Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Valentina, Stolz"'
1
Akademický článek
Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function
Autor: Valentina Stolz, Rafael de Freitas e Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Boucheron, Wilfried Ellmeier
Publikováno v: eLife, Vol 13 (2024)
FOXP3+ regulatory T cells (Treg cells) are key for immune homeostasis. Here, we reveal that nuclear receptor corepressor 1 (NCOR1) controls naïve and effector Treg cell states. Upon NCOR1 deletion in T cells, effector Treg cell frequencies were elev
Externí odkaz: https://doaj.org/article/99b838b47ea54f90b5aa68be8607b3a8
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2
Akademický článek
NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4+ T Cells
Autor: Daniela Hainberger, Valentina Stolz, Ci Zhu, Michael Schuster, Lena Müller, Patricia Hamminger, Ramona Rica, Darina Waltenberger, Marlis Alteneder, Thomas Krausgruber, Anastasiya Hladik, Sylvia Knapp, Christoph Bock, Michael Trauner, Michael A. Farrar, Wilfried Ellmeier
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
The differentiation of naïve CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific
Externí odkaz: https://doaj.org/article/86713e0c5dfb4380b6c7acd6ce06b46a
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3
Akademický článek
The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells
Autor: Liisa Andersen, Alexandra Franziska Gülich, Marlis Alteneder, Teresa Preglej, Maria Jonah Orola, Narendra Dhele, Valentina Stolz, Alexandra Schebesta, Patricia Hamminger, Anastasiya Hladik, Stefan Floess, Thomas Krausgruber, Thomas Faux, Syed Bilal Ahmad Andrabi, Jochen Huehn, Sylvia Knapp, Tim Sparwasser, Christoph Bock, Asta Laiho, Laura L. Elo, Omid Rasool, Riitta Lahesmaa, Shinya Sakaguchi, Wilfried Ellmeier
Publikováno v: Cell Reports, Vol 29, Iss 13, Pp 4447-4459.e6 (2019)
Summary: Forkhead box protein P3+ (FOXP3+) regulatory T cells (Treg cells) play a key role in maintaining tolerance and immune homeostasis. Here, we report that a T cell-specific deletion of the transcription factor MAZR (also known as PATZ1) leads t
Externí odkaz: https://doaj.org/article/974129bdad3742e980b60d2cd2ed4c8c
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4
Targeting the catalytic activity of HDAC1 in T cells protects against experimental autoimmune encephalomyelitis
Autor: Ci Zhu, Valentina Stolz, Natalija Simonovic, Osamah Al-Rubaye, Terezia Vcelkova, Verena Moos, Lena Hess, Astrid Hagelkruys, Moritz Madern, Wolfgang Reiter, Arabella Meixner, Christoph Bock, Markus Hartl, Ellmeier Ellmeier, Christian Seiser
Histone deacetylases are key epigenetic regulators that control T cell-mediated immunity. A T cell-specific deletion ofHdac1(HDAC1cKO) protects mice against experimental autoimmune encephalomyelitis (EAE). However, it remains elusive whether inhibiti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12f63335e54e471d2d36262cf434fd60
https://doi.org/10.1101/2023.04.14.536700
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7
Akademický článek
The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome.
Autor: Florian Zwolanek, Michael Riedelberger, Valentina Stolz, Sabrina Jenull, Fabian Istel, Afitap Derya Köprülü, Wilfried Ellmeier, Karl Kuchler
Publikováno v: PLoS Pathogens, Vol 10, Iss 12, p e1004525 (2014)
Tec family kinases are intracellular non-receptor tyrosine kinases implicated in numerous functions, including T cell and B cell regulation. However, a role in microbial pathogenesis has not been described. Here, we identified Tec kinase as a novel k
Externí odkaz: https://doaj.org/article/d4e3d108b91340e99051cb53d7486baf
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8
Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases
Autor: Anton Kamnev, Nicole Boucheron, Christian Seiser, Ci Zhu, Patricia Hamminger, Elisa Kaba, Johannes B. Huppa, Wilfried Ellmeier, Loïc Dupré, Christoph Bock, Ramona Rica, Teresa Preglej, Michael Trauner, Ruth Lyck, Marlis Alteneder, René Platzer, Britta Engelhardt, Darina Waltenberger, Valentina Stolz, Luca Marchetti, Jan Bauer, Lisa Sandner
Publikováno v: Journal of Autoimmunity
Journal of Autoimmunity, 2021, 119, pp.102610. ⟨10.1016/j.jaut.2021.102610⟩
Hamminger, Patricia; Marchetti, Luca; Preglej, Teresa; Platzer, René; Zhu, Ci; Kamnev, Anton; Rica, Ramona; Stolz, Valentina; Sandner, Lisa; Alteneder, Marlis; Kaba, Elisa; Waltenberger, Darina; Huppa, Johannes B; Trauner, Michael; Bock, Christoph; Lyck, Ruth; Bauer, Jan; Dupré, Loïc; Seiser, Christian; Boucheron, Nicole; ... (2021). Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases. Journal of autoimmunity, 119, p. 102610. Elsevier 10.1016/j.jaut.2021.102610
International audience; CD4+ T cell trafficking is a fundamental property of adaptive immunity. In this study, we uncover a novel role for histone deacetylase 1 (HDAC1) in controlling effector CD4+ T cell migration, thereby providing mechanistic insi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75bb29835221f575fe8eeffdd74ca545
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