Zobrazeno 1 - 10 of 1 180 pro vyhledávání: '"Valant C"'
1
Akademický článek
Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders.
Autor: Saito A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia., Alvi S; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia., Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia., Carbone SE; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia., Poole DP; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia.
Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Jul; Vol. 181 (14), pp. 2232-2246. Date of Electronic Publication: 2023 Jan 18.
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2
Akademický článek
Opportunities and challenges for the development of M 1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.
Autor: Nguyen HTM; Drug Discovery Biology, Monash University, Parkville, Melbourne, VIC, Australia.; Department of Biochemistry, Hanoi University of Pharmacy, Hanoi, Vietnam., van der Westhuizen ET; Drug Discovery Biology, Monash University, Parkville, Melbourne, VIC, Australia., Langmead CJ; Drug Discovery Biology, Monash University, Parkville, Melbourne, VIC, Australia.; Neuromedicines Discovery Centre, Monash University, Parkville, Melbourne, VIC, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash University, Parkville, Melbourne, VIC, Australia., Tobin AB; Centre for Translational Pharmacology, University of Glasgow, Glasgow, UK., Sexton PM; Drug Discovery Biology, Monash University, Parkville, Melbourne, VIC, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash University, Parkville, Melbourne, VIC, Australia., Christopoulos A; Drug Discovery Biology, Monash University, Parkville, Melbourne, VIC, Australia.; Neuromedicines Discovery Centre, Monash University, Parkville, Melbourne, VIC, Australia.; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash University, Parkville, Melbourne, VIC, Australia., Valant C; Drug Discovery Biology, Monash University, Parkville, Melbourne, VIC, Australia.; Neuromedicines Discovery Centre, Monash University, Parkville, Melbourne, VIC, Australia.
Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Jul; Vol. 181 (14), pp. 2114-2142. Date of Electronic Publication: 2022 Dec 04.
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3
Akademický článek
Importance of receptor expression in the classification of novel ligands at the M 2 muscarinic acetylcholine receptor.
Autor: Jiang Y; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Yeasmin M; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Gondin AB; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Burger WAC; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Publikováno v: British journal of pharmacology [Br J Pharmacol] 2024 Jul; Vol. 181 (14), pp. 2338-2350. Date of Electronic Publication: 2023 Jan 20.
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4
Inside Urban Charter Schools: Promising Practices and Strategies in Five High-Performing Schools,by K. Merseth with K. Cooper, J. Roberts, M. C. Tieken, J. Valant, & C. Wynne
Autor: Andrew D. Sparks
Publikováno v: Journal of School Choice. 3:417-422
Stories of successful urban charter schools are now regularly found in local and national newspapers, magazines, and news programs. Much like the “celebrity” teachers and administrators of the 1980...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b1f17f4d40db6597d05c33b1c12f7f7
https://doi.org/10.1080/15582150903442843
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5
Akademický článek
Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges.
Autor: Kaoullas MG; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, 3052, VIC, Parkville, Melbourne, Australia., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, 3052, VIC, Parkville, Melbourne, Australia., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, 3052, VIC, Parkville, Melbourne, Australia. Electronic address: Arthur.christopoulos@monash.edu., Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, 3052, VIC, Parkville, Melbourne, Australia. Electronic address: Celine.valant@monash.edu.
Publikováno v: Neuropharmacology [Neuropharmacology] 2024 Nov 01; Vol. 258, pp. 110092. Date of Electronic Publication: 2024 Jul 25.
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6
Akademický článek
Ligand-directed biased agonism at human histamine H 3 receptor isoforms across Gα i/o - and β-arrestin2-mediated pathways.
Autor: Rahman SN; Drug Discovery Biology and Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, 3052 VIC, Parkville, Melbourne, Australia; Amsterdam Institute for Molecular Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands. Electronic address: sabrina.rahman@sund.ku.dk., Imhaouran F; Amsterdam Institute for Molecular Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Leurs R; Amsterdam Institute for Molecular Life Sciences, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands., Christopoulos A; Drug Discovery Biology and Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, 3052 VIC, Parkville, Melbourne, Australia., Valant C; Drug Discovery Biology and Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, 3052 VIC, Parkville, Melbourne, Australia. Electronic address: celine.valant@monash.edu., Langmead CJ; Drug Discovery Biology and Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, 399 Royal Parade, 3052 VIC, Parkville, Melbourne, Australia. Electronic address: chris.langmead@monash.edu.
Publikováno v: Biochemical pharmacology [Biochem Pharmacol] 2024 Oct; Vol. 228, pp. 115988. Date of Electronic Publication: 2023 Dec 28.
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7
Akademický článek
Positive allosteric modulation of a GPCR ternary complex.
Autor: Burger WAC; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Draper-Joyce CJ; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.
Publikováno v: Science advances [Sci Adv] 2024 Sep 13; Vol. 10 (37), pp. eadp7040. Date of Electronic Publication: 2024 Sep 11.
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8
Akademický článek
Discovery of 2-Methyl-5-(1 H -pyrazol-4-yl)pyridines and Related Heterocycles as Promising M 4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders.
Autor: Liu B; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Thompson G; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Jörg M; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Barnes N; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Thal DM; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia.; Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Capuano B; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia., Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.; Australian Research Council Centre for Cryo-Electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria 3052, Australia., Scammells PJ; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.
Publikováno v: Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 13286-13304. Date of Electronic Publication: 2024 Jul 18.
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9
Akademický článek
Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice.
Autor: Liong S; Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia., Choy KHC; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia., De Luca SN; Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia., Liong F; Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia., Coward-Smith M; Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia., Oseghale O; Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia., Miles MA; Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia., Vlahos R; Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia., Valant C; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia., Nithianantharajah J; The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; Department of Florey Neuroscience, University of Melbourne, Melbourne, VIC, Australia. Electronic address: jess.n@florey.edu.au., Pantelis C; The Florey Institute of Neuroscience and Mental Health, Melbourne, VIC, Australia; Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne, Melbourne, VIC, Australia; Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia. Electronic address: cpant@unimelb.edu.au., Christopoulos A; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia; ARC Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia; Neuromedicines Discovery Centre, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, VIC, Australia. Electronic address: Arthur.christopoulos@monash.edu., Selemidis S; Centre for Respiratory Science and Health, School of Health and Biomedical Sciences, RMIT University, Bundoora, VIC, Australia. Electronic address: Stavros.selemidis@rmit.edu.au.
Publikováno v: Brain, behavior, and immunity [Brain Behav Immun] 2024 Aug; Vol. 120, pp. 488-498. Date of Electronic Publication: 2024 Jun 24.
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10
Role of conserved tyrosine lid residues in the activation of the M2 muscarinic acetylcholine receptor
Autor: Pham, V., Habben Jansen, M.C.C., Thompson, G., Heitman, L.H., Christopoulos, A., Thal, D.M., Valant, C.
The development of subtype-selective small molecule drugs for the muscarinic acetylcholine receptor (mAChR) family has been challenging. The design of more selective ligands can be improved by understanding the structure and function of key amino aci
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______202::6294cba0ac125d8f799dd4326a15043e
https://hdl.handle.net/1887/3631540
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