Výsledky vyhledávání - "Valérie Pouillon"

The gene INPPL1, encoding the lipid phosphatase SHIP2, is a candidate for type 2 diabetes in rat and man

Autor: André Bodson, Jens Behrends, G. Servais, Dominique Gauguier, Evelyne Marion, Pamela J. Kaisaki, Daubresse Jc, Claude Szpirer, J. Mockel, Cyril Gueydan, Jonathan C. Levy, Georges Krzentowski, Valérie Pouillon, Stéphane Schurmans, Véronique Kruys

Publikováno v: Scopus-Elsevier
Diabetes, 51

Genetic susceptibility to type 2 diabetes involves many genes, most of which are still unknown. The lipid phosphatase SHIP2 is a potent negative regulator of insulin signaling and sensitivity in vivo and is thus a good candidate gene. Here we report

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3155af37c1761a84281f3d6f79ec25e8
https://ora.ox.ac.uk/objects/uuid:92c3a867-8afa-473e-9daf-ff356eff3896

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The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system

Autor: Stéphane Schurmans, Christophe Erneux, Sylvie Janas, Eileen Pernot, Olivier Devuyst, Monique Jacoby, Renaud Beauwens, Bernard C. Rossier, Nicolas Markadieu, Stéphanie Gayral, Marianne Blockmans, Siew Chiat Cheong, Valérie Pouillon, Sara Terryn

Publikováno v: Pflügers Archiv : European Journal of Physiology, 462, 6, pp. 871-83
Pflügers Archiv : European Journal of Physiology, 462, 871-83
Pflügers Archiv-European Journal of Physiology; Vol 462
Pflügers Archiv-European Journal of Physiology

Inositol Inpp5k (or Pps, SKIP) is a member of the inositol polyphosphate 5-phosphatases family with a poorly characterized function in vivo. In this study, we explored the function of this inositol 5-phosphatase in mice and cells overexpressing the 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65be845847960fb20a5e0caaff42877e
https://doi.org/10.1007/s00424-011-1028-0

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Regulation of B cell survival, development and function by inositol 1,4,5-trisphosphate 3-kinase B (Itpkb)

Autor: Yoann Maréchal, Stéphane Schurmans, Valérie Pouillon

Publikováno v: Advances in Enzyme Regulation. 51:66-73

In mammals, Ins(1,4,5)P3, the well known calcium mobilization messenger, is phosphorylated in the cytosol at the 3-position of the inositol ring to yield Ins(1,3,4,5)P4 by Ins(1,4,5)P3 3-kinases A, B and C isoforms as well as by inositol polyphosphat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d57a37bf4f3fdc22de7e442c1967c461
https://doi.org/10.1016/j.advenzreg.2010.08.001

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Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells

Autor: Selena Polizzi, Séverine Quéant, Valérie Pouillon, Stéphane Schurmans, Yoann Maréchal

Publikováno v: Immunobiology. 216:103-109

Inositol 1,4,5-trisphosphate 3-kinase B (or Itpkb) and inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4), its reaction product, play an important role in the control of B lymphocyte fate and function in vivo. In order to investigate the fine mechan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17f92c372a2a8b5e192878d86f714d0
https://doi.org/10.1016/j.imbio.2010.03.012

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The absence of expression of the three isoenzymes of the inositol 1,4,5-trisphosphate 3-kinase does not prevent the formation of inositol pentakisphosphate and hexakisphosphate in mouse embryonic fibroblasts

Autor: Christophe Erneux, Alionka Bostan, Stéphane Schurmans, Xavier Pesesse, Valérie Pouillon, Alexandre Leyman

Publikováno v: Cellular Signalling. 19:1497-1504

The activation of phospholipase C leads to the formation of both I(1,4,5)P(3) and diacylglycerol (DAG). I(1,4,5)P(3) can be metabolized by dephosphorylation catalyzed by Type I I(1,4,5)P(3) 5-phosphatase and by enzymatic phosphorylation to various in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9efe6351dfa816681746063929d68cc
https://doi.org/10.1016/j.cellsig.2007.01.024

