Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Valda K. Vinson"'
Autor:
Valda K. Vinson
Publikováno v:
Science Signaling. 7
Flaviviruses cause human diseases such as West Nile fever and dengue fever. The flavivirus nonstructural protein 1 (NS1) has multiple functions in flavivirus biology and is a target for vaccine development. Dimeric NS1 is essential for replication of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10700b759263263e9dfff95350ebad5c
https://doi.org/10.1126/scisignal.2005205
https://doi.org/10.1126/scisignal.2005205
Autor:
Valda K. Vinson
Publikováno v:
Science Signaling. 7
The structure of a human serotonin receptor was solved using a free-electron laser to analyze microcrystals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f347892918e0c0b35458261f7c582f0
https://doi.org/10.1126/scisignal.2005041
https://doi.org/10.1126/scisignal.2005041
Publikováno v:
Biochemistry. 37:10871-10880
Three methods, fluorescence anisotropy of rhodamine-labeled profilin, intrinsic fluorescence and nucleotide exchange, give the same affinity, Kd = 0.1 microM, for Acanthamoeba profilins binding amoeba actin monomers with bound Mg-ATP. Replacement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504890375136e00be4fdd811092445f3
https://doi.org/10.1021/bi980093l
https://doi.org/10.1021/bi980093l
Autor:
Valda K. Vinson
Publikováno v:
Science Signaling. 6
A method to monitor drug binding to proteins in cells may help in target validation and drug optimization.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1d88483b579c166f7c9d77926fa8bb0
https://doi.org/10.1126/scisignal.2004484
https://doi.org/10.1126/scisignal.2004484
Autor:
Valda K. Vinson
Publikováno v:
Science Signaling. 5
Wnt proteins activate the transmembrane receptor Frizzled (Fz) to initiate pathways central to vertebrate and invertebrate development. Wnts are palmitoylated, which has complicated structural and functional characterization. Janda et al . (see the P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::455b20ce31cbbecd24f73d87d0d6d4d2
https://doi.org/10.1126/scisignal.2003373
https://doi.org/10.1126/scisignal.2003373
Autor:
Valda K. Vinson
Publikováno v:
Science Signaling. 5
After DNA damage, pulses of p53 allow recovery, whereas sustained levels lead to senescence.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c1a763b696c9005c7bfde24fe4c66e
https://doi.org/10.1126/scisignal.2003310
https://doi.org/10.1126/scisignal.2003310
Autor:
Valda K. Vinson
Publikováno v:
Science Signaling. 5
The β-amyloid (Aβ) peptides associated with Alzheimer’s disease are generated by cleavage of the transmembrane C-terminal domain (C99) of the amyloid precursor protein by the enzyme γ-secretase. Barrett et al . used nuclear magnetic resonance (N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9337d8b3e5b7f3c0b5a336fb6dcaced7
https://doi.org/10.1126/scisignal.2003278
https://doi.org/10.1126/scisignal.2003278
Autor:
Valda K. Vinson
Publikováno v:
Science Signaling. 5
Voltage-sensing domains (VSDs) control the activity of voltage-gated ion channels to regulate the ion flow that underlies nerve conduction. Structural and biophysical studies have provided insight into voltage gating; however, understanding has been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a06678eee9d3043716ff0b1d2155445
https://doi.org/10.1126/scisignal.2003138
https://doi.org/10.1126/scisignal.2003138
Autor:
Valda K. Vinson
Publikováno v:
Science Signaling. 5
For neurotransmitters to be released from a neuron, a synaptic vesicle must fuse with the plasma membrane and form a fusion pore. Soluble N -ethylmaleimide–sensitive factor attachment protein receptor (SNARE) complexes are the core protein machiner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c15e5b1525f7664fb642f2212f3b7cef
https://doi.org/10.1126/scisignal.2003049
https://doi.org/10.1126/scisignal.2003049
Publikováno v:
FEBS Letters. 337:145-151
The multifunctional protein profilin is one of the most abundant proteins in the cytoplasm and is thought to regulate actin assembly and the phosphoinositide signaling pathway. Profilin binds to several different ligands including actin, poly-l-proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a08d55d25e0b3a5949c2ce60dbb4415f
https://doi.org/10.1016/0014-5793(94)80262-9
https://doi.org/10.1016/0014-5793(94)80262-9