Zobrazeno 1 - 10
of 151
pro vyhledávání: '"Valentin Wittmann"'
Autor:
Jessica Hassenrück, Valentin Wittmann
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 584-601 (2019)
Cyclopropenes have been proven valuable chemical reporter groups for metabolic glycoengineering (MGE). They readily react with tetrazines in an inverse electron-demand Diels–Alder (DAinv) reaction, a prime example of a bioorthogonal ligation reacti
Externí odkaz:
https://doaj.org/article/318325cc5d2b473da90e91d55fdebb83
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The inverse electron-demand Diels-Alder (IEDDA or DAinv) reaction is an emerging bioorthogonal ligation reaction that finds application in all areas of chemistry and chemical biology. In this review we highlight its application in metabolic glycoengi
Externí odkaz:
https://doaj.org/article/c45f445fa809433e849a5aac7ccd1e7a
Autor:
Anne-Katrin Späte, Verena F. Schart, Julia Häfner, Andrea Niederwieser, Thomas U. Mayer, Valentin Wittmann
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 2235-2242 (2014)
Monitoring glycoconjugates has been tremendously facilitated by the development of metabolic oligosaccharide engineering. Recently, the inverse-electron-demand Diels–Alder reaction between methylcyclopropene tags and tetrazines has become a popular
Externí odkaz:
https://doaj.org/article/52faef4e115240c79847455513101fdc
Autor:
Stefan Altaner, Jonathan Puddick, Valerie Fessard, Daniel Feurstein, Ivan Zemskov, Valentin Wittmann, Daniel R. Dietrich
Publikováno v:
Toxins, Vol 11, Iss 7, p 388 (2019)
Cyanobacterial microcystins (MCs), potent serine/threonine-phosphatase inhibitors, pose an increasing threat to humans. Current detection methods are optimised for water matrices with only a few MC congeners simultaneously detected. However, as MC co
Externí odkaz:
https://doaj.org/article/14059bf11f1e4ba59407167aeba8d800
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 8, Iss 1, Pp 819-826 (2012)
A series of six mono-, di-, and trivalent N,N’-diacetylchitobiose derivatives was conveniently prepared by employing a one-pot procedure for Cu(II)-catalyzed diazo transfer and Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) starting from comm
Externí odkaz:
https://doaj.org/article/b843f2c1ed1b4eb992b21e712c107d8a
Publikováno v:
Chemical Society Reviews. 52:510-535
Glycans are involved in numerous biological recognition events. Being secondary gene products, their labeling by genetic methods – comparable to GFP labeling of proteins – is not possible. To overcome this limitation, metabolic glycoengineering (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c39ebbf06374f1cc3473708b327ede
https://doi.org/10.1039/d2cs00764a
https://doi.org/10.1039/d2cs00764a
Autor:
Benesh Joseph, Anandi Kugele, Malte Drescher, Bjarne Silkenath, Sophie Ketter, Valentin Wittmann
Publikováno v:
Chemical Communications (Cambridge, England)
The membrane transporter BtuB is site-directedly spin labelled on the surface of living Escherichia coli via Diels–Alder click chemistry of the genetically encoded amino acid SCO-l-lysine. The previously introduced photoactivatable nitroxide PaNDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755d02ded0f55243f0e6ac85d50c107d
http://europepmc.org/articles/PMC8640571
http://europepmc.org/articles/PMC8640571
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany).
Riboswitches are 5'-untranslated mRNA regions mostly found in bacteria. They are promising drug targets to overcome emerging bacterial resistances against commonly used antibiotics. The glmS riboswitch is unique among the family of riboswitches as it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d37b138c16d7e4be6c1a782a8a908c2
https://pubmed.ncbi.nlm.nih.gov/36326082
https://pubmed.ncbi.nlm.nih.gov/36326082
Autor:
Sachin Handa, Valentin Wittmann, Tharique N. Ansari, Wilfried Braje, Leon H. von Garrel, Deborah Ogulu, Niginia Borlinghaus
Publikováno v:
Green Chemistry. 23:3955-3962
The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enables nucleophilic aromatic subsitution (SNAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95557c985281c295146a8a4a78d3f3d9
https://doi.org/10.1039/d1gc00128k
https://doi.org/10.1039/d1gc00128k
Publikováno v:
Chembiochem
Metabolic glycoengineering (MGE) is an established method to incorporate chemical reporter groups into cellular glycans for subsequent bioorthogonal labeling. The method has found broad application for the visualization and isolation of glycans allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b225658824e5ab4f0ad7885633bff58
http://europepmc.org/articles/PMC8048827
http://europepmc.org/articles/PMC8048827