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Identification and subcellular distribution of endogenous Ins(1,4,5)P3 3-kinase B in mouse tissues

Autor: Christophe Erneux, Romana Hascakova-Bartova, George Banting, Céline Jacques, Colette Moreau, Valérie Dewaste, Stéphane Schurmans, Valérie Pouillon

Publikováno v: Biochemical and Biophysical Research Communications. 323:920-925

Inositol 1,4,5-trisphosphate 3-kinase (IP(3)-3K) catalyses the phosphorylation of inositol 1,4,5-trisphosphate to inositol 1,3,4,5-tetrakisphosphate. cDNAs encoding three mammalian isoforms have been reported and referred to as IP(3)-3KA, IP(3)-3KB,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a8223e9d2cb7a2b6bf437cd4f1bb577
https://doi.org/10.1016/j.bbrc.2004.08.152

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Inositol trisphosphate 3-kinase B is increased in human Alzheimer brain and exacerbates mouse Alzheimer pathology

Autor: Yonghui Jia, Valérie Pouillon, Jean Pierre Brion, Virginie Stygelbout, Stéphane Schurmans, H. Robert Luo, Kunie Ando, Christophe Erneux, Eva D’Amico, Charles Duyckaerts, Karelle Leroy

Publikováno v: Brain : a journal of neurology. 137(Pt 2)

ITPKB phosphorylates inositol 1,4,5-trisphosphate into inositol 1,3,4,5-tetrakisphosphate and controls signal transduction in various hematopoietic cells. Surprisingly, it has been reported that the ITPKB messenger RNA level is significantly increase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14ced2cb963b535370597ed7103299f
https://pubmed.ncbi.nlm.nih.gov/24401760

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Cloning and expression of a cDNA encoding human inositol 1,4,5-trisphosphate 3-kinase C

Autor: Valérie Pouillon, Colette Moreau, Christophe Erneux, Kazunaga Takazawa, Stephen B. Shears, Valérie Dewaste

Publikováno v: Biochemical Journal. 352:343-351

Inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase catalyses the phosphorylation of Ins(1,4,5)P(3) to Ins(1,3,4,5)P(4). cDNAs encoding two isoenzymes of Ins(1,4,5)P(3) 3-kinase (3-kinases A and B) have been described previously. In the present st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15970ca008ba95b597de2f4435793f82
https://doi.org/10.1042/bj3520343

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The Mouse SHIP2 (Inppl1) Gene: Complementary DNA, Genomic Structure, Promoter Analysis, and Gene Expression in the Embryo and Adult Mouse

Autor: Roberto Carrio, Jesús Merino, Serge Clément, Stéphane Schurmans, Jens Behrends, Valérie Pouillon

Publikováno v: Genomics. 62:260-271

SHIP2 is a new member of the inositol polyphosphate 5-phosphatase family showing homology to SHIP1. The structure of both enzymes is characterized by the presence of a 5' SH2 domain, a central catalytic domain, and a 3' proline-rich region. Recent re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745bffec987f7cad32579b55c008020c
https://doi.org/10.1006/geno.1999.5995

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Inositol 1,4,5-trisphosphate 3-kinase B (Itpkb) controls survival, proliferation and cytokine production in mouse peripheral T cells

Autor: Christophe Frippiat, Yoann Maréchal, Stéphane Schurmans, Christophe Erneux, Valérie Pouillon

Publikováno v: Advances in biological regulation. 53(1)

Mice genetically-deficient for the B isoform of the inositol 1,4,5-trisphosphate 3-kinase (or Itpkb) have a severe defect in thymocytes differentiation and thus lack peripheral T cells. In order to study the functional role of Itpkb in peripheral T c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffa9e27eb0d349a83a29ed3f60cfcc5
https://pubmed.ncbi.nlm.nih.gov/22981169

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