From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs

Autor: Valentin L'Hôte, Carl Mann, Jean-Yves Thuret

Publikováno v: Open Biology, Vol 12, Iss 9 (2022)

Senescence is a cellular stress response that involves prolonged cell survival, a quasi-irreversible proliferative arrest and a modification of the transcriptome that sometimes includes inflammatory gene expression. Senescent cells are resistant to a

Externí odkaz: https://doaj.org/article/536b07cdd07a4d76a19531ae600a4a4f

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells

Autor: Mara Doimo, Sanna Abrahamsson, Valentin L’Hôte, Mama Ndi, Rabindra Nath Das, Koit Aasumets, Andreas Berner, Steffi Goffart, Jaakko L.O. Pohjoismäki, Marcela Dávila López, Erik Chorell, Sjoerd Wanrooij

Mitochondrial DNA (mtDNA) replication stalling is considered an initial step in the formation of mtDNA deletions that associate with genetic inherited disorders and aging. However, the molecular details of how stalled replication forks lead to mtDNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9bda214bb0abccd1297c56c02bdab69
https://doi.org/10.1101/2022.06.08.495283

A complementary chemical probe approach towards customized studies of G-quadruplex DNA structures in live cells

Autor: Erik Chorell, Måns Andreasson, Mara Doimo, Valentin L'Hôte, Prasad Bagineni, Sjoerd Wanrooij

G-quadruplex (G4) DNA structures are implicated in central biological processes and are considered promising therapeutic targets because of their links to human diseases such as cancer. However, functional details of how, when, and why G4 DNA structu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa44d781a5eecb11abad6512dd25a9e
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-193064

Glucocorticoids delay RAF-induced senescence promoted by EGR1

Autor: Carl Mann, Valentin L’Hôte, Gueorgui Kratassiouk, Jean-François Deleuze, Jean-Yves Thuret, Robert Olaso, Cyril Carvalho, Régis Courbeyrette, Céline Derbois, Guillaume Pinna, Cyril Denby-Wilkes, Jean-Christophe Cintrat

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2019, 132 (16), pp.jcs230748. ⟨10.1242/jcs.230748⟩
Journal of Cell Science, 2019, 132 (16), pp.jcs230748. ⟨10.1242/jcs.230748⟩

Expression of hyperactive RAF kinases, such as the oncogenic B-RAF-V600E mutant, in normal human cells triggers a proliferative arrest that blocks tumor formation. We discovered that glucocorticoids delayed the entry into senescence induced by B-RAF-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b99054402c48a824c1dd1ab686e74d25
https://hal.archives-ouvertes.fr/hal-02330078