Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Valarie E. Vought"'
Publikováno v:
Glia. 63:1568-1580
Astrocytes produce and export the antioxidant glutathione (GSH). Previously, we found that interleukin-1β (IL-1β) enhanced the expression of astrocyte system xc (-) , the transporter that delivers the rate-limiting substrate for GSH synthesis-cyst(
Autor:
Venkatasubramanian Dharmarajan, Benny Howard, Gillian V. Kupakuwana, Stephen A. Shinsky, Michael S. Cosgrove, Stephen Swatkoski, Anamika Patel, Valarie E. Vought, Susan Viggiano, Robert J. Cotter, Kelsey E. Monteith, Kevin E. Namitz
Publikováno v:
The Journal of Biological Chemistry
Background: The MLL1 core complex mono- and dimethylates histone H3 lysine 4 (H3K4). Results: MLL1 automethylates a conserved cysteine residue in its active site cleft. Conclusion: MLL1 automethylation is inhibited by unmodified histone H3 but not by
Autor:
George M. Langford, D. William Provance, Michael S. Cosgrove, Valarie E. Vought, Torsten Wöllert, Ying Lung Lee, Anamika Patel, John A. Mercer
Publikováno v:
Journal of Biological Chemistry. 286:14352-14361
Myosin-Va (Myo5a) is a motor protein associated with synaptic vesicles (SVs) but the mechanism by which it interacts has not yet been identified. A potential class of binding partners are Rab GTPases and Rab3A is known to associate with SVs and is in
Publikováno v:
Journal of Biological Chemistry. 284:24242-24256
Transcription in eukaryotic genomes depends on enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of H3K4 methyltransferases and is frequently rearran
Publikováno v:
genesis. 44:412-418
In C. elegans, a population of proliferating germ cells is maintained via GLP-1/Notch signaling; in the absence of GLP-1 signaling, germ cells prematurely enter meiosis and differentiate. We previously identified ego (enhancer of glp-1) genes that pr
Autor:
Jessica Hauth, Valarie E. Vought, Xingyu She, Eleanor M. Maine, Thomas Ratliff, William G. Kelly
Publikováno v:
Current Biology. 15:1972-1978
SummaryDuring meiosis in C. elegans, unpaired chromosomes and chromosomal regions accumulate high levels of histone H3 lysine 9 dimethylation (H3K9me2), a modification associated with facultative heterochromatin assembly and the resulting transcripti
Publikováno v:
Genetics. 170:1121-1132
Caenorhabditis elegans EGO-1, a putative cellular RNA-directed RNA polymerase, promotes several aspects of germline development, including proliferation, meiosis, and gametogenesis, and ensures a robust response to RNA interference. In C. elegans, GL
Publikováno v:
Genetics. 168:817-830
In the Caenorhabditis elegans germline, proliferation is induced by Notch-type signaling. Entry of germ cells into meiosis is triggered by activity of the GLD-1 and GLD-2 pathways, which function redundantly to promote meiosis and/or inhibit prolifer
Publikováno v:
Glia. 63(9)
Astrocytes produce and export the antioxidant glutathione (GSH). Previously, we found that interleukin-1β (IL-1β) enhanced the expression of astrocyte system xc (-) , the transporter that delivers the rate-limiting substrate for GSH synthesis-cyst(
Autor:
Jay Shendure, Valarie E. Vought, Michael Hu, Sarah B. Ng, Stephen A. Shinsky, Michael S. Cosgrove, Michael J. Bamshad
Publikováno v:
Journal of molecular biology. 426(12)
The Mixed Lineage Leukemia-1 (MLL1) enzyme is a histone H3 lysine 4 (H3K4) monomethyltransferase and has served as a paradigm for understanding the mechanism of action of the human SET1 family of enzymes that include MLL1–4, and SET1d1a,b. Dimethyl