Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Valdeci da Cunha"'
Autor:
Valdeci da Cunha, Baby Martin-McNulty, Jon Vincelette, Lening Zhang, John C. Rutledge, Dennis W. Wilson, Ronald Vergona, Mark E. Sullivan, Yi-Xin Wang
Publikováno v:
Journal of Lipid Research, Vol 47, Iss 3, Pp 476-483 (2006)
Two month old C57BL/6 mice were placed on three different diets: 1) normal diet (NC; 0.025% cholesterol), 2) hypercholesterolemic Western-type diet (HC-W; 0.2% cholesterol), and 3) hypercholesterolemic Paigen-type diet (HC-P; 1.25% cholesterol plus 0
Externí odkaz:
https://doaj.org/article/e227057925374cc8a8394b43c49c1e84
Autor:
Valdeci Da Cunha, Anju Balakrishnan, David E. Gutstein, Jessica J. Moorleghen, Hong Lu, Douglas G. Johns, Alan Daugherty, Debra L. Rateri, Xiaojie Xie, Deborah A. Howatt, Maya Dajee
Publikováno v:
Circulation journal : official journal of the Japanese Circulation Society. 81(6)
Background This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA).Methods and Results:Male C57BL/6 or apolipoprotein E-/-mice were infused with AngII with o
Autor:
Valdeci Da Cunha, Kersten M. Small, Shu-Yu Sun, Xiaoli Ping, Liming Yang, Xiaolan Shen, Barry R. Campbell, Shuqin Zheng, Xuening Hong, Huawei Zhao, Chin-hu Huang, Richard Kennan, Jeffrey Madwed
Publikováno v:
Circulation Research. 119
The absence of animal models displaying clinical phenotypes of HFpEF represents a challenge to the pharmaceutical industry in the hope of identifying novel treatments that would benefit patients with this syndrome. We, at Merck, examined the supracor
Autor:
Maya Dajee, Jessica J. Moorleghen, Hong Lu, Valdeci Da Cunha, Michael W. Seganish, Anju Balakrishnan, Douglas G. Johns, Deborah A. Howatt
Publikováno v:
Circulation Research. 119
Introduction: Human relaxin is being tested clinically as an acute treatment for heart failure. The effects of relaxin on extracellular matrix remodeling, among several mechanisms, may provide myocardial benefit, however, the effects of relaxin on va
Autor:
Sharlene Velichko, Yi-Xin Wang, Yifan Xu, Brent Larsen, Cynthia Gross, Richard M. Fitch, Mark E. Sullivan, Jon Vincelette, Valdeci da Cunha, Kirk U. Knowlton, Ronald Vergona, Toshitaka Yajima, Ed Croze, Kathy White, Meredith Halks-Miller
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H69-H76
The present study tested the hypothesis that murine (m)IFN-β or mIFN-α2can eliminate cardiac viral load and protect cardiomyocytes from injury in animals infected with coxsackievirus B3 (CVB3). CVB3-inoculated male Balb/c mice exhibited signs of il
Autor:
Mariko Nagashima, Kumar Emayan, Imadul Islam, William P. Dole, Lei Zhao, Shendong Yuan, Yi-Xin Wang, Ronald Vergona, Kohichi Kawai, Mark E. Sullivan, Brad O. Buckman, John Morser, Junko Hosoya, Jon Vincelette, Valdeci da Cunha
Publikováno v:
Thrombosis and Haemostasis. 97:54-61
SummaryWe have discovered a novel small-molecule TAFIa inhibitor, BX 528, which is potent, highly selective against other carboxypeptidases and safe. The present study was to determine if BX 528 can enhance exogenous and endogenous thrombolysis in fo
Autor:
Dennis W Wilson, Miriam Schroeder, Yi-Xin Jim Wang, David F. Choy, Ronald Vergona, Valdeci da Cunha, Baby Martin-McNulty, Jon Vincelette, Mithra Mahmoudi, Mark E. Sullivan, Meredith Halks-Miller, We-Wei Li
Publikováno v:
Journal of Vascular Surgery. 44:364-371
BackgroundWe explored the role of angiotensin II in determining the histomorphometric features of plaque stability in apolipoprotein E–deficient mice submitted to ligation of the carotid artery.MethodsSix-month-old apolipoprotein E–deficient mice
Publikováno v:
Basic Toxicology. 97:29-34
L-NAME-induced hypertension is characterized by chronic inhibition of nitric oxide synthesis. We have investigated if tempol, an agent mimicking superoxide dismutase might reduce hypertension and the increased vascular reactivity to pressor agents. R
Autor:
Weiwei Li, Yi-Xin Wang, Anthony Johns, Mithra Mahmoudi, Baby Martin-McNulty, Valdeci da Cunha, William P. Dole, Meredith Halks-Miller, Jon Vincelette, David F. Choy, Miriam Schroeder, David R. Light
Publikováno v:
European Journal of Pharmacology. 512:215-222
Recent evidence indicates that the GTPase activated Rho/Rho-kinase pathway contributes angiotensin II-induced cardiac hypertrophy and vascular remodeling. We tested this hypothesis in vivo by determining the effects of fasudil, a Rho-kinase inhibitor
Autor:
Dennis W Wilson, Yi-Xin Jim Wang, Baby Martin-McNulty, Gary Deng, John C. Rutledge, Jerrick J. Ho, Mark E. Sullivan, Doris M. Tham, Ronald Vergona, Valdeci da Cunha
Publikováno v:
Atherosclerosis. 178:9-17
Angiotensin converting enzyme (ACE) inhibitors prevent a wide variety of key events underlying atherogenesis. Whether these actions depend solely on reduction of angiotensin II (Ang II) generation is still to be determined. This study was undertaken