A Method to Study Migration and Invasion of Mouse Intestinal Organoids

Autor: Valérie M. Wouters, Ciro Longobardi, Jan Paul Medema

Publikováno v: Organoids, Vol 3, Iss 3, Pp 194-202 (2024)

Colorectal cancer (CRC) is the third most common cancer worldwide and it is the second leading cause of cancer death. In CRC, as in most cancers, the formation of metastasis through the migration and invasion of cancer cells to distant organs is asso

Externí odkaz: https://doaj.org/article/0e19b87ac7274bf8992237ad5c6f804d

Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia

Autor: Ester Gil Vazquez, Nadia Nasreddin, Gabriel N. Valbuena, Eoghan J. Mulholland, Hayley L. Belnoue-Davis, Holly R. Eggington, Ryan O. Schenck, Valérie M. Wouters, Pratyaksha Wirapati, Kathryn Gilroy, Tamsin R.M. Lannagan, Dustin J. Flanagan, Arafath K. Najumudeen, Sulochana Omwenga, Amy M.B. McCorry, Alistair Easton, Viktor H. Koelzer, James E. East, Dion Morton, Livio Trusolino, Timothy Maughan, Andrew D. Campbell, Maurice B. Loughrey, Philip D. Dunne, Petros Tsantoulis, David J. Huels, Sabine Tejpar, Owen J. Sansom, Simon J. Leedham

Publikováno v: Vasquez, E G, Nasreddin, N, Valbuena, G N, Mulholland, E J, Belnoue-Davis, H L, Eggington, H R, Schenck, R O, Wouters, V M, Wirapati, P, Gilroy, K, Lannagan, T R M, Flanagan, D J, Najumudeen, A K, Omwenga, S, McCorry, A M B, Easton, A, Koelzer, V H, East, J E, Morton, D, Trusolino, L, Maughan, T, Loughrey, M B, Dunne, P D, Tsantoulis, P, Huels, D J, Tejpar, S, Sansom, O J & Leedham, S J 2022, ' Dynamic and adaptive cancer stem cell population admixture in colorectal neoplasia ', Cell Stem Cell, vol. 29, no. 8, pp. 1213-1228.e8 . https://doi.org/10.1016/j.stem.2022.07.008
Cell stem cell, 29(8), 1213-1228.e8. Cell Press

Intestinal homeostasis is underpinned by LGR5+ve crypt-base columnar stem cells (CBCs), but following injury, dedifferentiation results in the emergence of LGR5-ve regenerative stem cell populations (RSCs), characterized by fetal transcriptional prof

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e8ae6065d6af4d48e6bf14034d2918
https://pure.qub.ac.uk/en/publications/ebe1f6bb-dff1-49d2-b1ec-2dd3b998e338

Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis

Autor: Rene Jackstadt, Colin W. Steele, Valérie M. Wouters, Colin Nixon, Andrew D. Campbell, Owen J. Sansom, Mamunur Rashid, Xabier Cortes-Lavaud, William H. Clark, Ömer H. Yilmaz, Jatin Roper, Joshua D.G. Leach, Timothy J. Kendall, Rachel A. Ridgway, Andrew V. Biankin, Simon T. Barry, Matthias Gunzer, Campbell S.D. Roxburgh, Craig Nourse, Sander R. van Hooff, Paul G. Horgan, Peter Bailey, David J. Adams, Jan Paul Medema, Jeroen O. Lohuis, Ann Hedley

Publikováno v: Cancer Cell
Cancer cell, 36(3), 319-336.e7. Cell Press
Jackstadt, R, van Hooff, S R, Leach, J D, Cortes-Lavaud, X, Lohuis, J O, Ridgway, R A, Wouters, V M, Roper, J, Kendall, T, Roxburgh, C S, Horgan, P G, Nixon, C, Nourse, C, Gunzer, M, Clark, W, Hedley, A, Yilmaz, O H, Rashid, M, Bailey, P, Biankin, A V, Campbell, A D, Adams, D J, Barry, S T, Steele, C W, Medema, J P & Sansom, O J 2019, ' Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis ', Cancer Cell . https://doi.org/10.1016/j.ccell.2019.08.003

Summary The metastatic process of colorectal cancer (CRC) is not fully understood and effective therapies are lacking. We show that activation of NOTCH1 signaling in the murine intestinal epithelium leads to highly penetrant metastasis (100% metastas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0bdb1c867eeb37915bfd8ccfa1639f
http://europepmc.org/articles/PMC6853173