a second-generation Grubbs catalyst has been used to synthesize resorc[4]arenes 2b - 5b starting from undecenyl resorc[4]arene 1b fi xed in the cone conformation. X-ray diffraction analysis of the major meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc9682fbbd7b602775bb0cf6b21feb1
http://hdl.handle.net/11573/615616