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Complex approach for analysis of snake venom α-neurotoxins binding to HAP, the high-affinity peptide
Autor:
Gleb S. Budylin, Natalia S. Egorova, Elena V. Kryukova, Artjom V. Jegorov, Valentin М. Tabakmakher, Roman G. Efremov, Igor E. Kasheverov, Svetlana Yu. Belukhina, Igor Ivanov, Irina V. Shelukhina, Evgeny A. Shirshin, Maxim N. Zhmak, Denis S. Kudryavtsev, Victor I. Tsetlin, Nadezhda G. Zhdanova
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Snake venom α-neurotoxins, invaluable pharmacological tools, bind with high affinity to distinct subtypes of nicotinic acetylcholine receptor. The combinatorial high-affinity peptide (HAP), homologous to the C-loop of α1 and α7 nAChR subunits, bin