Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Valentina D'Atri"'
Autor:
Thomas Bouvarel, Nadine Bremeyer, Mimi Gao, Wiebke Holkenjans, Terence Hetzel, Reinhard Pell, Valentina D’Atri, Davy Guillarme
Publikováno v:
Molecules, Vol 28, Iss 6, p 2626 (2023)
In the context of targeted radionuclide therapy, antibody-chelator conjugates (ACCs) are an evolving class of antibody-related drugs with promising applications as tumor-targeted pharmaceuticals. Generally, a typical ACC consists of a recombinant mon
Externí odkaz:
https://doaj.org/article/7865fe94d1e24abe94df75fc1f19f254
Autor:
Claire I. Butré, Valentina D’Atri, Hélène Diemer, Olivier Colas, Elsa Wagner, Alain Beck, Sarah Cianferani, Davy Guillarme, Arnaud Delobel
Publikováno v:
Molecules, Vol 28, Iss 6, p 2855 (2023)
In the quest to market increasingly safer and more potent biotherapeutic proteins, the concept of the multi-attribute method (MAM) has emerged from biopharmaceutical companies to boost the quality-by-design process development. MAM strategies rely on
Externí odkaz:
https://doaj.org/article/44e08e4f42d64b4e950744a818aa73ce
Autor:
Amarande Murisier, Valentina D’Atri, Sebastian Pirner, Vincent Larraillet, Szabolcs Fekete, Matthew Lauber, Davy Guillarme
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2315 (2022)
This work illustrates the benefits and limitations of using ultra-short reversed phase liquid chromatography (RPLC) columns for the characterization of various complex bispecific antibodies after prolonged thermal stress at the middle-up level of ana
Externí odkaz:
https://doaj.org/article/b56a7f4ec0ff4897b9a4111ffd99b447
Publikováno v:
Separations, Vol 9, Iss 9, p 243 (2022)
In reversed-phase liquid chromatography (RPLC), the selectivity between major species and minor variants of protein biopharmaceutical products is always limited. Unfortunately, the stationary phase chemistry, type of mobile phase (organic modifier an
Externí odkaz:
https://doaj.org/article/7065b46e03d14421a32db3fed9f4bca2
Publikováno v:
Scientia Pharmaceutica, Vol 90, Iss 1, p 5 (2022)
The objective of this study was to qualitatively evaluate a Fab-targeting ligand preparation containing free thiol groups in the hinge region by using bevacizumab as a model. The evaluation focused on the purification of fragments through a nonaffini
Externí odkaz:
https://doaj.org/article/3f2c58d043664d55b7e980916ee5c41e
Autor:
Bastiaan L. Duivelshof, Steffy Denorme, Koen Sandra, Xiaoxiao Liu, Alain Beck, Matthew A. Lauber, Davy Guillarme, Valentina D’Atri
Publikováno v:
Pharmaceutics, Vol 13, Iss 11, p 1744 (2021)
The identification and accurate quantitation of the various glycoforms contained in therapeutic monoclonal antibodies (mAbs) is one of the main analytical needs in the biopharmaceutical industry, and glycosylation represents a crucial critical qualit
Externí odkaz:
https://doaj.org/article/9ef3402fc0064b6fa7968bd0b3ad2485
Autor:
Evolène Deslignière, Anthony Ehkirch, Bastiaan L. Duivelshof, Hanna Toftevall, Jonathan Sjögren, Davy Guillarme, Valentina D’Atri, Alain Beck, Oscar Hernandez-Alba, Sarah Cianférani
Publikováno v:
Pharmaceuticals, Vol 14, Iss 6, p 498 (2021)
Antibody-drug conjugates (ADCs) are biotherapeutics consisting of a tumor-targeting monoclonal antibody (mAb) linked covalently to a cytotoxic drug. Early generation ADCs were predominantly obtained through non-selective conjugation methods based on
Externí odkaz:
https://doaj.org/article/ca5a96c401214bd8a596a8f7067e6039
Autor:
Szabolcs Fekete, Megane K. Aebischer, Mateusz Imiołek, Tobias Graf, Raphael Ruppert, Matthew Lauber, Valentina D’Atri, Davy Guillarme
Publikováno v:
TrAC Trends in Analytical Chemistry. 164:117088
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c2ef44e631edfc128d88a8df2897e7a
https://doi.org/10.1016/j.trac.2023.117088
https://doi.org/10.1016/j.trac.2023.117088
Publikováno v:
Optimization in HPLC. :57-71
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e6ad79bae85c4a033fa4ece3b9d598f
https://doi.org/10.1002/9783527837489.ch1-4
https://doi.org/10.1002/9783527837489.ch1-4
Autor:
Amarande Murisier, Marie Andrie, Szabolcs Fekete, Matthew Lauber, Valentina D'Atri, Katharina Iwan, Davy Guillarme
Publikováno v:
Journal of Separation Science. 45
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62a0c299999f4cfac3e6bc137db60a36
https://doi.org/10.1002/jssc.202270121
https://doi.org/10.1002/jssc.202270121