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Autor:
Rebecca S. Heist, Jennifer S. Temel, Lance Leopold, Waseem Khan, Jerry Fain, Lecia V. Sequist, Panos Fidias, Valari Brainerd, Julian R. Molina, Thomas J. Lynch, Bernard Chinnasami
Publikováno v:
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 5(10)
Introduction: AT-101 is an oral, pan Bcl-2 family protein inhibitor that has demonstrated activity in small cell lung cancer (SCLC) models. A phase I/II study was conducted combining AT-101 with topotecan in relapsed and refractory SCLC. Methods: An