Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Valasinas A"'
Publikováno v:
Journal of the Brazilian Chemical Society, Vol 10, Iss 4, Pp 334-340 (1999)
The binding of spermine (SPM), N¹,N12-bismethylspermine (BMS) and N¹,N12-bisethylspermine (BES) to tRNA Phe was studied using ¹H-NMR at 750 MHz. The polyamines were enriched in 13C at the 5-CH2 and 8-CH2 residues and the nuclear Overhauser enhance
Externí odkaz:
https://doaj.org/article/23107a0590df4aedab8ab91d9072e62d
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 1976 Feb 01. 273(924), 137-160.
Externí odkaz:
https://www.jstor.org/stable/2417457
Autor:
Valasinas, Aldonia, Reddy, Venodhar K, Blokhin, Andrei V, Basu, Hirak S, Bhattacharya, Subhra, Sarkar, Aparajita, Marton, Laurence J, Frydman, Benjamin
Publikováno v:
In Bioorganic & Medicinal Chemistry 2003 11(18):4121-4131
Autor:
Yi Huang, Judith Keen, Erin Hager, Renee Smith, Amy Hacker, Benjamin Frydman, Valasinas, Aldonia L., Reddy, Venodhar K., Marton, Laurence J., Casero, Robert A., Davidson, Nancy E.
Publikováno v:
Dimensions
Several polyamine analogues have efficacy against a variety of epithelial tumor models including breast cancer. Recently, a novel class of polyamine analogues designated as oligoamines has been developed. Here, we demonstrate that several representat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ede10c5e13bdec56ea6afbfae954a85
https://doi.org/10.1158/1541-7786.81.2.2
https://doi.org/10.1158/1541-7786.81.2.2
Autor:
Venodhar K. Reddy, Benjamin Frydman, Aparajita Sarkar, Hirak S. Basu, Laurence J. Marton, Andrei V. Blokhin, Aldonia Valasinas, Subhra Bhattacharya
Publikováno v:
Bioorganic & Medicinal Chemistry. 11:4121-4131
α N , ω N -bis(ethyl) octamine SL-11160, decamine SL-11159, dodecamine SL-11226, and tetradecamine SL-11175 were chemically synthesized. We called this class of compounds ‘oligoamines’. In these compounds, each –NH 2 + residue is separated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7514cbdd2c4354f079410ddd05e35d
https://doi.org/10.1016/s0968-0896(03)00453-x
https://doi.org/10.1016/s0968-0896(03)00453-x
Autor:
Aparajita Sarkar, Hirak S. Basu, Benjamin Frydman, Nick Kisiel, Yulia Maxuitenko, Subhra Bhattacharya, Aldonia Valasinas, Laurence J. Marton, Carl W. Porter, Venodhar K. Reddy
Publikováno v:
Cancer Chemotherapy and Pharmacology. 51:488-492
We tested the polyamine analog SL-11093 (3,8,13,18-tetraaza-10,11-[(E)-1,2-cyclopropyl]eicosane tetrahydrochloride) as an effective chemotherapeutic agent against human prostate cancer grown in nude mice.NCr-nu mice grafted with DU-145 human prostate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92a5b726ee5bdc39abd2a699fb283196
https://doi.org/10.1007/s00280-003-0598-8
https://doi.org/10.1007/s00280-003-0598-8
Autor:
Hirak S. Basu, Benjamin Frydman, Aldonia Valasinas, Aparajita Sarkar, Venodhar K. Reddy, Laurence J. Marton
Publikováno v:
Journal of Medicinal Chemistry. 44:390-403
Twelve analogues of 1N,14N-bisethylhomospermine (BE-4-4-4) with restricted conformations were synthesized in the search for cancer chemotherapeutic agents with higher cytotoxic activities and lower systemic toxicities than BE-4-4-4. The central butan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbfc6ef28965c5fe6504d3553ae6141
https://doi.org/10.1021/jm000309t
https://doi.org/10.1021/jm000309t
Autor:
Laurence J. Marton, Aldonia Valasinas, Hirak S. Basu, Benjamin Frydman, Venodhar K. Reddy, Aparajita Sarkar
Publikováno v:
Journal of Medicinal Chemistry. 44:404-417
From the results of our previous physicochemical studies of polyamine-nucleic acid interactions, we concluded that polyamine analogues in cisoidal conformation are capable of wrapping around the major groove of the double helix, of displacing natural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0db9fab0468031166e72c3540b867a
https://doi.org/10.1021/jm000310s
https://doi.org/10.1021/jm000310s
Autor:
Aldonia Valasinas, W. R. Waters, Michael J. Wannemuehler, Laurence J. Marton, Nigel Yarlett, Venudhar K. Reddy, James A. Harp, Benjamin Madison Frydman
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:2891-2894
Cryptosporidium parvuminfection of T-cell receptor alpha (TCR-α)-deficient mice results in a persistent infection. In this study, treatment with a polyamine analogue (SL-11047) preventedC. parvuminfection in suckling TCR-α-deficient mice and cleare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9498be9f5a3c9b1648348749ad3843
https://doi.org/10.1128/aac.44.10.2891-2894.2000
https://doi.org/10.1128/aac.44.10.2891-2894.2000
Publikováno v:
Expert Opinion on Therapeutic Patents. 9:1055-1068
Controlling cancer growth by interfering with its cellular uncontrolled DNA replication is a rational and sound approach for treating this disease. DNA is stabilised by the hydrogen bonding and electrostatic forces provided by DNA-bound polyamines. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37e69f62dc6ed1602d46b04645abbced
https://doi.org/10.1517/13543776.9.8.1055
https://doi.org/10.1517/13543776.9.8.1055