Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Valentia M. Lee"'
Autor:
Dittakavi S. R. Sarma, James E. Korkola, Geoffrey A. Wood, Valentia M. Lee, Michael C. Archer
Publikováno v:
Carcinogenesis. 18:1745-1750
Copenhagen (Cop) rats are completely resistant to the chemical induction of mammary adenocarcinomas, but their susceptibility to hepatocarcinogenesis is virtually unknown. Rat liver is a well-characterized and easily manipulated tissue in which to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ade968f7eac3134d3336c0a9f2a4a9
https://doi.org/10.1093/carcin/18.9.1745
https://doi.org/10.1093/carcin/18.9.1745
Publikováno v:
Chemical Research in Toxicology. 9:1319-1324
N-Nitrosodimethylamine (NDMA) is a potent hepatotoxic agent in rats. NDMA causes cell death that does not correlate with known mechanisms of toxicity such as the production of oxidative stress or covalent binding to proteins. The following studies we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc8c174f129af93f04ea48d28d0159e
https://doi.org/10.1021/tx960077u
https://doi.org/10.1021/tx960077u
Publikováno v:
Chemical Research in Toxicology. 6:372-375
N-Nitrosodimethylamine (NDMA) is a potent hepatotoxicant in the rat, but the mechanism by which it lethally injures hepatocytes is not known. NDMA is metabolized in the liver to the methanediazonium ion that methylates hepatic DNA. Neither N-nitrosom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a0cd802459aa6b7b05fa027ce9e29f
https://doi.org/10.1021/tx00033a019
https://doi.org/10.1021/tx00033a019
Publikováno v:
Carcinogenesis. 14:1403-1408
N-Nitrosodimethylamine (NDMA) is a carcinogen in rat liver while N-nitrosomethylbenzylamine (NMBzA) produces no liver tumors but is a potent esophageal carcinogen in the rat. Both nitrosamines, however, are metabolically activated in the liver and me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416b7f8941d7e93633a57f6c3381f284
https://doi.org/10.1093/carcin/14.7.1403
https://doi.org/10.1093/carcin/14.7.1403
Publikováno v:
ACS Symposium Series ISBN: 0841228566
Nitrosamines and RelatedN-Nitroso Compounds: Chemistry and Biochemistry
Nitrosamines and RelatedN-Nitroso Compounds: Chemistry and Biochemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::650d5ee0bc7b412ec45444284780c5e7
https://doi.org/10.1021/bk-1994-0553.ch022
https://doi.org/10.1021/bk-1994-0553.ch022
