Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis.

Autor: Ardanaz CG; Department of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain., de la Cruz A; Laboratory of Local Translation in Neurons and Glia, Achucarro Basque Centre for Neuroscience, 48940 Leioa, Spain., Minhas PS; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Hernández-Martín N; Unidad de Cartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, Spain.; PET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA., Pozo MÁ; Unidad de Cartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense de Madrid, 28040 Madrid, Spain.; Unidad de Cartografía Cerebral, Instituto de Investigación Sanitaria, Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.; Departamento de Fisiología, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain., Valdecantos MP; Instituto de Investigaciones Biomédicas Sols-Morreale, CSIC-UAM, Department of Metabolism and Cellular Signaling, Madrid 28029, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Madrid 28029, Spain.; Universidad Francisco de Vitoria, Faculty of Experimental Sciences, Pozuelo de Alarcon, Madrid, Spain., Valverde ÁM; Instituto de Investigaciones Biomédicas Sols-Morreale, CSIC-UAM, Department of Metabolism and Cellular Signaling, Madrid 28029, Spain.; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Madrid 28029, Spain., Villa-Valverde P; ICTS Bioimagen Complutense, Universidad Complutense de Madrid, Madrid, Spain., Elizalde-Horcada M; Institut d'Investigació Sanitaria Pere Virgili (IISPV), 43204 Reus, Spain., Puerta E; Department of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain., Ramírez MJ; Department of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain., Ortega JE; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Spain.; Department of Pharmacology, University of the Basque Country (UPV/EHU), 48940 Leioa, Spain.; Biobizkaia Health Research Institute, 48903 Barakaldo, Spain., Urbiola A; IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.; Imaging Platform, Foundation for Applied Medical Research (FIMA), University of Navarra (UNAV), 31008 Pamplona, Spain., Ederra C; IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.; Imaging Platform, Foundation for Applied Medical Research (FIMA), University of Navarra (UNAV), 31008 Pamplona, Spain., Ariz M; IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.; Imaging Platform, Foundation for Applied Medical Research (FIMA), University of Navarra (UNAV), 31008 Pamplona, Spain.; Department of Electrical, Electronic and Communications Engineering, Public University of Navarra, 31006 Pamplona, Spain., Ortiz-de-Solórzano C; IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.; Imaging Platform, Foundation for Applied Medical Research (FIMA), University of Navarra (UNAV), 31008 Pamplona, Spain., Fernández-Irigoyen J; Proteomics Platform, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, 31008 Pamplona, Spain., Santamaría E; Clinical Neuroproteomics Unit, Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Pública de Navarra (UPNA), IdiSNA, 31008 Pamplona, Spain., Karsenty G; Department of Genetics and Development, Vagelos College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY, USA., Brüning JC; Max Planck Institute for Metabolism Research, Department of Neuronal Control of Metabolism, 50931 Cologne, Germany.; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP), University Hospital Cologne, 50924 Cologne, Germany.; Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (CECAD) and Center of Molecular Medicine Cologne (CMMC), University of Cologne, 50931 Cologne, Germany.; National Center for Diabetes Research (DZD), 85764 Neuherberg, Germany., Solas M; Department of Pharmaceutical Sciences, Division of Pharmacology, University of Navarra, 31008 Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, 31008 Pamplona, Spain.

Publikováno v: Science advances [Sci Adv] 2024 Oct 18; Vol. 10 (42), pp. eadp1115. Date of Electronic Publication: 2024 Oct 18.

Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC-induced cholestatic injury by promoting a pro-restorative inflammatory response.

