Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Valentina Audrito"'
Autor:
Luca Ponzone, Valentina Audrito, Claudia Landi, Enrico Moiso, Chiara Levra Levron, Sara Ferrua, Aurora Savino, Nicoletta Vitale, Massimiliano Gasparrini, Lidia Avalle, Lorenza Vantaggiato, Enxhi Shaba, Beatrice Tassone, Stefania Saoncella, Francesca Orso, Daniele Viavattene, Eleonora Marina, Irene Fiorilla, Giulia Burrone, Youssef Abili, Fiorella Altruda, Luca Bini, Silvia Deaglio, Paola Defilippi, Alessio Menga, Valeria Poli, Paolo Ettore Porporato, Paolo Provero, Nadia Raffaelli, Chiara Riganti, Daniela Taverna, Federica Cavallo, Enzo Calautti
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-17 (2024)
Abstract Background The main drawback of BRAF/MEK inhibitors (BRAF/MEKi)-based targeted therapy in the management of BRAF-mutated cutaneous metastatic melanoma (MM) is the development of therapeutic resistance. We aimed to assess in this context the
Externí odkaz:
https://doaj.org/article/18874da7221f495c92ee85e23df7d535
Autor:
Chiara Cossu, Antonino Di Lorenzo, Irene Fiorilla, Alberto Maria Todesco, Valentina Audrito, Laura Conti
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 456 (2023)
Breast cancer stands as a primary malignancy among women, ranking second in global cancer-related deaths. Despite treatment advancements, many patients progress to metastatic stages, posing a significant therapeutic challenge. Current therapies prima
Externí odkaz:
https://doaj.org/article/d32f009fcad244eab118973e74cff02e
Autor:
Valentina Audrito, Enrico Moiso, Filippo Ugolini, Vincenzo Gianluca Messana, Lorenzo Brandimarte, Ilaria Manfredonia, Simonetta Bianchi, Francesco De Logu, Romina Nassini, Anna Szumera-Ciećkiewicz, Daniela Taverna, Daniela Massi, Silvia Deaglio
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-13 (2022)
Abstract Background Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in nicotinamide adenine dinucleotide (NAD) biosynthesis, is up-regulated in several cancers, including metastatic melanoma (MM). The BRAF oncogene is mutated
Externí odkaz:
https://doaj.org/article/a7800ab7012943b3b4f65fc9c9073fd7
Autor:
Irene Fiorilla, Simona Martinotti, Alberto Maria Todesco, Gregorio Bonsignore, Maria Cavaletto, Mauro Patrone, Elia Ranzato, Valentina Audrito
Publikováno v:
Cells, Vol 12, Iss 16, p 2048 (2023)
Malignant pleural mesothelioma (MPM) is a lethal and rare cancer, even if its incidence has continuously increased all over the world. Asbestos exposure leads to the development of mesothelioma through multiple mechanisms, including chronic inflammat
Externí odkaz:
https://doaj.org/article/d8763738a10d45cca794eb9a9a53708e
Autor:
Sara Boumya, Silvia Fallarini, Sonia Siragusa, Giovanni Petrarolo, Silvio Aprile, Valentina Audrito, Concettina La Motta, Silvia Garavaglia, Laura Moro, Giulia Pinton
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6689 (2023)
Aldehyde dehydrogenase 1A3 (ALDH1A3), one of the three members of the aldehyde dehydrogenase 1A subfamily, has been associated with increased progression and drug resistance in various types of solid tumours. Recently, it has been reported that high
Externí odkaz:
https://doaj.org/article/b9a052f5b30a406eb65bca0552f63ab9
Autor:
Antonella Managò, Valentina Audrito, Francesca Mazzola, Leonardo Sorci, Federica Gaudino, Katiuscia Gizzi, Nicoletta Vitale, Danny Incarnato, Gabriele Minazzato, Alice Ianniello, Antonio Varriale, Sabato D’Auria, Giulio Mengozzi, Gianfranco Politano, Salvatore Oliviero, Nadia Raffaelli, Silvia Deaglio
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The enzyme nicotinate phosphoribosyltransferase (NAPRT) mediates the rate-limiting step in NAD salvage pathway starting from nicotinic acid. Here the authors show that NAPRT can be detected extracellularly, binds to Toll like receptor 4, and activate
Externí odkaz:
https://doaj.org/article/e0822e35c48442ffa058cd85cc49059a
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9985 (2022)
Malignant melanoma represents the most fatal skin cancer due to its aggressive behavior and high metastatic potential. The introduction of BRAF/MEK inhibitors and immune-checkpoint inhibitors (ICIs) in the clinic has dramatically improved patient sur
Externí odkaz:
https://doaj.org/article/e3b85149e5aa4b149ffd6fb0dc33ef0f
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The term NADome refers to the intricate network of intracellular and extracellular enzymes that regulate the synthesis or degradation of nicotinamide adenine dinucleotide (NAD) and to the receptors that engage it. Traditionally, NAD was linked to int
Externí odkaz:
https://doaj.org/article/f7976adf6a624ac689334257e029f915
Autor:
Veronica Fiorito, Anna Lucia Allocco, Sara Petrillo, Elena Gazzano, Simone Torretta, Saverio Marchi, Francesca Destefanis, Consiglia Pacelli, Valentina Audrito, Paolo Provero, Enzo Medico, Deborah Chiabrando, Paolo Ettore Porporato, Carlotta Cancelliere, Alberto Bardelli, Livio Trusolino, Nazzareno Capitanio, Silvia Deaglio, Fiorella Altruda, Paolo Pinton, Simone Cardaci, Chiara Riganti, Emanuela Tolosano
Publikováno v:
Cell Reports, Vol 35, Iss 11, Pp 109252- (2021)
Summary: Heme is an iron-containing porphyrin of vital importance for cell energetic metabolism. High rates of heme synthesis are commonly observed in proliferating cells. Moreover, the cell-surface heme exporter feline leukemia virus subgroup C rece
Externí odkaz:
https://doaj.org/article/97f4f9f8cb914593bbe33253940ba5ea
Autor:
Valentina Audrito
Publikováno v:
EBioMedicine, Vol 62, Iss , Pp 103109- (2020)
Externí odkaz:
https://doaj.org/article/7924460517504fcd9ca2d91f988a7c76