Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Valentin Sottas"'
Autor:
Ninda Syam, Stéphanie Chatel, Lijo Cherian Ozhathil, Valentin Sottas, Jean‐Sébastien Rougier, Alban Baruteau, Estelle Baron, Mohamed‐Yassine Amarouch, Xavier Daumy, Vincent Probst, Jean‐Jacques Schott, Hugues Abriel
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 5 (2016)
BackgroundTransient receptor potential melastatin member 4 (TRPM4) is a nonselective cation channel. TRPM4 mutations have been linked to cardiac conduction disease and Brugada syndrome. The mechanisms underlying TRPM4‐dependent conduction slowing a
Externí odkaz:
https://doaj.org/article/86d158a96cb74f1c8ec84708488e21c6
Autor:
Geoffrey S. Pitt, Valentin Sottas, Zizun Wang, Daniela Ross-Kaschitza, Sarah H. Vermij, Jean-Sébastien Rougier, Hugues Abriel, Elena Zaklyazminskaya, Anna Shestak, Andy Hudmon
The cardiac voltage-gated sodium channel Nav1.5 conducts the rapid inward sodium current crucial for cardiomyocyte excitability. Loss-of-function mutations in its gene SCN5A are linked to cardiac arrhythmias such as Brugada Syndrome (BrS). Several Br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::146794d8059b25a503a6f70c98cf4080
https://doi.org/10.1101/2020.06.02.129288
https://doi.org/10.1101/2020.06.02.129288
Autor:
Valentin Sottas, Hugues Abriel
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1863:1791-1798
During the past two decades, many pathological genetic variants in SCN5A, the gene encoding the pore-forming subunit of the cardiac (monomeric) sodium channel Na(v)1.5, have been described. Negative dominance is a classical genetic concept involving
Autor:
Michael Bartolf-Kopp, Markus Hecker, Mihnea C. Trache, Sidney B. Cambridge, Nina D. Ullrich, Valentin Sottas, Carl-Mattheis Wahl
Publikováno v:
Journal of molecular and cellular cardiology. 120
The therapeutic potential of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is limited by immature functional features including low impulse propagation and reduced cell excitability. Key players regulating electrical activity are vo
Autor:
Leonid M. Makarov, Jan P. Kucera, Valentin Sottas, Elena Zaklyazminskaya, Anna Shestak, Hugues Abriel, Jean-Sébastien Rougier, Florian Jousset
Publikováno v:
Journal of Cardiovascular Electrophysiology. 24:1037-1046
Hundreds of genetic variants in SCN5A, the gene coding for the pore-forming subunit of the cardiac sodium channel, Na(v) 1.5, have been described in patients with cardiac channelopathies as well as in individuals from control cohorts. The aim of this
Autor:
Hugues Abriel, Valentin Sottas, Vincent Probst, Jean-Sébastien Rougier, Stéphanie Chatel, Alban Baruteau, Mohamed Yassine Amarouch, Ninda Syam, Lijo Cherian Ozhathil, Estelle Baron, Jean-Jacques Schott, Xavier Daumy
Publikováno v:
Journal of the American Heart Association
Journal of the American Heart Association, Wiley-Blackwell, 2016, Equipe 3, 5 (5), ⟨10.1161/JAHA.114.001625⟩
Syam, Ninda Ratna Maharani; Chatel, Stéphanie; Ozhathil, Lijo Cherian; Sottas, Valentin; Rougier, Jean-Sébastien; Baruteau, Alban; Baron, Estelle; Amarouch, Mohamed Yassine; Daumy, Xavier; Probst, Vincent; Schott, Jean-Jacques; Abriel, Hugues (2016). Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block. Journal of the American Heart Association, 5(5) American Heart Association 10.1161/JAHA.114.001625
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Journal of the American Heart Association, Wiley-Blackwell, 2016, Equipe 3, 5 (5), ⟨10.1161/JAHA.114.001625⟩
Syam, Ninda Ratna Maharani; Chatel, Stéphanie; Ozhathil, Lijo Cherian; Sottas, Valentin; Rougier, Jean-Sébastien; Baruteau, Alban; Baron, Estelle; Amarouch, Mohamed Yassine; Daumy, Xavier; Probst, Vincent; Schott, Jean-Jacques; Abriel, Hugues (2016). Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block. Journal of the American Heart Association, 5(5) American Heart Association 10.1161/JAHA.114.001625
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Transient receptor potential melastatin member 4 ( TRPM 4) is a nonselective cation channel. TRPM 4 mutations have been linked to cardiac conduction disease and Brugada syndrome. The mechanisms underlying TRPM 4‐dependent conduction slow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b9b5ddb72aca2a1ea842d17661f7b1
Publikováno v:
Biochemical Pharmacology. 84:873-881
The transient receptor potential channel (TRP) family comprises at least 28 genes in the human genome. These channels are widely expressed in many different tissues, including those of the cardiovascular system. The transient receptor potential chann
Autor:
Hugues Abriel, Valentin Sottas
Publikováno v:
Circulation: Cardiovascular Genetics. 7:97-99
> If you do not expect the unexpected, you will not find it, for it is not to be reached by search or trail > > –Heraclitus of Ephesus, c.535-c.475 BC In human genetics, autosomal dominant disorders are characterized by the fact that only 1 mutated
Autor:
Mickael Poidevin, Bok Luel Lee, Aurélien Guillou, Bruno Lemaitre, Valentin Sottas, Hyun-Mi Kwon, Nicolas Buchon
Publikováno v:
Proceedings of the National Academy of Sciences. 106:12442-12447
The Drosophila Toll receptor does not interact directly with microbial determinants, but is instead activated by a cleaved form of the cytokine-like molecule Spätzle. During the immune response, Spätzle is processed by complex cascades of serine pr
Publikováno v:
Biophysical Journal. 112:19a
The cardiogenic potential of stem-cell derived cardiomyocytes (iPSC-CM) and their prospective use for cardiac cell therapy crucially depends on their excitability and functional integration in myocardial tissue. Indeed, previous studies from our grou