Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Valentina I. Grishko"'
Publikováno v:
Molecular and Cellular Biochemistry. 397:195-201
Upregulation of matrix metalloproteinases (MMPs) is a hallmark of osteoarthritis progression; along with the role reactive oxygen species (ROS) may play in this process. Moreover, mitochondrial DNA damage and dysfunction are also present in osteoarth
Autor:
Jong T. Kim, Valentina I. Grishko, A. Mates, Albert W. Pearsall, R. Xo, Min Xu, Glenn L. Wilson
Publikováno v:
Osteoarthritis and Cartilage. 18(3):424-432
Summary Objective Pro-inflammatory cytokines play a pivotal role in cartilage destruction during the progression of osteoarthritis (OA). Additionally, these cytokines are capable to generate reactive oxygen and nitrogen species within chondrocytes. M
Publikováno v:
The Journal of Bone and Joint Surgery-American Volume. 92:609-618
Several mechanisms have been proposed to explain toxicity of local anesthetics to chondrocytes, including the blockade of potassium channels and mitochondrial injury. The purposes of this investigation were to study the effects of lidocaine, bupivaca
Publikováno v:
Osteoarthritis and Cartilage. 17:107-113
Summary Objectives Osteoarthritis (OA) is characterized by the failure of chondrocytes to respond to injury and perform the cartilage remodeling process. Human articular chondrocytes actively produce reactive oxygen and nitrogen species (ROS and RNS)
Autor:
Nancy P. Thornley, Glenn L. Wilson, Susan P. LeDoux, Valentina I. Grishko, Lyudmila I. Rachek
Publikováno v:
Diabetes. 55:1022-1028
Chronic exposure to elevated levels of free fatty acids (FFAs) impairs pancreatic β-cell function and contributes to the decline of insulin secretion in type 2 diabetes. Previously, we reported that FFAs caused increased nitric oxide (NO) production
Autor:
Valentina I. Grishko, Susan P. LeDoux, Lyudmila I. Rachek, Glenn L. Wilson, Sergiy I. Musiyenko
Publikováno v:
Free Radical Biology and Medicine. 38:755-762
A growing body of evidence indicates that free fatty acids (FFA) can have deleterious effects on beta-cells. It has been suggested that the beta-cell dysfunction and death observed in diabetes may involve exaggerated activation of the inducible form
Autor:
Glenn L. Wilson, Jeffrey F. Breit, Valentina I. Grishko, Clayton C. Campbell, Kathryn A. Ziel, Mark N. Gillespie
Publikováno v:
The FASEB Journal. 19:387-394
Physiological stimuli using reactive oxygen species (ROS) as second messengers caused nucleotide-specific base modifications in the hypoxic response element of the VEGF gene in lung vascular cells, with the 3' guanine of the HIF-1 DNA recognition seq
Autor:
Valentina I. Grishko, Mikhail Alexeyev, Lyudmila I. Rachek, Glenn L. Wilson, Susan P. LeDoux, Viktoriya Pastukh
Publikováno v:
Nucleic Acids Research. 32:3240-3247
Mitochondrial DNA (mtDNA) is exposed to reactive oxygen species (ROS) produced during oxidative phosphorylation. Accumulation of several kinds of oxidative lesions, including oxidized pyrimidines, in mtDNA may lead to structural genomic alterations,
Autor:
Susan P. LeDoux, Mark R. Kelley, Valentina I. Grishko, Allison W. Dobson, Glenn L. Wilson, Mark N. Gillespie
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 283:L205-L210
In rat cultured pulmonary arterial (PA), microvascular, and venous endothelial cells (ECs), the rate of mitochondrial (mt) DNA repair is predictive of the severity of xanthine oxidase (XO)-induced mtDNA damage and the sensitivity to XO-mediated cell
Autor:
Phillip A. Fields, Cheun-Chen Shen, Glenn L. Wilson, Susan P. LeDoux, Valentina I. Grishko, Anthony L. Gard
Publikováno v:
Glia. 24:304-312
Oligodendrocytes are preferentially sensitive to the toxic, carcinogenic, and teratogenic effects of methylnitrosourea (MNU). The mechanisms responsible for this enhanced sensitivity have not been fully elucidated. One of the most vulnerable cellular