Zobrazeno 1 - 10 of 79 pro vyhledávání: '"Valentina Iannuccelli"'
1
Akademický článek
Design, Characterization, and In Vitro Assays on Muscle Cells of Endocannabinoid-like Molecule Loaded Lipid Nanoparticles for a Therapeutic Anti-Inflammatory Approach to Sarcopenia
Autor: Eleonora Maretti, Susanna Molinari, Renata Battini, Cecilia Rustichelli, Eleonora Truzzi, Valentina Iannuccelli, Eliana Leo
Publikováno v: Pharmaceutics, Vol 14, Iss 3, p 648 (2022)
Inflammatory processes play a key role in the pathogenesis of sarcopenia owing to their effects on the balance between muscle protein breakdown and synthesis. Palmitoylethanolamide (PEA), an endocannabinoid-like molecule, has been well documented for
Externí odkaz: https://doaj.org/article/6ddec7a9c1064901a15c410bb4c8c124
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2
Akademický článek
In Vivo Biodistribution of Respirable Solid Lipid Nanoparticles Surface-Decorated with a Mannose-Based Surfactant: A Promising Tool for Pulmonary Tuberculosis Treatment?
Autor: Eleonora Truzzi, Thais Leite Nascimento, Valentina Iannuccelli, Luca Costantino, Eliana Martins Lima, Eliana Leo, Cristina Siligardi, Magdalena Lassinantti Gualtieri, Eleonora Maretti
Publikováno v: Nanomaterials, Vol 10, Iss 3, p 568 (2020)
The active targeting to alveolar macrophages (AM) is an attractive strategy to improve the therapeutic efficacy of ‘old’ drugs currently used in clinical practice for the treatment of pulmonary tuberculosis. Previous studies highlighted the abili
Externí odkaz: https://doaj.org/article/444bfbff439f42f4a54e77b93f1c34f6
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3
Akademický článek
The Impact of Lipid Corona on Rifampicin Intramacrophagic Transport Using Inhaled Solid Lipid Nanoparticles Surface-Decorated with a Mannosylated Surfactant
Autor: Eleonora Maretti, Cecilia Rustichelli, Magdalena Lassinantti Gualtieri, Luca Costantino, Cristina Siligardi, Paola Miselli, Francesca Buttini, Monica Montecchi, Eliana Leo, Eleonora Truzzi, Valentina Iannuccelli
Publikováno v: Pharmaceutics, Vol 11, Iss 10, p 508 (2019)
The mimicking of physiological conditions is crucial for the success of accurate in vitro studies. For inhaled nanoparticles, which are designed for being deposited on alveolar epithelium and taken up by macrophages, it is relevant to investigate the
Externí odkaz: https://doaj.org/article/44eb2f4eaedd4ec7a1c89139e3d646d1
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5
In vivo β-carotene skin permeation modulated by Nanostructured Lipid Carriers
Autor: Eleonora Maretti, Valentina Iannuccelli, Cristina Siligardi, Eleonora Truzzi, Eliana Leo, Cecilia Rustichelli
Nanostructured Lipid Carriers (NLC) were investigated with the purpose of promoting skin permeation of the highly lipophilic β-carotene (BC) across the stratum corneum (SC) barrier so that it may perform its antioxidant properties in photo-aging and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25911fc3c449f4f4b33d25f0b7537ba4
https://hdl.handle.net/11380/1236785
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6
Design and physicochemical characterization of novel hybrid SLN-liposome nanocarriers for the smart co-delivery of two antitubercular drugs
Autor: Eleonora Truzzi, Angela Capocefalo, Fiorella Meneghetti, Eleonora Maretti, Matteo Mori, Valentina Iannuccelli, Fabio Domenici, Carlo Castellano, Eliana Leo
Publikováno v: Journal of drug delivery science and technology 70 (2022): 103206-1–103206-11. doi:10.1016/j.jddst.2022.103206
info:cnr-pdr/source/autori:Truzzi E.; Capocefalo A.; Meneghetti F.; Maretti E.; Mori M.; Iannuccelli V.; Domenici F.; Castellano C.; Leo E./titolo:Design and physicochemical characterization of novel hybrid SLN-liposome nanocarriers for the smart co-delivery of two antitubercular drugs/doi:10.1016%2Fj.jddst.2022.103206/rivista:Journal of drug delivery science and technology/anno:2022/pagina_da:103206-1/pagina_a:103206-11/intervallo_pagine:103206-1–103206-11/volume:70
In the present work a novel hybrid system for the delivery of two first-line antitubercular drugs, rifampicin (RIF) and isoniazid (INH), was designed. In order to control the release of the drugs and improve the efficiency of conventional carriers, l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d026dc0922fa2e2c23e3f7d00e43aa4b
https://doi.org/10.1016/j.jddst.2022.103206
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7
Chitosan/heparin polyelectrolyte complexes as ion-paring approach to encapsulate heparin in orally administrable SLN: In vitro evaluation
Autor: Cecilia Rustichelli, Eleonora Maretti, Valentina Iannuccelli, Barbara Pavan, Alessandro Dalpiaz, Eliana Leo, Monica Montanari
Enhancing oral bioavailability of hydrophilic drugs by encapsulation in lipid-based nanocarriers, including Solid Lipid Nanoparticles (SLN), has been well documented. In this work, high molecular weight heparin was “insolubilized” by an “ion-pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a871db08e0225dbf586c8f4e9fe086
https://hdl.handle.net/11380/1212318
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8
Newly synthesized surfactants for surface mannosylation of respirable SLN assemblies to target macrophages in tuberculosis therapy
Autor: Eliana Leo, Valentina Iannuccelli, Luca Costantino, Francesca Buttini, Cecilia Rustichelli, Eleonora Truzzi, Eleonora Maretti
Publikováno v: Drug Delivery and Translational Research. 9:298-310
The present study reports about new solid lipid nanoparticle assemblies (SLNas) loaded with rifampicin (RIF) surface-decorated with novel mannose derivatives, designed for anti-tuberculosis (TB) inhaled therapy by dry powder inhaler (DPI). Mannose is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1248f9c740d4c0dd009f24fdb192aae3
https://doi.org/10.1007/s13346-018-00607-w
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9
Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones?
Autor: Miriam Hanuskova, Valentina Iannuccelli, Salvatore Pacifico, Francesca Sacchetti, Eliana Grazia Leo, Domenico D'Arca, Filippo Genovese, Maria Paola Costi, Eleonora Maretti
Publikováno v: Drug Development and Industrial Pharmacy. 43:465-473
Context: LR-peptide, a novel hydrophilic peptide synthetized and characterized in previous work, is able to reduce the multi-drug resistance response in cisplatin (cDPP) resistant cancer cells by inhibiting human thymidylate synthase (hTS) overexpres
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efca8bab726c5e9b0dc501da28cd5bb5
https://doi.org/10.1080/03639045.2016.1262870
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10
Self-assembled organogelators as artificial stratum corneum models: key-role parameters for skin permeation prediction
Autor: Cecilia Rustichelli, Eleonora Truzzi, Paola Miselli, Valentina Iannuccelli, Eliana Grazia Leo, Eleonora Maretti
Self-assembled organogelators were explored as artificial stratum corneum (SC) models for the in vitro skin permeation assessment. Four SC models consisting of binary (organogels) or ternary (microemulsion-based organogels) mixtures were developed us
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::400d0b099a06bc15058ca6f6f07bc53b
https://www.ncbi.nlm.nih.gov/pubmed/30599224
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