Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Valbona Luga"'
Autor:
Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan Earlie, Bobak Parang, Kripa Shobana Ganesh, Sungyun Cho, Jennifer Endress, Tanya Schild, Mengying Hu, David Lyden, Wenbing Jin, Chunjun Guo, Noah Dephoure, Lewis C. Cantley, Ashley M. Laughney, John Blenis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Methylmalonic acid (MMA) is increased in aging as well as produced by advanced tumors, and can drive pro-aggressive changes in these tumor cells. Here, the authors show that MMA can also act on fibroblasts in the tumor microenvironment, recruiting an
Externí odkaz:
https://doaj.org/article/f478066cc8a441dda1055be79d728377
Autor:
Nardos G. Tassew, Jason Charish, Alireza P. Shabanzadeh, Valbona Luga, Hidekiyo Harada, Nahal Farhani, Philippe D’Onofrio, Brian Choi, Ahmad Ellabban, Philip E.B. Nickerson, Valerie A. Wallace, Paulo D. Koeberle, Jeffrey L. Wrana, Philippe P. Monnier
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 99-111 (2017)
Developing strategies that promote axonal regeneration within the injured CNS is a major therapeutic challenge, as axonal outgrowth is potently inhibited by myelin and the glial scar. Although regeneration can be achieved using the genetic deletion o
Externí odkaz:
https://doaj.org/article/bea754c088164e87b4812073230a8838
Autor:
Liang Zhang, Valbona Luga, Sarah K. Armitage, Martin Musiol, Amy Won, Christopher M. Yip, Sergey V. Plotnikov, Jeffrey L. Wrana
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Migrating cells display dynamic morphologies that are coordinated by signalling pathways. Here the authors identify a lateral signalling pathway, comprised of the planar cell polarity protein Pk1 and Arhgap21/23, that regulates fluctuations in cell s
Externí odkaz:
https://doaj.org/article/b635d2a26aed42ca9f20cdfb111a9045
Autor:
Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan Earlie, Bobak Parang, Kripa Shobana Ganesh, Sungyun Cho, Jennifer Endress, Tanya Schild, Menying Hu, David Lyden, Wenbing Jin, Chun-Jun Guo, Noah Dephoure, Lewis Cantley, Ashley Laughney, John Blenis
The systemic metabolic shifts that occur during aging and the local metabolic alterations of a tumor, its stroma and their communication cooperate to establish a unique tumor microenvironment (TME) that fosters cancer progression. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9575aa72d5bb5e58a9b27e65aa970c0b
https://doi.org/10.21203/rs.3.rs-1643401/v1
https://doi.org/10.21203/rs.3.rs-1643401/v1
Autor:
Vivien Low, Zhongchi Li, Ashley Laughney, Wenbing Jin, Noah Dephoure, Valbona Luga, Ethan Earlie, Bobak Parang, Chunjun Guo, Lewis Cantley, John Blenis
Publikováno v:
Cancer Research. 82:3175-3175
The importance of metabolic reprogramming in cancer has been long demonstrated by the association of systemic metabolic changes, such as aging, diet and exercise, with cancer outcomes. These systemic shifts, combined with local metabolic alterations
Autor:
Hidekiyo Harada, Paulo D Koeberle, Philip E. B. Nickerson, Nardos G. Tassew, Jason Charish, Jeffrey L. Wrana, Nahal Farhani, Philippe M D'Onofrio, Alireza P. Shabanzadeh, Brian Choi, Philippe P. Monnier, Valbona Luga, Ahmad Ellabban, Valerie A. Wallace
Publikováno v:
Cell Reports, Vol 20, Iss 1, Pp 99-111 (2017)
Summary Developing strategies that promote axonal regeneration within the injured CNS is a major therapeutic challenge, as axonal outgrowth is potently inhibited by myelin and the glial scar. Although regeneration can be achieved using the genetic de
Autor:
Thomas Kislinger, Yang W. Shao, Yasunori Okada, Masayuki Shimoda, Andreas Ludwig, Hartland W. Jackson, Laurie Ailles, Alison Aiken, Rama Khokha, Paul Waterhouse, Franz M. Hess, Jeffrey L. Wrana, Hui Fang, Takashi Ohtsuka, Christina Karamboulas, Simona Principe, Valbona Luga, Sam D. Molyneux
Publikováno v:
Nature Cell Biology. 16:889-901
Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cance
Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration
Autor:
Alicia Viloria-Petit, Jeffrey L. Wrana, Abiodun A. Ogunjimi, Marguerite Buchanan, Liang Zhang, Abdel Nasser Hosein, Mohammad R. Inanlou, Elaine Chiu, Valbona Luga, Mark Basik
Publikováno v:
Cell. 151(7):1542-1556
SummaryStroma in the tumor microenvironment plays a critical role in cancer progression, but how it promotes metastasis is poorly understood. Exosomes are small vesicles secreted by many cell types and enable a potent mode of intercellular communicat
Autor:
Melanie Pye, Rohit Bose, Jeffrey L. Wrana, Liang Zhang, Valbona Luga, Peter Ching, Masahiro Narimatsu, Bryan W. Miller, Liliana Attisano, Rui Sakuma, Luba Roncari
Publikováno v:
Cell. 137:295-307
SummaryPlanar cell polarity (PCP) is critical for morphogenesis in metazoans. PCP in vertebrates regulates stereocilia alignment in neurosensory cells of the cochlea and closure of the neural tube through convergence and extension movements (CE). Non
Autor:
Rohit Bose, Yongmei Liu, Zhong Liu, Barish Ozdamar, Jeffrey L. Wrana, Joanna Dembowy, Igor Jurisica, Mark D. Robinson, Kevin R. Brown, Fukiko Shinjo, Miriam Barrios-Rodiles, Valbona Luga, Ian W. Taylor, Yoshihide Hayashizaki, Rob Donovan, Natasa Przulj, Harukazu Suzuki
Publikováno v:
Science. 307:1621-1625
Signaling pathways transmit information through protein interaction networks that are dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-based mammalian interactome mapping), an automated high-throughput techno