Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Valdemaras Petrosius"'
Autor:
Valdemaras Petrosius, Pedro Aragon-Fernandez, Nil Üresin, Gergo Kovacs, Teeradon Phlairaharn, Benjamin Furtwängler, Jeff Op De Beeck, Sarah L. Skovbakke, Steffen Goletz, Simon Francis Thomsen, Ulrich auf dem Keller, Kedar N. Natarajan, Bo T. Porse, Erwin M. Schoof
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Single-cell resolution analysis of complex biological tissues is fundamental to capture cell-state heterogeneity and distinct cellular signaling patterns that remain obscured with population-based techniques. The limited amount of material e
Externí odkaz:
https://doaj.org/article/14054e0093804c9391743fbe1ba55ea0
Autor:
Youngho Kwon, Heike Rösner, Weixing Zhao, Platon Selemenakis, Zhuoling He, Ajinkya S. Kawale, Jeffrey N. Katz, Cody M. Rogers, Francisco E. Neal, Aida Badamchi Shabestari, Valdemaras Petrosius, Akhilesh K. Singh, Marina Z. Joel, Lucy Lu, Stephen P. Holloway, Sandeep Burma, Bipasha Mukherjee, Robert Hromas, Alexander Mazin, Claudia Wiese, Claus S. Sørensen, Patrick Sung
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Exon 27 of the tumor suppressor BRCA2 encodes a portion of the protein crucial for DNA repair, genome maintenance, and tumor suppression. Here the authors show that this domain binds DNA and the RAD51 recombinase to enhance the assembly of RAD51-DNA
Externí odkaz:
https://doaj.org/article/31023ba9447a4531befe74ed9fc6d0e3
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105806- (2023)
Summary: Wee1-like protein kinase (WEE1) restrains activities of cyclin-dependent kinases (CDKs) in S and G2 phase. Inhibition of WEE1 evokes drastic increase in CDK activity, which perturbs replication dynamics and compromises cell cycle checkpoints
Externí odkaz:
https://doaj.org/article/37a3c2b431144addafffad64e750b3d8
Autor:
Valdemaras Petrosius, Erwin M. Schoof
Publikováno v:
Translational Oncology, Vol 27, Iss , Pp 101556- (2023)
The field of single-cell omics is rapidly progressing. Although DNA and RNA sequencing-based methods have dominated the field to date, global proteome profiling has also entered the main stage. Single-cell proteomics was facilitated by advancements i
Externí odkaz:
https://doaj.org/article/27cc4e9753ae47f09f09a778521f5dbf
Autor:
Teeradon Phlairaharn, Samuel Grégoire, Lukas R. Woltereck, Valdemaras Petrosius, Benjamin Furtwängler, Brian C. Searle, Erwin M. Schoof
Publikováno v:
Phlairaharn, T, Grégoire, S, Woltereck, L R, Petrosius, V, Furtwängler, B, Searle, B C & Schoof, E M 2022, ' High Sensitivity Limited Material Proteomics Empowered by Data-Independent Acquisition on Linear Ion Traps ', Journal of Proteome Research, vol. 21, no. 11, pp. 2815-2826 . https://doi.org/10.1021/acs.jproteome.2c00376
In recent years, the concept of cell heterogeneity in biology has gained increasing attention, concomitant with a push towards technologies capable of resolving such biological complexity at the molecular level. For single-cell proteomics using Mass
Autor:
Jan Benada, Daria Bulanova, Violette Azzoni, Valdemaras Petrosius, Saba Ghazanfar, Krister Wennerberg, Claus Storgaard Sørensen
Publikováno v:
Benada, J, Bulanova, D, Azzoni, V, Petrosius, V, Ghazanfar, S, Wennerberg, K & Sørensen, C S 2023, ' Synthetic lethal interaction between WEE1 and PKMYT1 is a target for multiple low-dose treatment of high-grade serous ovarian carcinoma ', Nar Cancer, vol. 5, no. 3, zcad029 . https://doi.org/10.1093/narcan/zcad029
Ovarian cancer is driven by genetic alterations that necessitate protective DNA damage and replication stress responses through cell cycle control and genome maintenance. This creates specific vulnerabilities that may be exploited therapeutically. WE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c14342fd55f305f7b41241975e74b9b
https://orbit.dtu.dk/en/publications/e56196eb-391b-4150-9466-9d9b8439727f
https://orbit.dtu.dk/en/publications/e56196eb-391b-4150-9466-9d9b8439727f
Autor:
Valdemaras Petrosius, Pedro Aragon-Fernandez, Nil Üresin, Teeradon Phlairaharn, Benjamin Furtwängler, Jeff op de Beeck, Simon Francis Thomsen, Ulrich auf dem Keller, Bo T. Porse, Erwin M. Schoof
Single-cell resolution analysis of complex biological tissues is fundamental to capture cell-state heterogeneity and distinct cellular signaling patterns that remain obscured with population-based techniques. The limited amount of material encapsulat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7dee1a7259d124de75c15e8612f834c
https://doi.org/10.1101/2022.11.29.518366
https://doi.org/10.1101/2022.11.29.518366
Contains QIBC data and analysis code for the publication
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367afa134f1fd08f79f849105d914a6f
Publikováno v:
Petrosius, V & Schoof, E M 2023, ' Recent advances in the field of single-cell proteomics ', Translational Oncology, vol. 27, 101556 . https://doi.org/10.1016/j.tranon.2022.101556
The field of single-cell omics is rapidly progressing. Although DNA and RNA sequencing-based methods have dominated the field to date, global proteome profiling has also entered the main stage. Single-cell proteomics was facilitated by advancements i
Autor:
Camilla Reiter Elbæk, Valdemaras Petrosius, Jan Benada, Louisa Erichsen, Rune Busk Damgaard, Claus Storgaard Sørensen
Publikováno v:
Elbæk, C R, Petrosius, V, Benada, J, Erichsen, L, Damgaard, R B & Sørensen, C S 2022, ' WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity ', Cell Reports, vol. 38, no. 3, 110261 . https://doi.org/10.1016/j.celrep.2021.110261
Cellular feedback systems ensure genome maintenance during DNA replication. When replication forks stall, newly replicated DNA is protected by pathways that limit excessive DNA nuclease attacks. Here we show that WEE1 activity guards against nascent