Autor: Lazcanoiturburu N; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the 'Hospital Clínico San Carlos' (IdISSC), Madrid, Spain., García-Sáez J; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the 'Hospital Clínico San Carlos' (IdISSC), Madrid, Spain., González-Corralejo C; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the 'Hospital Clínico San Carlos' (IdISSC), Madrid, Spain., Roncero C; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the 'Hospital Clínico San Carlos' (IdISSC), Madrid, Spain., Sanz J; Anatomical Pathology Service of the 'Clínica Universidad de Navarra', Madrid, Spain.; Department of Psychiatry, Legal Medicine and Anatomical Pathology, Faculty of Medicine, UCM, Madrid, Spain., Martín-Rodríguez C; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the 'Hospital Clínico San Carlos' (IdISSC), Madrid, Spain., Valdecantos MP; 'Alberto Sols' Biomedical Research Institute, Spanish National Research Council and Autonomous University of Madrid (IIBM, CSIC-UAM), Madrid, Spain.; Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders of the Carlos III Health Institute (CIBERDEM-ISCIII), Madrid, Spain., Martínez-Palacián A; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the 'Hospital Clínico San Carlos' (IdISSC), Madrid, Spain., Almalé L; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the 'Hospital Clínico San Carlos' (IdISSC), Madrid, Spain., Bragado P; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the 'Hospital Clínico San Carlos' (IdISSC), Madrid, Spain., Calero-Pérez S; 'Alberto Sols' Biomedical Research Institute, Spanish National Research Council and Autonomous University of Madrid (IIBM, CSIC-UAM), Madrid, Spain.; Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders of the Carlos III Health Institute (CIBERDEM-ISCIII), Madrid, Spain., Fernández A; National Center for Biotechnology (CNB-CSIC), Biomedical Research Networking Center on Rare Diseases (CIBERER-ISCIII), Madrid, Spain., García-Bravo M; Cell Technology Division, Research Center for Energy, Environment and Technology (CIEMAT), Biomedical Research Networking Center on Rare Diseases (CIBERER-ISCIII), Madrid, Spain.; Advanced Therapies Mixed Unit, 'Fundación Jiménez Díaz' University Hospital Health Research Institute (CIEMAT/IIS-FJD), Madrid, Spain., Guerra C; Molecular Oncology Programme, Spanish National Cancer Research Center (CNIO), Madrid, Spain., Montoliu L; National Center for Biotechnology (CNB-CSIC), Biomedical Research Networking Center on Rare Diseases (CIBERER-ISCIII), Madrid, Spain., Segovia JC; Cell Technology Division, Research Center for Energy, Environment and Technology (CIEMAT), Biomedical Research Networking Center on Rare Diseases (CIBERER-ISCIII), Madrid, Spain.; Advanced Therapies Mixed Unit, 'Fundación Jiménez Díaz' University Hospital Health Research Institute (CIEMAT/IIS-FJD), Madrid, Spain., Valverde ÁM; 'Alberto Sols' Biomedical Research Institute, Spanish National Research Council and Autonomous University of Madrid (IIBM, CSIC-UAM), Madrid, Spain.; Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders of the Carlos III Health Institute (CIBERDEM-ISCIII), Madrid, Spain., Fabregat I; TGF-β and Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain.; Oncology Program, Biomedical Research Networking Center in Hepatic and Digestive Diseases (CIBEREHD-ISCIII), Madrid, Spain.; Department of Physiological Sciences, Faculty of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Spain., Herrera B; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the 'Hospital Clínico San Carlos' (IdISSC), Madrid, Spain., Sánchez A; Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, Complutense University of Madrid (UCM), Health Research Institute of the 'Hospital Clínico San Carlos' (IdISSC), Madrid, Spain.

Publikováno v: The Journal of pathology [J Pathol] 2022 Nov; Vol. 258 (3), pp. 312-324. Date of Electronic Publication: 2022 Sep 23.

Metabolic impact of partial hepatectomy in the non-alcoholic steatohepatitis animal model of methionine-choline deficient diet.

Autor: Carril E; CEMBIO, Centre for Metabolomics and Bioanalysis, Facultad de Farmacia, Universidad San Pablo CEU, Madrid, Spain., Valdecantos MP; Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM), Madrid, Spain; Centro de investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Madrid, Spain., Lanzón B; CEMBIO, Centre for Metabolomics and Bioanalysis, Facultad de Farmacia, Universidad San Pablo CEU, Madrid, Spain; Facultad de CC. de la Salud, Universidad Rey Juan Carlos, Spain., Angulo S; CEMBIO, Centre for Metabolomics and Bioanalysis, Facultad de Farmacia, Universidad San Pablo CEU, Madrid, Spain., Valverde ÁM; Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM), Madrid, Spain; Centro de investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), ISCIII, Madrid, Spain., Godzien J; CEMBIO, Centre for Metabolomics and Bioanalysis, Facultad de Farmacia, Universidad San Pablo CEU, Madrid, Spain; Clinical research Centre, Medical university of Bialystok, Bialystok, Poland., Rupérez FJ; CEMBIO, Centre for Metabolomics and Bioanalysis, Facultad de Farmacia, Universidad San Pablo CEU, Madrid, Spain. Electronic address: ruperez@ceu.es.

