Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Valentín Iglesias"'
Autor:
Javier Garcia-Pardo, Aleksandra E. Badaczewska-Dawid, Carlos Pintado-Grima, Valentín Iglesias, Aleksander Kuriata, Sebastian Kmiecik, Salvador Ventura
Publikováno v:
Microbial Cell Factories, Vol 22, Iss 1, Pp 1-10 (2023)
Abstract Background The budding yeast Saccharomyces cerevisiae (S. cerevisiae) is a well-established model system for studying protein aggregation due to the conservation of essential cellular structures and pathways found across eukaryotes. However,
Externí odkaz:
https://doaj.org/article/85f3760bcf784292a615fc060c301274
Autor:
Carlos Pintado-Grima, Oriol Bárcenas, Andrea Bartolomé-Nafría, Marc Fornt-Suñé, Valentín Iglesias, Javier Garcia-Pardo, Salvador Ventura
Publikováno v:
Biophysica, Vol 3, Iss 1, Pp 1-20 (2023)
The presence of insoluble protein deposits in tissues and organs is a hallmark of many human pathologies. In addition, the formation of protein aggregates is considered one of the main bottlenecks to producing protein-based therapeutics. Thus, there
Externí odkaz:
https://doaj.org/article/1f94c3e420fa44458982adf40c6c7cd0
Autor:
Carlos Pintado-Grima, Jaime Santos, Valentín Iglesias, Zoe Manglano-Artuñedo, Irantzu Pallarès, Salvador Ventura
Publikováno v:
Frontiers in Plant Science, Vol 13 (2023)
Prion-like domains (PrLDs) are intrinsically disordered regions (IDRs) of low sequence complexity with a similar composition to yeast prion domains. PrLDs-containing proteins have been involved in different organisms’ regulatory processes. Regions
Externí odkaz:
https://doaj.org/article/15657a46eaa94e05bef086f68174c190
Publikováno v:
FEBS Open Bio, Vol 11, Iss 9, Pp 2400-2417 (2021)
Prions are self‐perpetuating proteins able to switch between a soluble state and an aggregated‐and‐transmissible conformation. These proteinaceous entities have been widely studied in yeast, where they are involved in hereditable phenotypic ada
Externí odkaz:
https://doaj.org/article/5c6db728f9a3467c98665ecb3000f21f
Cryptic amyloidogenic regions in intrinsically disordered proteins: Function and disease association
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4192-4206 (2021)
The amyloid conformation is considered a fundamental state of proteins and the propensity to populate it a generic property of polypeptides. Multiple proteome-wide analyses addressed the presence of amyloidogenic regions in proteins, nurturing our un
Externí odkaz:
https://doaj.org/article/1b52041efa614ed795d10b029b3ec050
Autor:
Sonia Alfonso, António M. Diniz, Manuel Deaño, Fernando Tellado, Mar García-Señorán, Ángeles Conde, Valentín Iglesias-Sarmiento
Publikováno v:
Psicologia: Reflexão e Crítica, Vol 33, Iss 1, Pp 1-9 (2020)
Abstract We examined the relationships among gender, planning, and academic expectations through the testing of two alternative models with latent variables tested with LISREL 8.80: one model considered planning as a mediator of the relationship betw
Externí odkaz:
https://doaj.org/article/2c458e8f12ab46a9bb8a6a3c436d1f77
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 1403-1413 (2020)
Protein aggregation is a widespread phenomenon that stems from the establishment of non-native intermolecular contacts resulting in protein precipitation. Despite its deleterious impact on fitness, protein aggregation is a generic property of polypep
Externí odkaz:
https://doaj.org/article/fef7fcb29f5640b892883226fc0c8f72
Publikováno v:
INFAD, Vol 2, Iss 2 (2021)
Este estudio analizó la comprensión conceptual aritmética desde una doble vía, (conceptual y estratégica) del alumnado escolarizado en 4º, 5º y 6º de Educación Primaria, seleccionado en base a tres grupos de logro: dificultades de aprendizaj
Externí odkaz:
https://doaj.org/article/9dabf42271804493ac17e83228d89b76
Autor:
Carlota Roca, Yunuen Avalos-Padilla, Beatriz Prieto-Simón, Valentín Iglesias, Miriam Ramírez, Santiago Imperial, Xavier Fernàndez-Busquets
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2515 (2022)
The methyl erythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential for malaria parasites and also for several human pathogenic bacteria, thus representing an interesting target for future antimalarials and antibiotics and for diagn
Externí odkaz:
https://doaj.org/article/5df771176394415fbdf913a9d7b24752
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Proteins bearing prion-like domains (PrLDs) are essential players in stress granules (SG) assembly. Analysis of data on heat stress-induced recruitment of yeast PrLDs to SG suggests that this propensity might be connected with three defined protein b
Externí odkaz:
https://doaj.org/article/22e9497396824d20990dea0b9776c28d