Data from SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Autor: Nicolas Reynoird, Nima Mosammaparast, Pawel K. Mazur, Pierre Hainaut, Michiel Vermeulen, Yohann Couté, Pascal W.T.C. Jansen, Marianne Tardif, Rebecca Rodell, Jessica Vayr, Ana Morales Benitez, Florent Chuffart, Alexandre G. Casanova, Joshua R. Brickner, Ning Tsao, Tanveer Ahmad, Clement Oyeniran, Gael S. Roth, Simone Hausmann, Valentina Lukinović

Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7aff3a4b13eb09415758e2513af039
https://doi.org/10.1158/2159-8290.c.6549634.v1

Investigating radical pair reaction dynamics of B

Autor: Joanna A, Hughes, Samantha J O, Hardman, Valentina, Lukinović, Jonathan R, Woodward, Alex R, Jones

Publikováno v: Methods in enzymology. 669

B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::aebed52ba5140a99f37e3c9896349efe
https://pubmed.ncbi.nlm.nih.gov/35644174

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Autor: Valentina Lukinović, Simone Hausmann, Gael S. Roth, Clement Oyeniran, Tanveer Ahmad, Ning Tsao, Joshua R. Brickner, Alexandre G. Casanova, Florent Chuffart, Ana Morales Benitez, Jessica Vayr, Rebecca Rodell, Marianne Tardif, Pascal W.T.C. Jansen, Yohann Couté, Michiel Vermeulen, Pierre Hainaut, Pawel K. Mazur, Nima Mosammaparast, Nicolas Reynoird

Publikováno v: Cancer Discovery
Cancer Discovery, In press, ⟨10.1158/2159-8290.CD-21-0205⟩
Cancer Discovery, 12, 2158-2179
Cancer Discovery, 12, 9, pp. 2158-2179

Small cell lung cancer (SCLC) is the most fatal form of lung cancer, with dismal survival, limited therapeutic options, and rapid development of chemoresistance. We identified the lysine methyltransferase SMYD3 as a major regulator of SCLC sensitivit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a6f369ad5cbcb85ed2d339d7aa9050
https://cnrs.hal.science/hal-03759864/document

A peptide array pipeline for the development of Spike-ACE2 interaction inhibitors

Autor: Anand, Chopra, Ali H, Shukri, Hemanta, Adhikary, Valentina, Lukinović, Matthew, Hoekstra, Michael, Cowpland, Kyle K, Biggar

Publikováno v: Peptides. 158:170898

In humans, coronaviruses are the cause of endemic illness and have been the causative agents of more severe epidemics. Most recently, SARS-CoV-2 was the causative agent of the COVID19 pandemic. Thus, there is a high interest in developing therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81bc00b6670b166443dc056ac09ffeb
https://doi.org/10.1016/j.peptides.2022.170898

Lysine Methyltransferases Signaling: Histones are Just the Tip of the Iceberg

Autor: Gaël S. Roth, Nicolas Reynoird, Florent Chuffart, Alexandre G. Casanova, Valentina Lukinović

Publikováno v: Current Protein & Peptide Science
Current Protein & Peptide Science, Bentham Science, 2020, 21 (7), pp.655-674. ⟨10.2174/1871527319666200102101608⟩
Current Protein and Peptide Science
Current Protein and Peptide Science, 2020, 21 (7), pp.655-674. ⟨10.2174/1871527319666200102101608⟩

Protein lysine methylation is a functionally diverse post-translational modification involved in various major cellular processes. Lysine methylation can modulate proteins activity, stability, localization, and/or interaction, resulting in specific d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1c7a233e9f82ae067e0179e143965e
https://hal.archives-ouvertes.fr/hal-02989776