Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Valentina Boeva"'
Autor:
Gwenneg Kerdivel, Floriane Amrouche, Marie-Ange Calmejane, Floriane Carallis, Juliette Hamroune, Constanze Hantel, Jérôme Bertherat, Guillaume Assié, Valentina Boeva
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Adrenocortical carcinoma is rare and aggressive endocrine cancer of the adrenal gland. Within adrenocortical carcinoma, a recently described subtype characterized by a CpG island methylator phenotype (CIMP) has been associated wit
Externí odkaz:
https://doaj.org/article/c76717b318a742faa83e043eb3df2200
Autor:
Cécile Thirant, Agathe Peltier, Simon Durand, Amira Kramdi, Caroline Louis-Brennetot, Cécile Pierre-Eugène, Margot Gautier, Ana Costa, Amandine Grelier, Sakina Zaïdi, Nadège Gruel, Irène Jimenez, Eve Lapouble, Gaëlle Pierron, Déborah Sitbon, Hervé J. Brisse, Arnaud Gauthier, Paul Fréneaux, Sandrine Grossetête, Laura G. Baudrin, Virginie Raynal, Sylvain Baulande, Angela Bellini, Jaydutt Bhalshankar, Angel M. Carcaboso, Birgit Geoerger, Hermann Rohrer, Didier Surdez, Valentina Boeva, Gudrun Schleiermacher, Olivier Delattre, Isabelle Janoueix-Lerosey
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell lines according to their epigenetic landscapes and core regulatory circuitries. However, their relationship and relative contribution in patient tumors re
Externí odkaz:
https://doaj.org/article/04ed19984e944c97b2d0494d3dadfd31
Autor:
Lélia Polit, Gwenneg Kerdivel, Sebastian Gregoricchio, Michela Esposito, Christel Guillouf, Valentina Boeva
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Multiple studies rely on ChIP-seq experiments to assess the effect of gene modulation and drug treatments on protein binding and chromatin structure. However, most methods commonly used for the normalization of ChIP-seq binding in
Externí odkaz:
https://doaj.org/article/c301d6c0cb1f4752a9b84cf9cae998d8
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-17 (2020)
Abstract Chromatin interactions are important for gene regulation and cellular specialization. Emerging evidence suggests many-body spatial interactions play important roles in condensing super-enhancer regions into a cohesive transcriptional apparat
Externí odkaz:
https://doaj.org/article/fc813635d0a04bbfb27cc15186788013
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Motivation: The Cox proportional hazard models are widely used in the study of cancer survival. However, these models often meet challenges such as the large number of features and small sample sizes of cancer data sets. While this issue can be parti
Externí odkaz:
https://doaj.org/article/b971f490aafb41a4b477f53f7a465abd
Autor:
Marie-Ming Aynaud, Olivier Mirabeau, Nadege Gruel, Sandrine Grossetête, Valentina Boeva, Simon Durand, Didier Surdez, Olivier Saulnier, Sakina Zaïdi, Svetlana Gribkova, Aziz Fouché, Ulykbek Kairov, Virginie Raynal, Franck Tirode, Thomas G.P. Grünewald, Mylene Bohec, Sylvain Baulande, Isabelle Janoueix-Lerosey, Jean-Philippe Vert, Emmanuel Barillot, Olivier Delattre, Andrei Zinovyev
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1767-1779.e6 (2020)
Summary: EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade of signaling events leading to cell transformation. However, it remains elusive how genetically homogeneous EwS cells can drive the heterogeneity of transc
Externí odkaz:
https://doaj.org/article/17c804ad436946fd839b98dcb2674815
Autor:
