Zobrazeno 1 - 10 of 21 pro vyhledávání: '"Valentina Abet"'
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Inducing Social Self‐Sorting in Organic Cages To Tune The Shape of The Internal Cavity
Autor: Anna G. Slater, Robert Evans, Michael F. Thorne, Peng Cui, Michael J. Bennison, Christopher D. Jones, Valentina Santolini, Kim E. Jelfs, Valentina Abet, Andrew I. Cooper, Xiao-Feng Wu, Marc A. Little, Filip T. Szczypiński, Craig J. Wilson
Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
Angewandte Chemie
Angew Chem Int Ed Engl
Many interesting target guest molecules have low symmetry, yet most methods for synthesising hosts result in highly symmetrical capsules. Methods of generating lower symmetry pores are thus required to maximise the binding affinity in host–guest co
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172ee269253f9a10d83f7d79219069b1
https://doi.org/10.1002/anie.202007571
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3
A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis
Autor: William C. Gordon, Jessica Heap, Amanda R. Pahng, Carolina Burgos, Julio Alvarez-Builla, Hernan A. Bazan, Valentina Abet, Dennis Paul, Alexander J. Ledet, Bokkyoo Jun, Scott Edwards, Nicolas G. Bazan, Surjyadipta Bhattacharjee, Javier Recio
Publikováno v: European Journal of Medicinal Chemistry
Although acetaminophen (ApAP) is one of the most commonly used medicines worldwide, hepatotoxicity is a risk with overdose or in patients with compromised liver function. ApAP overdose is the most common cause of acute fulminant hepatic failure. Oxid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc12dd96d63a0fd0c5ee3f2021b4a1b
https://pubmed.ncbi.nlm.nih.gov/32629335
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4
Prodrug approach: An overview of recent cases
Autor: Fabiana Filace, Valentina Abet, Carolina Burgos, Julio Alvarez-Builla, Javier Recio
Publikováno v: European Journal of Medicinal Chemistry. 127:810-827
In this review we highlight the most modern trends in the prodrug strategy. In drug research and development, the prodrug concept has found a number of useful applications. Selected examples of this approach are provided in this paper and they are cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95f3034581c7f51b35be70689740308e
https://doi.org/10.1016/j.ejmech.2016.10.061
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6
Design, synthesis, biological evaluation and cellular imaging of imidazo[4,5-b]pyridine derivatives as potent and selective TAM inhibitors
Autor: Sandrine Piguel, Ting-Di Wu, François Radvanyi, Jean-Luc Guerquin-Kern, Florent Dufour, Jessy Aziz, Florent Poyer, Valentina Abet, Isabelle Bernard-Pierrot, Sergio Marco Garrido, Tom Baladi, Véronique Stoven
Publikováno v: Bioorganic & Medicinal Chemistry Letters
Bioorganic & Medicinal Chemistry Letters, 2018, 26 (20), pp.5510-5530. ⟨10.1016/j.bmc.2018.09.031⟩
Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2018, 26 (20), pp.5510-5530. ⟨10.1016/j.bmc.2018.09.031⟩
The TAM kinase family arises as a new effective and attractive therapeutic target for cancer therapy, autoimmune and viral diseases. A series of 2,6-disubstituted imidazo[4,5-b]pyridines were designed, synthesized and identified as highly potent TAM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fbad46ed6ac0bb4faf81275e51e4dee
https://hal.archives-ouvertes.fr/hal-03116869
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7
Guanosine and isoguanosine derivatives for supramolecular devices
Autor: Valentina Abet, Raphaël Rodriguez
Publikováno v: New J. Chem.. 38:5122-5128
Guanosine and isoguanosine derivatives can self-assemble by means of hydrogen-bonding, π–π and cation–dipole interactions, yielding supramolecules that have found broad applications in diverse areas, such as material science, medicinal chemistr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b952bb23b40a42ccc6f782c7d5b48f2c
https://doi.org/10.1039/c4nj00665h
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8
Increasing the Dimensionality of Modular Domino Reactions Triggered by Oxidative Cleavage: A Two-Step Protocol Towards a Variety of Stereodefined Complex Oxygen Heterocycles
Autor: Valentina Abet, Rafael R. Castillo, Siméon Arseniyadis, Maurizio Aquino, Pascal Retailleau, Zoila Gandara
Publikováno v: European Journal of Organic Chemistry. 2013:2401-2413
Arylcarbinol- and benzyl-tethered octalin-diols (1/1′), which differ only by the C11 substitution at the angular position, were transformed selectively into original scaffolds of high complexity through a two-step protocol. Overall, the (11S*) conf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8737113309b3223fddf26bc567c51f6f
https://doi.org/10.1002/ejoc.201201483
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9
Modular Construction of Topologically Complex Polycyclic Acetals by Tether-Controlled Domino Reactions
Autor: Maurizio Aquino, Pascal Retailleau, Zoila Gandara, Siméon Arseniyadis, Rafael R. Castillo, Valentina Abet
Publikováno v: European Journal of Organic Chemistry. 2013:2389-2400
Lead tetraacetate mediated oxidative cleavage of octalin-diols (1 and 1′), tethered by variously substituted arenes placed at the angular position (C11), show switchable regioselectivity effects. A highly selective set of regiochemical outcomes can
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3564e4ec2645d7bb9a54b214090f6f29
https://doi.org/10.1002/ejoc.201201481
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