Senescent stroma induces nuclear deformations in cancer cells via the inhibition of RhoA/ROCK/myosin II-based cytoskeletal tension.

Autor: Aifuwa I; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Kim BC; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Division of Nano-Bioengineering, Incheon National University, Incheon 22012, South Korea., Kamat P; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Starich B; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Agrawal A; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Tanrioven D; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA., Luperchio TR; Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA., Valencia AMJ; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Perestrelo T; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA., Reddy K; Department of Biological Chemistry, Johns Hopkins University, Baltimore, MD 21218, USA., Ha T; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biophysics and Biophysical Chemistry, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.; Howard Hughes Medical Institute, Baltimore, MD 21205, USA., Philip JM; Johns Hopkins Physical Sciences - Oncology Center, Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.; Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

Publikováno v: PNAS nexus [PNAS Nexus] 2022 Dec 06; Vol. 2 (1), pp. pgac270. Date of Electronic Publication: 2022 Dec 06 (Print Publication: 2023).