The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium

Autor: Chloé Maurizy, Claire Abeza, Bénédicte Lemmers, Monica Gabola, Ciro Longobardi, Valérie Pinet, Marina Ferrand, Conception Paul, Julie Bremond, Francina Langa, François Gerbe, Philippe Jay, Céline Verheggen, Nicola Tinari, Dominique Helmlinger, Rossano Lattanzio, Edouard Bertrand, Michael Hahne, Bérengère Pradet-Balade

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

RPAP3 is a subunit of the R2TP complex, a co-chaperone of HSP90, with substrate proteins involved in transcription, ribosome biogenesis, DNA repair and cell growth. Here the authors report that deletion of Rpap3 abrogates cell proliferation and homeo

Externí odkaz: https://doaj.org/article/a94c9c9c3f30427b974454354a00e279

Angiopoietin-2 is a direct transcriptional target of TAL1, LYL1 and LMO2 in endothelial cells.

Autor: Virginie Deleuze, Rawan El-Hajj, Elias Chalhoub, Christiane Dohet, Valérie Pinet, Philippe Couttet, Danièle Mathieu

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40484 (2012)

The two related basic helix-loop-helix, TAL1 and LYL1, and their cofactor LIM-only-2 protein (LMO2) are present in blood and endothelial cells. While their crucial role in early hematopoiesis is well established, their function in endothelial cells a

Externí odkaz: https://doaj.org/article/a6e243ce9cb242928f868d918de08632

In Lyl1-/- mice, adipose stem cell vascular niche impairment leads to premature development of fat tissues

Autor: Danièle Mathieu, Virginie Deleuze, Leila El Kebriti, Abid Hussain, Hulya Turali, Yaël Glasson, Nelly Pirot, Valérie Pinet

Publikováno v: Stem Cells / Stem Cells (Miamisburg)
Stem Cells / Stem Cells (Miamisburg), Alphamed Press, 2021, ⟨10.1002/stem.3286⟩

Lyl1 encodes a hematopoietic- and endothelial-specific bHLH transcription factor. Lyl1-deficient mice are viable, but they display mild hematopoietic and vascular defects. Specifically, LYL1 is required for the maturation and stabilization of blood v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4624b9d49f04c6d9d31e5435698cc335
https://hal.archives-ouvertes.fr/hal-03022048

The HSP90/R2TP assembly chaperone promotes cell proliferation in the intestinal epithelium

Autor: Marina Ferrand, Edouard Bertrand, Bénédicte Lemmers, Claire Abeza, Francina Langa, Conception Paul, Céline Verheggen, Valérie Pinet, Dominique Helmlinger, Bérengère Pradet-Balade, Rossano Lattanzio, Ciro Longobardi, Michael Hahne, Philippe Jay, François Gerbe, Monica Gabola, Julie Bremond, Chloé Maurizy, Nicola Tinari

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications
Nature Communications, 2021, 12 (1), pp.4810. ⟨10.1038/s41467-021-24792-4⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.4810. ⟨10.1038/s41467-021-24792-4⟩

The R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into multi-subunit complexes, yet its role in tissue homeostasis is unknown. Here, we generated conditional, inducible knock-out mice for Rpap3 to inactivate this core c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a684d2b37d0731f7bbb1ca0f5ddd57
https://pubmed.ncbi.nlm.nih.gov/36261420

The R2TP chaperone assembles cellular machineries in intestinal CBC stem cells and progenitors

Autor: Chloé Maurizy, Claire Abeza, Valérie Pinet, Marina Ferrand, Conception Paul, Julie Bremond, Francina Langa, François Gerbe, Philippe Jay, Céline Verheggen, Nicola Tinari, Dominique Helmlinger, Rossano Lattanzio, Edouard Bertrand, Michael Hahne, Bérengère Pradet-Balade

SummaryThe R2TP chaperone cooperates with HSP90 to integrate newly synthesized proteins into multi-subunit complexes, yet its role in tissue homeostasis is unknown. Here, we generated conditional, inducible knock-out mice forRpap3to inactivate this c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c130f414ad75b122ae800e5289d00327