Výsledky vyhledávání - "Valérie Utard"

Identification of an N -acylated- D Arg-Leu-NH 2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia

Autor: Patrick Gizzi, Brigitte Ilien, Raphaëlle Quillet, Valérie Kugler, Frédéric Simonin, Valérie Simonneaux, Martine Schmitt, Frédéric Bihel, Khadija Elhabazi, Valérie Utard, Jo B. Henningsen, Armand Drieu la Rochelle, Séverine Schneider

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2021, 64 (11), pp.7555-7564. ⟨10.1021/acs.jmedchem.1c00256⟩

RFamide-related peptide-3 (RFRP-3) and neuropeptide FF (NPFF) target two different receptor subtypes called neuropeptide FF1 (NPFF1R) and neuropeptide FF2 (NPFF2R) that modulate several functions. However, the study of their respective role is severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc033340f680288639fd0c6e10518c96
https://hal.archives-ouvertes.fr/hal-03363456/document

Zobrazit plný text záznamu

Identification of an

Autor: Raphaëlle, Quillet, Séverine, Schneider, Valérie, Utard, Armand, Drieu la Rochelle, Khadija, Elhabazi, Jo Beldring, Henningsen, Patrick, Gizzi, Martine, Schmitt, Valérie, Kugler, Valérie, Simonneaux, Brigitte, Ilien, Frédéric, Simonin, Frédéric, Bihel

Publikováno v: Journal of medicinal chemistry. 64(11)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1e529d376378670e47de2cac05128375
https://pubmed.ncbi.nlm.nih.gov/34008968

Zobrazit plný text záznamu

A bifunctional biased mu opioid agonist-neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects

Autor: Steven Ballet, Armand Drieu la Rochelle, Pieter Mampuys, Valérie Utard, Frédéric Bihel, Séverine Schneider, Mariana Spetea, François Daubeuf, Karel Guillemyn, Tom Willemse, Maria Dumitrascuta, Nelly Frossard, Bert U. W. Maes, Raphaëlle Quillet, Charlotte Martin, Frédéric Simonin

Publikováno v: Pain
PAIN
PAIN, Elsevier, 2018, 159 (9), pp.1705-1718. ⟨10.1097/j.pain.0000000000001262⟩

Opioid analgesics, such as morphine, oxycodone and fentanyl, are the cornerstones for treating moderate to severe pain. However, upon chronic administration, their efficiency is limited by prominent side effects such as analgesic tolerance and depend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c453b72695ed1438ea7ad7e1b1b004b1
https://hdl.handle.net/10067/1506770151162165141

Zobrazit plný text záznamu

Neuropeptide FF receptors as novel targets for limbic seizure attenuation

Publikováno v: Neuropharmacology
Neuropharmacology, Elsevier, 2015, 95, pp.415-423. ⟨10.1016/j.neuropharm.2015.04.030⟩

Neuropeptide Y (NPY) is a well established anticonvulsant and first-in-class antiepileptic neuropeptide. In this study, the controversial role of NPY1 receptors in epilepsy was reassessed by testing two highly selective NPY1 receptor ligands and a mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d46bff75dcb54af8e1ab57527bb3707
https://doi.org/10.1016/j.neuropharm.2015.04.030

Zobrazit plný text záznamu

Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide

Autor: Hervé Maurin, Jinane Mouheiche, Emilie Audouard, John N. Wood, David Reiss, Yannick Goumon, Valérie Utard, Claire Gaveriaux-Ruff, Frédéric Simonin, Laurie-Anne Roeckel, Anne Robé

Publikováno v: Scientific Reports
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-11120-4⟩
Scientific Reports, Nature Publishing Group, 2017, 7 (1), ⟨10.1038/s41598-017-11120-4⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)

Opiates are potent analgesics but their clinical use is limited by side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). The Opiates produce analgesia and other adverse effects through activation of the mu opioid receptor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad10ae72f54c10a084ea33aca263cb4
https://hal.science/hal-03448002

Zobrazit plný text záznamu

RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents

Publikováno v: Neuropsychopharmacology (118), 188-198. (2017)
Neuropsychopharmacology
Neuropsychopharmacology, Nature Publishing Group, 2017, 118, pp.188-198. ⟨10.1016/j.neuropharm.2017.03.012⟩
Neuropharmacology
Neuropharmacology, Elsevier, 2017, 118, pp.188-198. ⟨10.1016/j.neuropharm.2017.03.012⟩
Neuropsychopharmacology, 2017, 118, pp.188-198. ⟨10.1016/j.neuropharm.2017.03.012⟩

Although opiates represent the most effective analgesics, their use in chronic treatments is associated with numerous side effects including the development of pain hypersensitivity and analgesic tolerance. We recently identified a novel orally activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba32ca33d553c23584c91375ed668b85
http://prodinra.inra.fr/record/388777

Zobrazit plný text záznamu

Bifunctional Peptide-Based Opioid Agonist–Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain

Autor: Nga N. Chung, Steven Ballet, Valérie Utard, Ewelina Rojewska, Joanna Mika, Barbara Przewlocka, Lucie Chevillard, Bruno Mégarbane, Peter W. Schiller, Pol Arranz-Gibert, Dirk Tourwé, Joanna Starnowska, Andrzej W. Lipkowski, Meritxell Teixidó, Karel Guillemyn, Jolanta Dyniewicz, Piotr Kosson, Camille Lagard, Frédéric Simonin

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2016, 59 (8), pp.3777-3792. ⟨10.1021/acs.jmedchem.5b01976⟩

Herein, the opioid pharmacophore H-Dmt-d-Arg-Aba-β-Ala-NH2 (7) was linked to peptide ligands for the nociceptin receptor. Combination of 7 and NOP ligands (e.g., H-Arg-Tyr-Tyr-Arg-Ile-Lys-NH2) led to binding affinities in the low nanomolar domain. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c53a7d0e9814ff45a7338641d4402e9
https://hal.archives-ouvertes.fr/hal-02993685/file/islandora_97262.pdf

Zobrazit plný text záznamu

Allosteric Functional Switch of Neurokinin A-Mediated Signaling at the Neurokinin NK2 Receptor: Structural Exploration

Autor: Jean Bourguignon, Celine Valant, Bernard Bucher, Jean Luc Galzi, Marcel Hibert, Valérie Utard, Emeline Maillet

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2009, 52 (19), pp.5999-6011. ⟨10.1021/jm900671k⟩

International audience; The neurokinin NK2 receptor is known to pre-exist in equilibrium between at least three states: resting-inactive, calcium-triggering, and cAMP-producing. Its endogeneous ligand, NKA, mainly induces the calcium response. Using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a7ea47843416908d168833a5d75643
https://doi.org/10.1021/jm900671k

Zobrazit plný text záznamu

A strategy to discover decoy chemokine ligands with an anti-inflammatory activity

Autor: Jean-Luc Galzi, Jacques Haiech, Pascal Villa, Dominique Bonnet, Valérie Utard, François Daubeuf, Dayana Abboud, Philippe Bernard, Nelly Frossard, Quoc Tuan Do, Marcel Hibert

Publikováno v: Scientific Reports
ResearcherID
Scientific Reports, Nature Publishing Group, 2015, 5, pp.14746. ⟨10.1038/srep14746⟩

Excessive signaling by chemokines has been associated with chronic inflammation or cancer, thus attracting substantial attention as promising therapeutic targets. Inspired by chemokine-clearing molecules shaped by pathogens to escape the immune syste

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e18f028441952749453bd8a16bf0ed
http://europepmc.org/articles/PMC4595804

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání