Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Valentin Ceña"'
Autor:
Valentin Ceña, M. Isabel Lucena
Publikováno v:
Pharmacological Research, Vol 206, Iss , Pp 107265- (2024)
Externí odkaz:
https://doaj.org/article/729ad685f28a4183a82f6cac5cede776
Publikováno v:
Molecules, Vol 23, Iss 8, p 2028 (2018)
Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation o
Externí odkaz:
https://doaj.org/article/a54250abce134adc82e51327bebccd88
Autor:
Serge Mignani, João Rodrigues, René Roy, Xiangyang Shi, Valentin Ceña, Saïd El Kazzouli, Jean-Pierre Majoral
Publikováno v:
Drug Discovery Today Biosilico
Drug Discovery Today Biosilico, 2019, 24 (5), pp.1184-1192. ⟨10.1016/j.drudis.2019.03.001⟩
Drug Discovery Today Biosilico, Elsevier, 2019, 24 (5), pp.1184-1192. ⟨10.1016/j.drudis.2019.03.001⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Drug Discovery Today Biosilico, 2019, 24 (5), pp.1184-1192. ⟨10.1016/j.drudis.2019.03.001⟩
Drug Discovery Today Biosilico, Elsevier, 2019, 24 (5), pp.1184-1192. ⟨10.1016/j.drudis.2019.03.001⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
International audience; In nanomedicine, the widespread concern of nanoparticles in general, and dendrimers, in particular, is the analysis of key in-vivo physicochemical parameters to ensure the preclinical and clinical development of ‘safe’ bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba393238c708a39984b82cfa4fd9bdd
https://doi.org/10.1016/j.drudis.2019.03.001
https://doi.org/10.1016/j.drudis.2019.03.001
Publikováno v:
International Journal of Molecular Sciences. 23:6808
Parkinson’s disease is a neurodegenerative condition initially characterized by the presence of tremor, muscle stiffness and impaired balance, with the deposition of insoluble protein aggregates in Lewy’s Bodies the histopathological hallmark of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4973e2463e7c676eddebe498e59f32
https://doi.org/10.3390/ijms23126808
https://doi.org/10.3390/ijms23126808
Publikováno v:
Pharmacological Research, Vol 201, Iss , Pp 107102- (2024)
Since its discovery in 1998, the use of small interfering RNA (siRNA) has been increasing in biomedical studies because of its ability to very selectively inhibit the expression of any target gene. Thus, siRNAs can be used to generate therapeutic com
Externí odkaz:
https://doaj.org/article/4bb6c28c7ace4b75851938fcd182365b
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 439 (2024)
Over the last few years, the development of nanotechnology has allowed for the synthesis of many different nanostructures with controlled sizes, shapes, and chemical properties, with dendrimers being the best-characterized of them. In this review, we
Externí odkaz:
https://doaj.org/article/340715248c4048948313d7e08c4d7b25
Autor:
Valentin, Ceña, Giuseppe, Bardi, Antonio, Nunes, Lisa, Gherardini, Katie, Bates, Al Jamal, Khuloud T., Claire, Gaillard, Prato, Maurizio, Alberto, Bianco, Tommaso, Pizzorusso, Kostas, Kostarelos
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80964 (2013)
PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e80964. ⟨10.1371/journal.pone.0080964⟩
PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e80964. ⟨10.1371/journal.pone.0080964⟩
The potential use of functionalized carbon nanotubes (f-CNTs) for drug and gene delivery to the central nervous system (CNS) and as neural substrates makes the understanding of their in vivo interactions with the neural tissue essential. The aim of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2ad7fa4292a9c2ebb8e6dfdf5ce861
http://europepmc.org/articles/PMC3832421?pdf=render
http://europepmc.org/articles/PMC3832421?pdf=render
Publikováno v:
Experimental Neurology. 196:120-125
Status epilepticus (SE) represents a serious medical emergency that can produce long-lasting brain damage as well as cognitive and memory deficits. However, the mechanisms that determine the emergence of SE from a single seizure and the prolonged dur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722defd6d5a65d48a6c828ae19df26e2
https://doi.org/10.1016/j.expneurol.2005.07.013
https://doi.org/10.1016/j.expneurol.2005.07.013
Dendrimers are important molecules that are currently undergoing investigation for use in a variety of different biomedical applications. This book explores the use of dendrimers for a variety of potential functions, including antiamyloidogenic agent
Publikováno v:
British journal of pharmacology. 172(11)
Hypoxia inducible factor-1 (HIF-1) promotes transitory neuronal survival suggesting that additional mechanisms such as the endoplasmic reticulum (ER) stress might be involved in determining neuronal survival or death. Here, we examined the involvemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30c3a8bbbc0a201ccfdb69985a622a5a
https://pubmed.ncbi.nlm.nih.gov/25625917
https://pubmed.ncbi.nlm.nih.gov/25625917