Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Valarie McCullar"'
Autor:
Jeffrey S. Miller, Bruce R. Blazar, Daniel J. Weisdorf, Sarah Cooley, Jakub Tolar, Michael R. Verneris, Angela Panoskaltsis-Mortari, Alexander J. Lenvik, Bin Zhang, Joerg Uwe Schmohl, Xianzheng Zhou, Valarie McCullar, Ron McElmurry, Martin Felices, Daniel A. Vallera
BiKE and TriKE selectively bind antigen expressing targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c1613539f70e5c17ea7a3560a26cd4
https://doi.org/10.1158/1078-0432.22457925
https://doi.org/10.1158/1078-0432.22457925
Autor:
Jeffrey S. Miller, Bruce R. Blazar, Daniel J. Weisdorf, Sarah Cooley, Jakub Tolar, Michael R. Verneris, Angela Panoskaltsis-Mortari, Alexander J. Lenvik, Bin Zhang, Joerg Uwe Schmohl, Xianzheng Zhou, Valarie McCullar, Ron McElmurry, Martin Felices, Daniel A. Vallera
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e98b70a7e5f9ef1c9112849b813b0a1
https://doi.org/10.1158/1078-0432.22457928
https://doi.org/10.1158/1078-0432.22457928
Autor:
Jeffrey S. Miller, Bruce R. Blazar, Daniel J. Weisdorf, Sarah Cooley, Jakub Tolar, Michael R. Verneris, Angela Panoskaltsis-Mortari, Alexander J. Lenvik, Bin Zhang, Joerg Uwe Schmohl, Xianzheng Zhou, Valarie McCullar, Ron McElmurry, Martin Felices, Daniel A. Vallera
Supplementary Figure 2. Studies of effector cells from normal donors indicate that NK cells proliferate moreso than T cells in response to TriKE, but T cells can expand.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6281ad8457e56cb0a45bf2508aa6517
https://doi.org/10.1158/1078-0432.22457916
https://doi.org/10.1158/1078-0432.22457916
Autor:
Jeffrey S. Miller, Sarah Cooley, Scott Wolchko, Bruce R. Blazar, Yenan T. Bryceson, Daniel Shoemaker, Stewart Abbot, Heinrich Schlums, Emily Taras, Dhifaf Sarhan, Peter Howard, Valarie McCullar, Phillip Dougherty, Katie Tuininga, Stacey Moreno, Svetlana Gaidarova, Paul Rogers, Betsy Rezner, Bin Zhang, Ryan Bjordahl, Bahram Valamehr, Frank Cichocki
This supplementary file contains Supplemental Figures 1-6. Supplemental Figure 1 shows that 7-day ex vivo culture of NK cells with IL-15 and 5 μM CHIR99021 leads to an increase in the frequencies of NK cells with heterogeneous adaptive NK cell pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::184b0fb84c9ccf8c3dc8884bfbd7510a
https://doi.org/10.1158/0008-5472.22414707
https://doi.org/10.1158/0008-5472.22414707
Autor:
Jeffrey S. Miller, Bruce R. Blazar, Daniel J. Weisdorf, Sarah Cooley, Jakub Tolar, Michael R. Verneris, Angela Panoskaltsis-Mortari, Alexander J. Lenvik, Bin Zhang, Joerg Uwe Schmohl, Xianzheng Zhou, Valarie McCullar, Ron McElmurry, Martin Felices, Daniel A. Vallera
Blocking studies show specificity of BiKEs and TriKEs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ad054b35b8b934e6235f05405a71c6f
https://doi.org/10.1158/1078-0432.22457922.v1
https://doi.org/10.1158/1078-0432.22457922.v1
Autor:
Jeffrey S. Miller, Bruce R. Blazar, Daniel J. Weisdorf, Sarah Cooley, Jakub Tolar, Michael R. Verneris, Angela Panoskaltsis-Mortari, Alexander J. Lenvik, Bin Zhang, Joerg Uwe Schmohl, Xianzheng Zhou, Valarie McCullar, Ron McElmurry, Martin Felices, Daniel A. Vallera
