Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Valentin Gorboulev"'
Autor:
Thomas D. Mueller, Valentin Gorboulev, Frank Bernhard, Hermann Koepsell, Thorsten Keller, Volker Dötsch
Publikováno v:
Molecular Pharmacology. 95:169-182
Organic cation transporters OCT1 (SLC22A1) and OCT2 (SLC22A2) are critically involved in absorption and excretion of diverse cationic drugs. Because drug-drug interactions at these transporters may induce adverse drug effects in patients, in vitro te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9bbe813ed755cc2dba7054ae3e2629
https://doi.org/10.1124/mol.118.113498
https://doi.org/10.1124/mol.118.113498
Autor:
Ilona Zilkowski, Valentin Gorboulev, Thorsten Keller, Nadine Schäfer, Jürgen Groll, Chakravarthi Chintalapati, Hermann Koepsell, Dietmar Geiger, Thomas D. Mueller, Maike Veyhl-Wichmann
Publikováno v:
Molecular Pharmacology. 90:508-521
Na+-d-glucose cotransporter 1 (SGLT1) is rate-limiting for glucose absorption in the small intestine. Shortly after intake of glucose-rich food, SGLT1 abundance in the luminal membrane of the small intestine is increased. This upregulation occurs via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a43b3659863ab7629eb04ef9700687
https://doi.org/10.1124/mol.116.104521
https://doi.org/10.1124/mol.116.104521
Autor:
Valentin Gorboulev, Jürgen Groll, Hermann Koepsell, Smriti Singh, Helmut Kipp, Rüdiger Pipkorn, Marçal Pastor-Anglada, Chakravarthi Chintalapati, Alexandra Vernaleken, Maike Veyhl-Wichmann, Alexandra Friedrich, Thorsten Keller
Publikováno v:
Molecular Pharmacology. 89:118-132
Cellular uptake adapts rapidly to physiologic demands by changing transporter abundance in the plasma membrane. The human gene RSC1A1 codes for a 67-kDa protein named RS1 that has been shown to induce downregulation of the sodium-D-glucose cotranspor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94a333f311a145f97a3db8191421080c
https://doi.org/10.1124/mol.115.101162
https://doi.org/10.1124/mol.115.101162
Autor:
Marleen Julia Meyer, Valentin Gorboulev, Christoph Michael Albert, Ursula Roth, Mladen Vassielev Tzvetkov, Thomas D. Mueller, Hermann Koepsell, Saba Rehman
Publikováno v:
Molecular pharmacology. 93(4)
The effects of mutations in the modeled outward-open cleft of rat organic cation transporter 1 (rOCT1) on affinities of substrates and inhibitors were investigated. Human embryonic kidney 293 cells were stably transfected with rOCT1 or rOCT1 mutants,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7162d157340326eb011f2c2b0be67e7c
https://pubmed.ncbi.nlm.nih.gov/29339398
https://pubmed.ncbi.nlm.nih.gov/29339398
Autor:
Cristina Arimany-Nardi, Ekaitz Errasti-Murugarren, Gerard Minuesa, Javier Martinez-Picado, Valentin Gorboulev, Marçal Pastor-Anglada, Hermann Koepsell
Publikováno v:
British Journal of Pharmacology. 171:3868-3880
Background and Purpose Inhibitors of DNA methyltransferases (DNMTs), such as azacytidine, decitabine and zebularine, are used for the epigenetic treatment of cancer. Their action may depend upon their translocation across the plasma membrane. The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d96c201107456fc277007bd9141c37f
https://doi.org/10.1111/bph.12748
https://doi.org/10.1111/bph.12748
Autor:
Frank Thévenod, Irina Schatz, Thorsten Keller, Giuliano Ciarimboli, Rouvier Al-Monajjed, Hermann Koepsell, Natascha A. Wolff, Valentin Gorboulev, Wing-Kee Lee, Marcus Leistner
Publikováno v:
Molecular Pharmaceutics. 10:3045-3056
Polyspecific organic cation transporter Oct2 from rat (gene Slc22A2) has been previously shown to transport Cs(+). Here we report that human OCT2 (hOCT2) is able to transport Cd(2+) showing substrate saturation with a Michaelis-Menten constant (Km) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e67937e59e598b6d4ff89869f74fde
https://doi.org/10.1021/mp400113d
https://doi.org/10.1021/mp400113d
Autor:
Dirk Klessen, Stephan Scherneck, Maike Veyhl-Wichmann, Stefan Wiese, Aruna Srinivasan, Alexandra Friedrich, Helen E. Parker, Helmut Kipp, Hermann Koepsell, Fiona M. Gribble, Frank Reimann, Alexander Jaschke, Robyn Cunard, Timo Rieg, Rexhep Rexhepaj, Ivan Sabolić, Michael Sendtner, Daniela Balen, Volker Vallon, Davorka Breljak, Florian Lang, Valentin Gorboulev, Annette Schürmann
Publikováno v:
Diabetes
Diabetes, vol 61, iss 1
Diabetes, vol 61, iss 1
To clarify the physiological role of Na+-d-glucose cotransporter SGLT1 in small intestine and kidney, Sglt1−/− mice were generated and characterized phenotypically. After gavage of d-glucose, small intestinal glucose absorption across the brush-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9de56b6c6750e700615e9a16dd4e60
http://europepmc.org/articles/PMC3237647
http://europepmc.org/articles/PMC3237647
Autor:
Stefan Koppatz, Zeljko Uzelac, Harald H. Sitte, Carola Hunte, Hermann Koepsell, Dmitry Gorbunov, Thorsten Keller, Volker Dötsch, Valentin Gorboulev, Christophe Wirth, Brigitte Egenberger, Frank Bernhard
Publikováno v:
Journal of Biological Chemistry. 286:37874-37886
Polyspecific organic anion transporters (OATs) and organic cation transporters (OCTs) of the SLC22 transporter family play a pivotal role in absorption, distribution, and excretion of drugs. Polymorphisms in these transporters influence therapeutic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fca6c328793c3cc30829c8eb4f35c91
https://doi.org/10.1074/jbc.m111.289330
https://doi.org/10.1074/jbc.m111.289330
Publikováno v:
Molecular Pharmacology. 76:275-289
We have shown previously that Leu447 and Gln448 in the transmembrane helix (TMH) 10 of rat organic cation transporter rOCT1 are critical for inhibition of cation uptake by corticosterone. Here, we tested whether the affinity of corticosterone is diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22acf1bef68acfcb3e3b58c417ed0f67
https://doi.org/10.1124/mol.109.054783
https://doi.org/10.1124/mol.109.054783
Autor:
Volker Dötsch, Carola Hunte, Valentin Gorboulev, Thorsten Keller, Frank Bernhard, Daniel Schwarz, Hermann Prof Dr. Koepsell
Publikováno v:
Biochemistry. 47:4552-4564
Polyspecific organic cation and anion transporters of the SLC22 protein family are critically involved in absorption and excretion of drugs. To elucidate transport mechanisms, functional and biophysical characterization of purified transporters is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94844612880fee1fbce3d91b42aae2a
https://doi.org/10.1021/bi800060w
https://doi.org/10.1021/bi800060w