Bieke Decaesteker, Geertrui Denecker, Christophe Van Neste, Emmy M. Dolman, Wouter Van Loocke, Moritz Gartlgruber, Carolina Nunes, Fanny De Vloed, Pauline Depuydt, Karen Verboom, Dries Rombaut, Siebe Loontiens, Jolien De Wyn, Waleed M. Kholosy, Bianca Koopmans, Anke H. W. Essing, Carl Herrmann, Daniel Dreidax, Kaat Durinck, Dieter Deforce, Filip Van Nieuwerburgh, Anton Henssen, Rogier Versteeg, Valentina Boeva, Gudrun Schleiermacher, Johan van Nes, Pieter Mestdagh, Suzanne Vanhauwaert, Johannes H. Schulte, Frank Westermann, Jan J. Molenaar, Katleen De Preter, Frank Speleman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
In high-risk neuroblastoma cases, gains in chromosome 17q are common. Here, the authors investigate the epigenomics and transcriptomics of neuroblastoma, identifying TBX2 as a core regulatory circuitry component enhancing the reactivation of DREAM ta
Externí odkaz:
https://doaj.org/article/536b907629694780b1f507b113373066
Publikováno v:
Cell Reports Methods, 3 (4)
Motivation: With decreasing costs of high-throughput sequencing, more and more studies have started to provide multi-omics molecular profiles of patients with cancer. This has led to various developments of novel survival analysis approaches integrat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3aa1c0b564a2ca54ced85eb01fc2715
https://hdl.handle.net/20.500.11850/609694
https://hdl.handle.net/20.500.11850/609694
Autor:
Samuel Gunz, Gwenneg Kerdivel, Jonas Meirer, Igor Shapiro, Bruno Ragazzon, Floriane Amrouche, Marie-Ange Calmejane, Juliette Hamroune, Sandra Sigala, Alfredo Berruti, Jérôme Bertherat, Guillaume Assié, Constanze Hantel, Valentina Boeva
Adrenocortical carcinoma (ACC) is a rare cancer of the adrenal gland with generally very unfavourable outcome. Two molecular subgroups, C1A and C1B, have been previously identified with a significant association with patient survival. In this work, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc727fa0d4e7b4fc6c8a6db26a4924a9
https://doi.org/10.1101/2023.04.05.535576
https://doi.org/10.1101/2023.04.05.535576
Autor:
Solveig K. Sieberts, Fan Zhu, Javier García-García, Eli Stahl, Abhishek Pratap, Gaurav Pandey, Dimitrios Pappas, Daniel Aguilar, Bernat Anton, Jaume Bonet, Ridvan Eksi, Oriol Fornés, Emre Guney, Hongdong Li, Manuel Alejandro Marín, Bharat Panwar, Joan Planas-Iglesias, Daniel Poglayen, Jing Cui, Andre O. Falcao, Christine Suver, Bruce Hoff, Venkat S. K. Balagurusamy, Donna Dillenberger, Elias Chaibub Neto, Thea Norman, Tero Aittokallio, Muhammad Ammad-ud-din, Chloe-Agathe Azencott, Víctor Bellón, Valentina Boeva, Kerstin Bunte, Himanshu Chheda, Lu Cheng, Jukka Corander, Michel Dumontier, Anna Goldenberg, Peddinti Gopalacharyulu, Mohsen Hajiloo, Daniel Hidru, Alok Jaiswal, Samuel Kaski, Beyrem Khalfaoui, Suleiman Ali Khan, Eric R. Kramer, Pekka Marttinen, Aziz M. Mezlini, Bhuvan Molparia, Matti Pirinen, Janna Saarela, Matthias Samwald, Véronique Stoven, Hao Tang, Jing Tang, Ali Torkamani, Jean-Phillipe Vert, Bo Wang, Tao Wang, Krister Wennerberg, Nathan E. Wineinger, Guanghua Xiao, Yang Xie, Rae Yeung, Xiaowei Zhan, Cheng Zhao, Members of the Rheumatoid Arthritis Challenge Consortium, Jeff Greenberg, Joel Kremer, Kaleb Michaud, Anne Barton, Marieke Coenen, Xavier Mariette, Corinne Miceli, Nancy Shadick, Michael Weinblatt, Niek de Vries, Paul P. Tak, Danielle Gerlag, Tom W. J. Huizinga, Fina Kurreeman, Cornelia F. Allaart, S. Louis Bridges Jr., Lindsey Criswell, Larry Moreland, Lars Klareskog, Saedis Saevarsdottir, Leonid Padyukov, Peter K. Gregersen, Stephen Friend, Robert Plenge, Gustavo Stolovitzky, Baldo Oliva, Yuanfang Guan, Lara M. Mangravite
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Rheumatoid arthritis patients respond differently to anti-TNF treatment. Using community-based challenge, the authors show that currently available data does not reveal meaningful genetic predictors of response to anti-TNF therapy, thus confirming cl
Externí odkaz:
https://doaj.org/article/75f77ca55d0d4c649c320c5fdaffe293