Supplementary Figure 1. To address the input of the IL-15 moiety on NK cell cytotoxicity, we compared the 161533 TriKE to equivalent molar concentrations of IL-15 or IL-15 plus 1633 BiKE. Activation markers were studied.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f00eff5e64bec17e6e829573cd9575
https://doi.org/10.1158/1078-0432.22457919.v1
https://doi.org/10.1158/1078-0432.22457919.v1
Autor:
Jeffrey S. Miller, Sarah Cooley, Scott Wolchko, Bruce R. Blazar, Yenan T. Bryceson, Daniel Shoemaker, Stewart Abbot, Heinrich Schlums, Emily Taras, Dhifaf Sarhan, Peter Howard, Valarie McCullar, Phillip Dougherty, Katie Tuininga, Stacey Moreno, Svetlana Gaidarova, Paul Rogers, Betsy Rezner, Bin Zhang, Ryan Bjordahl, Bahram Valamehr, Frank Cichocki
Maturation of human natural killer (NK) cells as defined by accumulation of cell-surface expression of CD57 is associated with increased cytotoxic character and TNF and IFNγ production upon target-cell recognition. Notably, multiple studies point to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85658b7abe87652af3f076650f779e3e
https://doi.org/10.1158/0008-5472.c.6509055.v1
https://doi.org/10.1158/0008-5472.c.6509055.v1
Autor:
Jeffrey S. Miller, Bruce R. Blazar, Daniel J. Weisdorf, Sarah Cooley, Jakub Tolar, Michael R. Verneris, Angela Panoskaltsis-Mortari, Alexander J. Lenvik, Bin Zhang, Joerg Uwe Schmohl, Xianzheng Zhou, Valarie McCullar, Ron McElmurry, Martin Felices, Daniel A. Vallera
Purpose: The effectiveness of NK cell infusions to induce leukemic remission is limited by lack of both antigen specificity and in vivo expansion. To address the first issue, we previously generated a bispecific killer engager (BiKE) containing singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df9fc30a460086cd5fcd8ddf89e1110
https://doi.org/10.1158/1078-0432.c.6523752
https://doi.org/10.1158/1078-0432.c.6523752
Autor:
Dhifaf Sarhan, Svetlana Gaidarova, Ryan Bjordahl, Valarie McCullar, Phillip Dougherty, Yenan T. Bryceson, Peter Howard, Frank Cichocki, Scott Wolchko, Katie Tuininga, Emily Taras, Stewart E Abbot, Jeffrey S. Miller, Bin Zhang, Sarah Cooley, Heinrich Schlums, Bahram Valamehr, Stacey K Moreno, Bruce R. Blazar, Betsy Rezner, Daniel Shoemaker, Paul Rogers
Publikováno v:
Cancer Research. 77:5664-5675
Maturation of human natural killer (NK) cells as defined by accumulation of cell-surface expression of CD57 is associated with increased cytotoxic character and TNF and IFNγ production upon target-cell recognition. Notably, multiple studies point to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3c3f5c4bd5fa9e74fbf60a17225bf3b
https://doi.org/10.1158/0008-5472.can-17-0799
https://doi.org/10.1158/0008-5472.can-17-0799
Autor:
Jessica M. Haverkamp, Robert Zeiser, Bruce R. Blazar, Vincenzo Bronte, Jenny P.-Y. Ting, Valarie McCullar, William J. Murphy, David H. Munn, Brent H. Koehn, Peter J. Murray, Jakub Tolar, Jeffrey S. Miller, Dmitry I. Gabrilovich, Petya Apostolova, Jonathan S. Serody, Willie June Brickey
Publikováno v:
Blood. 126:1621-1628
Myeloid-derived suppressor cells (MDSCs) are a naturally occurring immune regulatory population associated with inhibition of ongoing inflammatory responses. In vitro generation of MDSCs from bone marrow has been shown to enhance survival in an acute
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940d571fb36dc0c9a00c3c0325dd90f0
https://doi.org/10.1182/blood-2015-03-634691
https://doi.org/10.1182/blood-2015-03-634691