Publikováno v: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2020 Jan 30; Vol. 178, pp. 112958. Date of Electronic Publication: 2019 Nov 01.

Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases.

Autor: García-Ruiz I; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029, Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain; Laboratorio de Gastroenterología y Hepatología, Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, 28041, Madrid, Spain. Electronic address: inmagr86@hotmail.com., Blanes Ruiz N; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029, Madrid, Spain., Rada P; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029, Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain., Pardo V; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029, Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain., Ruiz L; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029, Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain., Blas-García A; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERhed), ISCIII, 28029, Madrid, Spain; Departamento de Farmacología, Facultad de Medicina, Universitat de València, Valencia, Spain., Valdecantos MP; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029, Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain., Grau Sanz M; Laboratorio de Gastroenterología y Hepatología, Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, 28041, Madrid, Spain., Solís Herruzo JA; Laboratorio de Gastroenterología y Hepatología, Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, 28041, Madrid, Spain., Valverde ÁM; Instituto de Investigaciones Biomédicas Alberto Sols (CSIC-UAM), 28029, Madrid, Spain; Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), ISCIII, 28029, Madrid, Spain. Electronic address: avalverde@iib.uam.es.

Publikováno v: Redox biology [Redox Biol] 2019 Sep; Vol. 26, pp. 101263. Date of Electronic Publication: 2019 Jun 29.

SIRT1 Controls Acetaminophen Hepatotoxicity by Modulating Inflammation and Oxidative Stress.

Autor: Rada P; 1 Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM) , Madrid, Spain .; 2 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III , Madrid, Spain ., Pardo V; 1 Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM) , Madrid, Spain .; 2 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III , Madrid, Spain ., Mobasher MA; 1 Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM) , Madrid, Spain .; 2 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III , Madrid, Spain .; 3 Division of Biochemistry, Department of Pathology, College of Medicine, Al Jouf University , Sakaka, Saudi Arabia ., García-Martínez I; 1 Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM) , Madrid, Spain ., Ruiz L; 1 Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM) , Madrid, Spain .; 2 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III , Madrid, Spain ., González-Rodríguez Á; 4 Hospital Universitario Santa Cristina, Instituto de Investigación Sanitaria Princesa , Madrid, Spain ., Sanchez-Ramos C; 1 Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM) , Madrid, Spain ., Muntané J; 5 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Instituto de Salud Carlos III , Madrid, Spain .; 6 Oncology Surgery, Cell Therapy and Transplant Organs, Institute of Biomedicine of Seville (IBiS)/University Hospital Virgen del Rocio/CSIC/University of Seville , Seville, Spain ., Alemany S; 1 Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM) , Madrid, Spain ., James LP; 7 Section of Clinical Pharmacology and Toxicology, Arkansas Children's Hospital , Little Rock, Arkansas., Simpson KJ; 8 Division of Clinical and Surgical Sciences, University of Edinburgh , Edinburgh, United Kingdom ., Monsalve M; 1 Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM) , Madrid, Spain ., Valdecantos MP; 1 Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM) , Madrid, Spain .; 2 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III , Madrid, Spain ., Valverde ÁM; 1 Instituto de Investigaciones Biomédicas Alberto Sols (Centro Mixto CSIC-UAM) , Madrid, Spain .; 2 Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERdem), Instituto de Salud Carlos III , Madrid, Spain .

Publikováno v: Antioxidants & redox signaling [Antioxid Redox Signal] 2018 May 01; Vol. 28 (13), pp. 1187-1208. Date of Electronic Publication: 2017 Dec 11.