Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Valentin Cena"'
Autor:
Valentin Ceña, M. Isabel Lucena
Publikováno v:
Pharmacological Research, Vol 206, Iss , Pp 107265- (2024)
Externí odkaz:
https://doaj.org/article/729ad685f28a4183a82f6cac5cede776
Publikováno v:
Pharmacological Research, Vol 201, Iss , Pp 107102- (2024)
Since its discovery in 1998, the use of small interfering RNA (siRNA) has been increasing in biomedical studies because of its ability to very selectively inhibit the expression of any target gene. Thus, siRNAs can be used to generate therapeutic com
Externí odkaz:
https://doaj.org/article/4bb6c28c7ace4b75851938fcd182365b
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 439 (2024)
Over the last few years, the development of nanotechnology has allowed for the synthesis of many different nanostructures with controlled sizes, shapes, and chemical properties, with dendrimers being the best-characterized of them. In this review, we
Externí odkaz:
https://doaj.org/article/340715248c4048948313d7e08c4d7b25
Dendrimers are important molecules that are currently undergoing investigation for use in a variety of different biomedical applications. This book explores the use of dendrimers for a variety of potential functions, including antiamyloidogenic agent
Publikováno v:
Pharmaceutics, Vol 15, Iss 6, p 1698 (2023)
The design of colchicine site ligands on tubulin has proven to be a successful strategy to develop potent antiproliferative drugs against cancer cells. However, the structural requirements of the binding site endow the ligands with low aqueous solubi
Externí odkaz:
https://doaj.org/article/b9b06ce8bf9b4492bb9e9253040d8cbf
Autor:
Shahin Sarowar, Davide Cirillo, Pablo Játiva, Mette Hartmark Nilsen, Sarah-Muheha Anni Otragane, Jan Heggdal, Frode Selheim, Valentín Ceña, Hans-René Bjørsvik, Per Øyvind Enger
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Metastatic tumors with moderate radiosensitivity account for most cancer-related deaths, highlighting the limitations of current radiotherapy regimens. The xCT-inhibitor sulfasalazine (SAS) sensitizes cancer cells to radiotherapy by blocking cystine
Externí odkaz:
https://doaj.org/article/dd9a9a4b0be142ba87cf11186be1469d
Autor:
Cristina de la Torre, Pablo Játiva, Inmaculada Posadas, Darío Manzanares, José L. Jiménez Blanco, Carmen Ortiz Mellet, José Manuel García Fernández, Valentín Ceña
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2424 (2022)
Synthetic double-stranded small interfering RNAs (siRNAs) mimic interference RNAs (RNAi) and can bind target mRNAs with a high degree of specificity, leading to selective knockdown of the proteins they encode. However, siRNAs are very labile and must
Externí odkaz:
https://doaj.org/article/e1323517ef9e4ff0a4c10937bad41467
Autor:
Alba Martín-Moreno, José L. Jiménez Blanco, Jamie Mosher, Douglas R. Swanson, José M. García Fernández, Ajit Sharma, Valentín Ceña, María Angeles Muñoz-Fernández
Publikováno v:
Pharmaceutics, Vol 12, Iss 7, p 656 (2020)
Finding a functional cure for HIV-1 infection will markedly decrease the social and economic burden of this disease. In this work, we have taken advantage of the antigen presenting cell role of human dendritic cells (DCs) to try to induce an immune r
Externí odkaz:
https://doaj.org/article/afba7771646543e397bf25610c4d36e3
Autor:
Darío Manzanares, Valentín Ceña
Publikováno v:
Pharmaceutics, Vol 12, Iss 4, p 371 (2020)
Nanoparticles (NPs) and submicron particles are increasingly used as carriers for delivering therapeutic compounds to cells. Their entry into the cell represents the initial step in this delivery process, being most of the nanoparticles taken up by e
Externí odkaz:
https://doaj.org/article/f4c8c5827bc047418a22053c21eb9399
Autor:
Laura Gallego-Yerga, Inmaculada Posadas, Cristina de la Torre, Jesús Ruiz-Almansa, Francesco Sansone, Carmen Ortiz Mellet, Alessandro Casnati, José M. García Fernández, Valentín Ceña
Publikováno v:
Frontiers in Pharmacology, Vol 8 (2017)
Giant amphiphiles encompassing a hydrophilic β-cyclodextrin (βCD) component and a hydrophobic calix[4]arene (CA4) module undergo self-assembly in aqueous media to afford core-shell nanospheres or nanocapsules, depending on the nanoprecipitation pro
Externí odkaz:
https://doaj.org/article/10552c482df643388ad61375e402dc7e