Výsledky vyhledávání - "Valentin Ceña"

Akademický článek

Evaluation of Amino-Functional Polyester Dendrimers Based on Bis-MPA as Nonviral Vectors for siRNA Delivery

Autor: Patrik Stenström, Dario Manzanares, Yuning Zhang, Valentin Ceña, Michael Malkoch

Publikováno v: Molecules, Vol 23, Iss 8, p 2028 (2018)

Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation o

Externí odkaz: https://doaj.org/article/a54250abce134adc82e51327bebccd88

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Exploration of biomedical dendrimer space based on in-vivo physicochemical parameters: Key factor analysis (Part 2)

Autor: Serge Mignani, João Rodrigues, René Roy, Xiangyang Shi, Valentin Ceña, Saïd El Kazzouli, Jean-Pierre Majoral

Publikováno v: Drug Discovery Today Biosilico
Drug Discovery Today Biosilico, 2019, 24 (5), pp.1184-1192. ⟨10.1016/j.drudis.2019.03.001⟩
Drug Discovery Today Biosilico, Elsevier, 2019, 24 (5), pp.1184-1192. ⟨10.1016/j.drudis.2019.03.001⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

International audience; In nanomedicine, the widespread concern of nanoparticles in general, and dendrimers, in particular, is the analysis of key in-vivo physicochemical parameters to ensure the preclinical and clinical development of ‘safe’ bio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ba393238c708a39984b82cfa4fd9bdd
https://doi.org/10.1016/j.drudis.2019.03.001

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LRRK2 and Proteostasis in Parkinson’s Disease

Autor: Valentin Ceña, María Dolores Perez Carrión, José Javier Solera Santos, Inmaculada Posadas

Publikováno v: International Journal of Molecular Sciences. 23:6808

Parkinson’s disease is a neurodegenerative condition initially characterized by the presence of tremor, muscle stiffness and impaired balance, with the deposition of insoluble protein aggregates in Lewy’s Bodies the histopathological hallmark of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4973e2463e7c676eddebe498e59f32
https://doi.org/10.3390/ijms23126808

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Functionalized carbon nanotubes in the brain: cellular internalization and neuroinflammatory responses

Autor: Valentin, Ceña, Giuseppe, Bardi, Antonio, Nunes, Lisa, Gherardini, Katie, Bates, Al Jamal, Khuloud T., Claire, Gaillard, Prato, Maurizio, Alberto, Bianco, Tommaso, Pizzorusso, Kostas, Kostarelos

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80964 (2013)
PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (11), pp.e80964. ⟨10.1371/journal.pone.0080964⟩

The potential use of functionalized carbon nanotubes (f-CNTs) for drug and gene delivery to the central nervous system (CNS) and as neural substrates makes the understanding of their in vivo interactions with the neural tissue essential. The aim of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2ad7fa4292a9c2ebb8e6dfdf5ce861
http://europepmc.org/articles/PMC3832421?pdf=render

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Cholinergic modulation of status epilepticus in the rat barrel field region of primary somatosensory cortex

Autor: Valentin Ceña, Miguel A Pozo, Eduardo D. Martín

Publikováno v: Experimental Neurology. 196:120-125

Status epilepticus (SE) represents a serious medical emergency that can produce long-lasting brain damage as well as cognitive and memory deficits. However, the mechanisms that determine the emergence of SE from a single seizure and the prolonged dur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722defd6d5a65d48a6c828ae19df26e2
https://doi.org/10.1016/j.expneurol.2005.07.013

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Elektronická kniha

Dendrimers in Biomedical Applications

Autor: Barbara Klajnert, Ling Peng, Valentin Cena

Dendrimers are important molecules that are currently undergoing investigation for use in a variety of different biomedical applications. This book explores the use of dendrimers for a variety of potential functions, including antiamyloidogenic agent

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The endoplasmic reticulum stress and the HIF-1 signalling pathways are involved in the neuronal damage caused by chemical hypoxia

Autor: Beatriz, López-Hernández, Valentin, Ceña, Inmaculada, Posadas

Publikováno v: British journal of pharmacology. 172(11)

Hypoxia inducible factor-1 (HIF-1) promotes transitory neuronal survival suggesting that additional mechanisms such as the endoplasmic reticulum (ER) stress might be involved in determining neuronal survival or death. Here, we examined the involvemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30c3a8bbbc0a201ccfdb69985a622a5a
https://pubmed.ncbi.nlm.nih.gov/25625917

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