Výsledky vyhledávání - "Valérie Navarro"

Immunoanalysis indicates that the sodium iodide symporter is not overexpressed in intracellular compartments in thyroid and breast cancers

Autor: Didier Marcellin, Sabine Lindenthal, Jacques Darcourt, Laurent Bellanger, F. Ettore, Isabelle Peyrottes, Valérie Navarro, Thierry Pourcher, Alejandro Ondo-Méndez, Robert Marsault

Publikováno v: European Journal of Endocrinology. 160:215-225

ObjectiveThe active transport of iodide into thyroid cells is mediated by the Na+/I− symporter (NIS) located in the basolateral membrane. Strong intracellular staining with anti-NIS antibodies has been reported in thyroid and breast cancers. Our in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707d97fdc65b03044022e5cb65517e8f
https://doi.org/10.1530/eje-08-0505

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Neurotensin receptor–1 and –3 complex modulates the cellular signaling of neurotensin in the HT29 cell line

Autor: Jean Mazella, Valérie Navarro, Jean-Pierre Vincent, Stéphane Martin

Publikováno v: Gastroenterology. 123:1135-1143

Background & Aims: The neuropeptide neurotensin (NT) exerts its intracellular effect by interacting with 3 different receptors. Two of these receptors (NTR1 and NTR2) belong to the G protein–coupled receptor family, whereas the third one (NTR3) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78957df1c5b34da81edd32abf8ec733e
https://doi.org/10.1053/gast.2002.36000

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Characterisation of the purified human sodium/iodide symporter reveals that the protein is mainly present in a dimeric form and permits the detailed study of a native C-terminal fragment

Autor: Olivier Averseng, Sylvaine Huc-Brandt, Didier Marcellin, Laurent Bellanger, Valérie Navarro, Patrick Hivin, Fanny Graslin, Cécile Basquin, Thierry Pourcher, Eric Quéméneur, Elisabeth Darrouzet

Publikováno v: Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2011, 1808 (1), pp.65-77. ⟨10.1016/j.bbamem.2010.08.013⟩
Biochimica et Biophysica Acta:Biomembranes, 2011, 1808 (1), pp.65-77. ⟨10.1016/j.bbamem.2010.08.013⟩

The sodium/iodide symporter is an intrinsic membrane protein that actively transports iodide into thyroid follicular cells. It is a key element in thyroid hormone biosynthesis and in the radiotherapy of thyroid tumours and their metastases. Sodium/io

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfaa6211f41dc2c99fe933c349fcdab1
https://pubmed.ncbi.nlm.nih.gov/20797386

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Comparison of expressed human and mouse sodium/iodide symporters reveals differences in transport properties and subcellular localization

Autor: Manal A. Dayem, Robert Marsault, Patrick Chang, Valérie Navarro, Patricia Carrier, Cécile Basquin, Thierry Pourcher, Sabine Lindenthal, Elisabeth Darrouzet, Sylvaine Huc

Publikováno v: Journal of Endocrinology
Journal of Endocrinology, BioScientifica, 2008, 197 (1), pp.95-109. ⟨10.1677/JOE-07-0455⟩
Journal of Endocrinology, 2008, 197 (1), pp.95-109. ⟨10.1677/JOE-07-0455⟩

The active transport of iodide from the bloodstream into thyroid follicular cells is mediated by the Na+/I− symporter (NIS). We studied mouse NIS (mNIS) and found that it catalyzes iodide transport into transfected cells more efficiently than human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab95d182f4451d5c00253e36f50bef39
https://hal.archives-ouvertes.fr/hal-02281985

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Internalization-dependent regulation of HT29 cell proliferation by neurotensin

Autor: Jean Mazella, Valérie Navarro, Stéphane Martin

Publikováno v: Peptides / Peptides (Fayetteville)
Peptides / Peptides (Fayetteville), 2006, 27 (10), pp.2502-7. ⟨10.1016/j.peptides.2006.04.028⟩

In this study, we have investigated the involvement of the internalization process induced by neurotensin (NT) on MAP kinases Erk1/2 activation, inositol phosphates (IP) accumulation and cell growth in the human colonic cancer cell line HT29. Reversi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93534bd4e00d46116ff350d0eafbef98
https://hal.science/hal-00171903

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From the molecular characterization of iodide transporters to the prevention of radioactive iodide exposure

Autor: Valérie Navarro, Thierry Pourcher, Robert Marsault, Jacques Darcourt, Sabine Lindenthal, Manal A. Dayem

Publikováno v: Biochimie. 88(11)

In the event of a nuclear reactor accident, the major public health risk will likely result from the release and dispersion of volatile radio-iodines. Upon body exposure and food ingestion, these radio-iodines are concentrated in the thyroid, resulti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8145fc4b34ee4de304a4a96f89a46c56
https://pubmed.ncbi.nlm.nih.gov/16905238

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Shedding of the luminal domain of the neurotensin receptor-3/sortilin in the HT29 cell line

Autor: Valérie Navarro, Jean Mazella, Jean-Pierre Vincent

Publikováno v: Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications, Elsevier, 2002, 298, pp.760-764

The neurotensin (NT) receptor-3/sortilin (NTR3) belongs to the new receptor family of VPS10P domain containing receptors. The NTR3 is expressed in all cancer cells on which NT activates cell growth and its cellular location is mainly intracellular wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b03559f212a454c05a18f5f979aea067
https://hal.archives-ouvertes.fr/hal-00091065

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Contulakin-G, an O-glycosylated invertebrate neurotensin

Autor: Elliott Richelson, William Low, David Griffin, Maren Watkins, Thomas Norberg, Baldomero M. Olivera, Jean Mazella, Julita S. Imperial, David R. Hillyard, Valérie Navarro, Karsten Schmidt, Lourdes J. Cruz, A. Grey Craig, John Dykert, Mateen Akhtar, Carl A. Hoeger

Publikováno v: The Journal of biological chemistry. 274(20)

We have purified contulakin-G, a 16-amino acid O-linked glycopeptide (pGlu-Ser-Glu-Glu-Gly-Gly-Ser-Asn-Ala-Thr-Lys-Lys-Pro-Tyr-Ile-Leu-OH, pGlu is pyroglutamate) from Conus geographus venom. The major glycosylated form of contulakin-G was found to in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfbe7cf6f48a1b54c9673f99f687afb
https://pubmed.ncbi.nlm.nih.gov/10318778

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