Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Valentin K, Gribkoff"'
Autor:
Jing Wu, Lynda El-Hassar, Dibyadeep Datta, Merrilee Thomas, Yalan Zhang, David P. Jenkins, Nicholas J. DeLuca, Manavi Chatterjee, Valentin K. Gribkoff, Amy F.T. Arnsten, Leonard K. Kaczmarek
The ability of monkeys and rats to carry out spatial working memory tasks has been shown to depend on the persistent firing of pyramidal cells in the prefrontal cortex (PFC), arising from recurrent excitatory connections on dendritic spines. These sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85871bd76865359c3abb76c6ad7315e0
https://doi.org/10.21203/rs.3.rs-2870277/v1
https://doi.org/10.21203/rs.3.rs-2870277/v1
Publikováno v:
Advances in Neurobiology ISBN: 9783031210532
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43db6eec277c1b0a2698e4d0fe577f3e
https://doi.org/10.1007/978-3-031-21054-9_11
https://doi.org/10.1007/978-3-031-21054-9_11
Publikováno v:
ACS omega, vol 7, iss 43
Monitoring the anti-epileptic drug carbamazepine (CBZ) is crucial for proper dosing, optimizing a patient's clinical outcome, and managing their medication regimen. Due to its narrow therapeutic window and concentration-related toxicity, CBZ is presc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee766a2d9a8137a5599819ac5209b1f1
https://escholarship.org/uc/item/04k962d3
https://escholarship.org/uc/item/04k962d3
Publikováno v:
Advances in pharmacology (San Diego, Calif.). 94
Glucagon-like peptide-1 (GLP-1) receptor agonists are extensively used in type 2 diabetic patients for the effective control of hyperglycemia. It is now clear from outcomes trials that this class of drugs offers important additional benefits to these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a810e93e5562556c26d0603e1594a0d
https://pubmed.ncbi.nlm.nih.gov/35659373
https://pubmed.ncbi.nlm.nih.gov/35659373
Publikováno v:
Advances in Pharmacology ISBN: 9780323910873
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3e2eb18e44021635c90a3ac06608997
https://doi.org/10.1016/bs.apha.2022.02.005
https://doi.org/10.1016/bs.apha.2022.02.005
Publikováno v:
Biochemical Pharmacology. 208:115413
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e4f26ae7dc9acd4e8722b00ef3a4015
https://doi.org/10.1016/j.bcp.2023.115413
https://doi.org/10.1016/j.bcp.2023.115413
Publikováno v:
Neuropharmacology. 120:11-19
An important goal of biomedical research is to translate basic research findings into useful medical advances. In the field of neuropharmacology this requires understanding disease mechanisms as well as the effects of drugs and other compounds on neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbf9591dd93a08365a6948660cb1a54
https://doi.org/10.1016/j.neuropharm.2016.03.021
https://doi.org/10.1016/j.neuropharm.2016.03.021
Autor:
Sana Sohail, Gulan N. Xu, Paige Miranda, Erin Song, Richard J. Levy, Charles Effman, Rongmin Chen, Nikita Mehta, Elizabeth A. Jonas, Harshvardhan Rolyan, Samuel Effman, Jing Wu, Pawel Licznerski, Nelli Mnatsakanyan, Han-A Park, Morven Graham, Lucas Brandao, Jorge Salcedo, Nicole Cruz-Reyes, Amber Braker, Valentin K. Gribkoff
Publikováno v:
Cell
Loss of the gene (Fmr1) encoding Fragile X mental retardation protein (FMRP) causes increased mRNA translation and aberrant synaptic development. We find neurons of the Fmr1-/y mouse have a mitochondrial inner membrane leak contributing to a "leak me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91d768bdd2326fc83721091fd0f5ed3
https://doi.org/10.1016/j.cell.2020.07.008
https://doi.org/10.1016/j.cell.2020.07.008
Autor:
Vincenzo Calandra, Steven I. Dworetzky, Yong-Jin Wu, Ronald J. Knox, William Fitzpatrick, Huan He, JoAnne E Natale, David G. Harden, Li-Qiang Sun, Carl D. Davis, David Weaver, Frederic Machet, Joseph Polino, John E. Starrett, Karen Heman, Ping Chen, Valentin K. Gribkoff, Christopher G. Boissard, Clotilde Bourin, Charles M. Conway, Jie Chen, Mark W. Thompson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:6188-6191
Acrylamide (S)-6, a potent and efficacious KCNQ2 (Kv7.2) opener, demonstrated significant activity in two models of neuropathic pain and in the formalin test, suggesting that KCNQ2 openers may be useful in the treatment of neuropathic pain including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c81071ad17f712c14b9149ad6dfe150
https://doi.org/10.1016/j.bmcl.2013.08.092
https://doi.org/10.1016/j.bmcl.2013.08.092
This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approache