Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Valentina, Molteni"'
Autor:
Roberta Vaccaro, Roberta Ballabio, Valentina Molteni, Laura Ceppi, Benedetta Ferrari, Marco Cantù, Daniele Zaccaria, Carla Vandoni, Rita Bianca Ardito, Mauro Adenzato, Barbara Poletti, Antonio Guaita, Rita Pezzati
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-12 (2020)
Abstract Background Doll therapy is a non-pharmacological intervention for people with dementia aimed to reduce distressing behaviours. Reliable results on the efficacy of Doll therapy for people with dementia are needed. The concept of attachment th
Externí odkaz:
https://doaj.org/article/29ce28bc36164c35a3024ef3964f5791
Autor:
Eloy D. Hernandez, Lianxing Zheng, Young Kim, Bin Fang, Bo Liu, Reginald A. Valdez, William F. Dietrich, Paul V. Rucker, Donatella Chianelli, James Schmeits, Dingjiu Bao, Jocelyn Zoll, Claire Dubois, Glenn C. Federe, Lihao Chen, Sean B. Joseph, Lloyd B. Klickstein, John Walker, Valentina Molteni, Peter McNamara, Shelly Meeusen, David C. Tully, Michael K. Badman, Jie Xu, Bryan Laffitte
Publikováno v:
Hepatology Communications, Vol 3, Iss 8, Pp 1085-1097 (2019)
Farnesoid X receptor (FXR) agonism is emerging as an important potential therapeutic mechanism of action for multiple chronic liver diseases. The bile acid‐derived FXR agonist obeticholic acid (OCA) has shown promise in a phase 2 study in patients
Externí odkaz:
https://doaj.org/article/f910e104a218414a82b33320fcf44859
Autor:
Zhihong Huang, Matthew S. Tremblay, Tom Y.-H. Wu, Qiang Ding, Xueshi Hao, Janine Baaten, Robert Hill, Bo Liu, Shelly Meeusen, Yefen Zou, Shanshan Yan, Yong Jia, Van Nguyen-Tran, Weijun Shen, Ganesh Bhat, Richard Glynne, Bryan Laffitte, Jing Li, Valentina Molteni, Yahu A. Liu
Publikováno v:
ACS Omega, Vol 4, Iss 2, Pp 3571-3581 (2019)
Externí odkaz:
https://doaj.org/article/5cf09ecffc814c04bc864f8859f4158a
Autor:
Srinivasa P S Rao, Suresh B Lakshminarayana, Jan Jiricek, Marcel Kaiser, Ryan Ritchie, Elmarie Myburgh, Frantisek Supek, Tove Tuntland, Advait Nagle, Valentina Molteni, Pascal Mäser, Jeremy C Mottram, Michael P Barrett, Thierry T Diagana
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 28 (2020)
Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of the
Externí odkaz:
https://doaj.org/article/e5e1e471c0c746d79f9d7063a4a2f672
Autor:
Zhihong Huang, Jennifer Shaffer, Badry Bursulaya, Anna Galkin, Rie Kikkawa, Yelena Sarkisova, Su Hua, John Tellew, Yang Yang, Paul Vincent Rucker, Robert Epple, Jiqing Jiang, Nanxin Li, Chianelli Donatella, Jason Roland, Lintong Li, Sergio Briones, Casey J. N. Mathison, Valentina Molteni, Jacqueline Kinyamu-Akunda, Mu-Yun Gao, John Nelson, Christian C. Lee, Yun Feng Xie, Shailaja Kasibhatla, Chun Li
Publikováno v:
ACS Med Chem Lett
[Image: see text] The selective inhibition of RET kinase as a treatment for relevant cancer types including lung adenocarcinoma has garnered considerable interest in recent years and prompted a variety of efforts toward the discovery of small-molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35f9c99597415f677d735f6ab409d8b
https://doi.org/10.1021/acsmedchemlett.1c00450
https://doi.org/10.1021/acsmedchemlett.1c00450
Autor:
Glen Spraggon, Smith Jeffrey M, Chianelli Donatella, Advait Nagle, Christian Wiesmann, Xiaodong Liu, Yongping Xie, Richard J. Sciotti, Todd Groessl, Kevin Johnson, Xianzhong Liu, Celine Be, Christopher Thompson, Yin H. Lai, Jan Jiricek, Patrick J Rudewicz, Brandon S. Pybus, Casey J. N. Mathison, Valentina Molteni, Honnappa Srinivas, Richard Glynne, Jaime Ballard, Agnes Biggart, Diana Caridha, Andreas Hein, Ashley Mitchell Berman, Mu-Yun Gao, Lauren C. Davis, Michael Shapiro, Michael Gibney, Yen Liang Chen, Vince Yeh, Fabian K. Eggimann, Badry Bursulaya, Mara Kreishman-Deitrick, Lerario Isabelle K, Fang Liang, Shilpi Khare, Wendy Richmond, Srinivasa P. S. Rao, Frantisek Supek, Tove Tuntland, Alexandre Luneau
