Zobrazeno 1 - 10
of 378
pro vyhledávání: '"Valentin V. Vlassov"'
Autor:
Ivan V. Chernikov, Irina K. Bachkova, Aleksandra V. Sen’kova, Mariya I. Meschaninova, Innokenty A. Savin, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Cells, Vol 13, Iss 9, p 767 (2024)
Small interfering RNA (siRNA) holds significant therapeutic potential by silencing target genes through RNA interference. Current clinical applications of siRNA have been primarily limited to liver diseases, while achievements in delivery methods are
Externí odkaz:
https://doaj.org/article/df86cd36ee1a45d0b8013056b41765d0
Autor:
Ivan V. Chernikov, Ul’yana A. Ponomareva, Mariya I. Meschaninova, Irina K. Bachkova, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Molecules, Vol 29, Iss 4, p 786 (2024)
Cholesterol siRNA conjugates attract attention because they allow the delivery of siRNA into cells without the use of transfection agents. In this study, we compared the efficacy and duration of silencing induced by cholesterol conjugates of selectiv
Externí odkaz:
https://doaj.org/article/a9812619882e4165812a0c26a5a07816
Autor:
Maxim S. Kupryushkin, Anton V. Filatov, Nadezhda L. Mironova, Olga A. Patutina, Ivan V. Chernikov, Elena L. Chernolovskaya, Marina A. Zenkova, Dmitrii V. Pyshnyi, Dmitry A. Stetsenko, Sidney Altman, Valentin V. Vlassov
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 211-226 (2022)
Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic positions adjacent to the 3′ and 5′ ends were prepared via the Staudinger chemistry, which is
Externí odkaz:
https://doaj.org/article/c83f7d0cf88a49389f1c3548b177f3e2
Autor:
Daniil V. Gladkikh, Aleksandra V. Sen′kova, Ivan V. Chernikov, Tatyana O. Kabilova, Nelly A. Popova, Valery P. Nikolin, Elena V. Shmendel, Mikhail A. Maslov, Valentin V. Vlassov, Marina A. Zenkova, Elena L. Chernolovskaya
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1252 (2021)
In this study, we examined the in vivo toxicity of the liposomes F consisting of 1,26-bis(cholest-5-en-3-yloxycarbonylamino)-7,11,16,20-tetraazahexacosan tetrahydrochloride, lipid-helper 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine and folate lipoco
Externí odkaz:
https://doaj.org/article/df1d1da4a6b245aa93611c072a0d6e74
Autor:
Ivan V. Chernikov, Daniil V. Gladkikh, Mariya I. Meschaninova, Alya G. Ven'yaminova, Marina A. Zenkova, Valentin V. Vlassov, Elena L. Chernolovskaya
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 6, Iss , Pp 209-220 (2017)
Chemical modifications are an effective way to improve the therapeutic properties of small interfering RNAs (siRNAs), making them more resistant to degradation in serum and ensuring their delivery to target cells and tissues. Here, we studied the car
Externí odkaz:
https://doaj.org/article/a745375785e3445691e0772e40b58dd1
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Small double-stranded RNAs with certain sequence motifs are able to interact with pattern-recognition receptors and activate the innate immune system. Recently, we identified a set of short double-stranded 19-bp RNA molecules with 3-nucleotide 3′-o
Externí odkaz:
https://doaj.org/article/a7622dbb931c46e79269f161290b3e27
Autor:
Julia A. Filippova, Anastasiya M. Matveeva, Evgenii S. Zhuravlev, Evgenia A. Balakhonova, Daria V. Prokhorova, Sergey J. Malanin, Raihan Shah Mahmud, Tatiana V. Grigoryeva, Ksenia S. Anufrieva, Dmitry V. Semenov, Valentin V. Vlassov, Grigory A. Stepanov
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
CRISPR technologies are nowadays widely used for targeted knockout of numerous protein-coding genes and for the study of various processes and metabolic pathways in human cells. Most attention in the genome editing field is now focused on the cleavag
Externí odkaz:
https://doaj.org/article/db7e89ffdcf348808cadf52f37b9b273
Autor:
Olga A. Patutina, Svetlana K. Miroshnichenko, Nadezhda L. Mironova, Aleksandra V. Sen’kova, Elena V. Bichenkova, David J. Clarke, Valentin V. Vlassov, Marina A. Zenkova
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Control of the expression of oncogenic small non-coding RNAs, notably microRNAs (miRNAs), is an attractive therapeutic approach. We report a design platform for catalytic knockdown of miRNA targets with artificial, sequence-specific ribonucleases. mi
Externí odkaz:
https://doaj.org/article/f4b56814e4af47f7b059a8be3d18d8f9
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Small interfering RNAs (siRNAs) acting via RNA interference mechanisms are able to recognize a homologous mRNA sequence in the cell and induce its degradation. The main problems in the development of siRNA-based drugs for therapeutic use are the low
Externí odkaz:
https://doaj.org/article/8c486dde09ce4b9c8b2b8dd5565edf96
Autor:
O. A. Patutina, Dmitry A. Stetsenko, Elena L. Chernolovskaya, Marina A. Zenkova, N. L. Mironova, Anton V. Filatov, Ivan V. Chernikov, Dmitrii V. Pyshnyi, Maxim S. Kupryushkin, Sidney Altman, Valentin V. Vlassov
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 27, Iss, Pp 211-226 (2022)
Molecular Therapy: Nucleic Acids, Vol 27, Iss, Pp 211-226 (2022)
Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic positions adjacent to the 3′ and 5′ ends were prepared via the Staudinger chemistry, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9e66637a176c9251c315ae6ad4f92c9
https://doi.org/10.1016/j.omtn.2021.11.025
https://doi.org/10.1016/j.omtn.2021.11.025