Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Val R. Marcy"'
Autor:
Sankar Chatterjee, John A. Gruner, Yin G. Lin, Brigitte Lesur, Lisa D. Aimone, Edward R. Bacon, Val R. Marcy
Publikováno v:
Chemical Biology & Drug Design. 81:429-432
In search of a next generation molecule to the novel wake-promoting agent modafinil, a series of aryl-heteroayl-derived wakefulness enhancing agents (in rats) was developed. From this work, compound 16 was separated into its enantiomers to profile th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53ba61430a469e50038848c3a564a471
https://doi.org/10.1111/cbdd.12083
https://doi.org/10.1111/cbdd.12083
Autor:
Robert L. Hudkins, Joanne R. Mathiasen, Reddeppa reddy Dandu, Lisa D. Aimone, Rita Raddatz, Val R. Marcy, Greg A. Hostetler, John A. Gruner, Caitlyn Benfield, Robert J. Bendesky
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:6362-6365
A series of pyridazinone-phenethylamine derivatives with moderate to low nanomolar affinity for rat and human H(3)R are described. These analogs exhibited excellent selectivity and metabolic stability, with acceptable rat pharmacokinetic properties.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5059cea68a269120cb488864e8573a91
https://doi.org/10.1016/j.bmcl.2011.08.104
https://doi.org/10.1016/j.bmcl.2011.08.104
Autor:
Kurt A. Josef, Allison L. Zulli, Lisa D. Aimone, Derek Dunn, Rita Raddatz, Jacquelyn A. Lyons, Ming Tao, Joanne R. Mathiasen, Reddeppa reddy Dandu, Thomas R. Bailey, Val R. Marcy, Babu G. Sundar, John A. Gruner, Edward R. Bacon, Robert L. Hudkins, Robert J. Bendesky, Yin-Guo Lin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:5493-5497
H3R structure–activity relationships on a novel class of pyridazin-3-one H3R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone core, central phenyl ring and linker led to the identification of molecules with excellent ta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a0a37d3e55238ac5c8227f7564e4b97
https://doi.org/10.1016/j.bmcl.2011.06.108
https://doi.org/10.1016/j.bmcl.2011.06.108
Autor:
Yin-Guo Lin, Maciej Gasior, Val R. Marcy, Michael J. Marino, John A. Gruner, Donna Bozyczko-Coyne
Publikováno v:
Sleep. 32:1425-1438
ALTHOUGH THE REGULATION OF SLEEP AND WAKE STATES IS BELIEVED TO INVOLVE BRAIN DOPAMINE (DA),1–3 ITS ROLE APPEARS COMPLEX. ACTIVATION of dopamine D1 receptors increases wake and reduces rapid eye movement sleep (REMS).4 The effects of activation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8b5a20f4e2c0e7699f5e11e73d4bdbe
https://doi.org/10.1093/sleep/32.11.1425
https://doi.org/10.1093/sleep/32.11.1425
Autor:
Derek Dunn, Mark A. Ator, John A. Gruner, Edward R. Bacon, Val R. Marcy, Mohamed Iqbal, Greg A. Hostetler, Yin Guo Lin, Lisa D. Aimone, Sankar Chatterjee, Bruce Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3751-3753
In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0bac540f89c51f0e0f859fbc63475c
https://doi.org/10.1016/j.bmcl.2012.04.031
https://doi.org/10.1016/j.bmcl.2012.04.031
Autor:
Brigitte, Lesur, Yin G, Lin, Val R, Marcy, Lisa D, Aimone, John, Gruner, Edward R, Bacon, Sankar, Chatterjee
Publikováno v:
Chemical biologydrug design. 81(3)
In search of a next generation molecule to the novel wake-promoting agent modafinil, a series of aryl-heteroayl-derived wakefulness enhancing agents (in rats) was developed. From this work, compound 16 was separated into its enantiomers to profile th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::439475864c0ba9612a44f0724aa8a805
https://pubmed.ncbi.nlm.nih.gov/23110414
https://pubmed.ncbi.nlm.nih.gov/23110414
Autor:
Robert L, Hudkins, Lisa D, Aimone, Thomas R, Bailey, Robert J, Bendesky, Reddeppa Reddy, Dandu, Derek, Dunn, John A, Gruner, Kurt A, Josef, Yin-Guo, Lin, Jacquelyn, Lyons, Val R, Marcy, Joanne R, Mathiasen, Babu G, Sundar, Ming, Tao, Allison L, Zulli, Rita, Raddatz, Edward R, Bacon
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(18)
H(3)R structure-activity relationships on a novel class of pyridazin-3-one H(3)R antagonists/inverse agonists are disclosed. Modifications of the pyridazinone core, central phenyl ring and linker led to the identification of molecules with excellent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::751b027788338fa7af0c76f12a30b863
https://pubmed.ncbi.nlm.nih.gov/21782432
https://pubmed.ncbi.nlm.nih.gov/21782432
Aurintricarboxylic Acid Protects Hippocampal Neurons from NMDA-and Ischemia-Induced Toxicity In Vivo
Autor:
Yonghua Zhao, Jill Roberts-Lewis, Val R. Marcy, Michael E. Lewis, Jeffry L. Vaught, Robert Siman
Publikováno v:
Journal of Neurochemistry. 61:378-381
The polymeric dye aurintricarboxylic acid (ATA) has been shown to protect various cell types from apoptotic cell death, reportedly through inhibition of a calcium-dependent endonuclease activity. Recent studies have indicated that there may be some c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54c972b58a136782be7388c735e50afa
https://doi.org/10.1111/j.1471-4159.1993.tb03583.x
https://doi.org/10.1111/j.1471-4159.1993.tb03583.x
Autor:
Dorothy G. Flood, Matthew S. Miller, Robert Siman, Richard DiRocco, Yuan Zhu, Richard W. Scott, Ratan V. Bhat, Pawel Dobrzanski, Patricia C. Contreras, Val R. Marcy
Although the interleukin-1β converting enzyme (ICE)/CED-3 family of proteases has been implicated recently in neuronal cell deathin vitroandin ovo, the role of specific genes belonging to this family in cell death in the nervous system remains unkno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d6b8b279a279cdda48cdddc218337f
https://europepmc.org/articles/PMC6578997/
https://europepmc.org/articles/PMC6578997/