Publikováno v:
Journal of Medicinal Chemistry
Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of GNF6702, a selective inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37584f6654d3dc34b0710ef1ed444634
https://doi.org/10.1021/acs.jmedchem.0c00499
https://doi.org/10.1021/acs.jmedchem.0c00499
Autor:
Tingting Mo, Yefen Zou, Weijun Shen, Zhihong Huang, Xiaoyue Zhang, Qihui Jin, Jing Li, Shifeng Pan, Michael Di Donato, Loren Jon, Andrew M. Schumacher, George Harb, Shanshan Yan, Anwesh Kamireddy, You-Qing Zhang, Tom Y.-H. Wu, Yong Jia, Xueshi Hao, Yahu A. Liu, Richard Glynne, Bryan Laffitte, Brandon Taylor, Peter McNamara, Qiang Ding, Wenqi Gao, Valentina Molteni, Badry Bursalaya, Lisa Deaton, Chun Li
Publikováno v:
ChemMedChem. 15:1562-1570
Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d25eb2a68736314c37d5245dad02a1
https://doi.org/10.1002/cmdc.202000183
https://doi.org/10.1002/cmdc.202000183
Autor:
Bo Liu, Sukwon Ha, H. Michael Petrassi, Kate Jacobsen, George Harb, W. Perry Gordon, Bryan Laffitte, Thanh Lam, Qihui Jin, Yong Jia, Janine E. Baaten, Minhua Qiu, Robert Hill, Shelly Meeusen, Shanshan Yan, Badry Bursulaya, Valentina Molteni, Anwesh Kamireddy, Lisa Deaton, Jianfeng Pan, You-Qing Zhang, Loren Jon, Michael DiDonato, Yahu A. Liu, Shifeng Pan, Andrew M. Schumacher, Tingting Mo, Yefen Zou, Xiaoyue Zhang, Weijun Shen, Karyn Colman, Richard Glynne, Xueshi Hao, Peter McNamara, Vân Nguyen-Tran, Zhicheng Wang, Sheryll Espinola, Bao Nguyen, Tom Y.-H. Wu, Jing Li, Qiang Ding
Publikováno v:
Journal of Medicinal Chemistry. 63:2958-2973
Autoimmune deficiency and destruction in either β-cell mass or function can cause insufficient insulin levels and, as a result, hyperglycemia and diabetes. Thus, promoting β-cell proliferation could be one approach toward diabetes intervention. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222e5ae5085b8fd7b08c90167919a793
https://doi.org/10.1021/acs.jmedchem.9b01624
https://doi.org/10.1021/acs.jmedchem.9b01624
Autor:
Badry Bursulaya, Nanxin Li, Yang Yang, Chianelli Donatella, John Nelson, Casey J. N. Mathison, Valentina Molteni, Sergio Briones, Chun Li, Shailaja Kasibhatla, Christian C. Lee, Jason Roland, Zhihong Huang, Jiqing Jiang, Anna Galkin, John Tellew, Robert Epple, Jacqueline Kinyamu-Akunda, Yelena Sarkisova, Mu-Yun Gao, Rie Kikkawa, Lintong Li, Su Hua, Paul Vincent Rucker, Jennifer Shaffer, Yun Feng Xie
Publikováno v:
ACS Medicinal Chemistry Letters. 11:558-565
RET (REarranged during Transfection) kinase gain-of-function aberrancies have been identified as potential oncogenic drivers in lung adenocarcinoma, along with several other cancer types, prompting the discovery and assessment of selective inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c095921d2621bc9f442ce1c2e02b661
https://doi.org/10.1021/acsmedchemlett.0c00015
https://doi.org/10.1021/acsmedchemlett.0c00015
Autor:
Valentina Molteni, Roberta Vaccaro, Roberta Ballabio, Laura Ceppi, Marco Cantù, Rita B. Ardito, Mauro Adenzato, Barbara Poletti, Antonio Guaita, Rita Pezzati
Publikováno v:
Journal of Clinical Medicine; Volume 11; Issue 21; Pages: 6262
Background: Doll therapy (DT) is a non-pharmacological intervention for the treatment of the behavioural and psychological symptoms of dementia (BPSD). We designed a single-blind randomized controlled trial of the 30-day efficacy of DT in reducing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d05d011ca769682f8ffc8c889e98018
https://hdl.handle.net/2318/1887444
https://hdl.handle.net/2318/1887444
