Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Valérie Lorin"'
Autor:
Karunasinee Suphaphiphat, Delphine Desjardins, Valérie Lorin, Nastasia Dimant, Kawthar Bouchemal, Laetitia Bossevot, Maxence Galpin-Lebreau, Nathalie Dereuddre-Bosquet, Hugo Mouquet, Roger Le Grand, Mariangela Cavarelli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Passive immunization using broadly neutralizing antibodies (bNAbs) is investigated in clinical settings to inhibit HIV-1 acquisition due to the lack of a preventive vaccine. However, bNAbs efficacy against highly infectious cell-associated v
Externí odkaz:
https://doaj.org/article/9bc6be21ef194209bbd8bde4075f332a
Autor:
Luis M. Molinos-Albert, Valérie Lorin, Valérie Monceaux, Sylvie Orr, Asma Essat, Jérémy Dufloo, Olivier Schwartz, Christine Rouzioux, Laurence Meyer, Laurent Hocqueloux, Asier Sáez-Cirión, Hugo Mouquet, ANRS VISCONTI Study Group
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
A rare sub-population of people living with HIV-1 experience long-lasting viral remission after interrupting antiretroviral therapy and are considered post-treatment controllers. Here the authors characterise the humoral immune response to HIV-1 in a
Externí odkaz:
https://doaj.org/article/8c2bb6fda8ec43b2afd6cfd0349d774c
Autor:
Jérémy Dufloo, Cyril Planchais, Stéphane Frémont, Valérie Lorin, Florence Guivel-Benhassine, Karl Stefic, Nicoletta Casartelli, Arnaud Echard, Philippe Roingeard, Hugo Mouquet, Olivier Schwartz, Timothée Bruel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Broadly neutralizing antibodies (bNAbs) neutralize HIV-1 and exert Fc-dependent activities against infected cells. Here, Dufloo et al. show that bNAbs also block HIV-1 release by trapping viral particles at the surface of infected cells.
Externí odkaz:
https://doaj.org/article/977bb085667e46c7b122b4a7032ff1fb
Autor:
Marie Armani-Tourret, Zhicheng Zhou, Romain Gasser, Isabelle Staropoli, Vincent Cantaloube-Ferrieu, Yann Benureau, Javier Garcia-Perez, Mayte Pérez-Olmeda, Valérie Lorin, Bénédicte Puissant-Lubrano, Lambert Assoumou, Constance Delaugerre, Jean-Daniel Lelièvre, Yves Lévy, Hugo Mouquet, Guillaume Martin-Blondel, Jose Alcami, Fernando Arenzana-Seisdedos, Jacques Izopet, Philippe Colin, Bernard Lagane
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009526 (2021)
HIV-1 infects CD4 T lymphocytes (CD4TL) through binding the chemokine receptors CCR5 or CXCR4. CXCR4-using viruses are considered more pathogenic, linked to accelerated depletion of CD4TL and progression to AIDS. However, counterexamples to this para
Externí odkaz:
https://doaj.org/article/f6a51f49aafc435696f3d3a1a1dc8d6f
Autor:
Valérie Lorin, Anne Danckaert, Françoise Porrot, Olivier Schwartz, Philippe V. Afonso, Hugo Mouquet
Publikováno v:
mBio, Vol 11, Iss 5 (2020)
ABSTRACT HIV-1 can cross the blood-brain barrier (BBB) to penetrate the brain and infect target cells, causing neurocognitive disorders as a result of neuroinflammation and brain damage. Here, we examined whether antibodies targeting the HIV-1 envelo
Externí odkaz:
https://doaj.org/article/9f247b0ebedf4ff9954a82cb5fc1720f
Autor:
Julie Prigent, Annaëlle Jarossay, Cyril Planchais, Caroline Eden, Jérémy Dufloo, Ayrin Kök, Valérie Lorin, Oxana Vratskikh, Thérèse Couderc, Timothée Bruel, Olivier Schwartz, Michael S. Seaman, Oliver Ohlenschläger, Jordan D. Dimitrov, Hugo Mouquet
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2568-2581 (2018)
Human high-affinity antibodies to pathogens often recognize unrelated ligands. The molecular origin and the role of this polyreactivity are largely unknown. Here, we report that HIV-1 broadly neutralizing antibodies (bNAbs) are frequently polyreactiv
Externí odkaz:
https://doaj.org/article/94e93b8b4c694f2ab52f103c8961f5f0
Autor:
Cyril Planchais, Ayrin Kök, Alexia Kanyavuz, Valérie Lorin, Timothée Bruel, Florence Guivel-Benhassine, Tim Rollenske, Julie Prigent, Thierry Hieu, Thierry Prazuck, Laurent Lefrou, Hedda Wardemann, Olivier Schwartz, Jordan D. Dimitrov, Laurent Hocqueloux, Hugo Mouquet
Publikováno v:
Cell Reports, Vol 27, Iss 2, Pp 572-585.e7 (2019)
Summary: Mucosal immune responses to HIV-1 involve the recognition of the viral envelope glycoprotein (gp)160 by tissue-resident B cells and subsequent secretion of antibodies. To characterize the B cells “sensing” HIV-1 in the gut of infected in
Externí odkaz:
https://doaj.org/article/23b54c818eae44f5b3af42909e9f4363
Autor:
Timothée Bruel, Florence Guivel-Benhassine, Sonia Amraoui, Marine Malbec, Léa Richard, Katia Bourdic, Daniel Aaron Donahue, Valérie Lorin, Nicoletta Casartelli, Nicolas Noël, Olivier Lambotte, Hugo Mouquet, Olivier Schwartz
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
Broadly neutralizing antibodies (bNAbs) are promising as potential therapies targeting HIV-1 but their overall antiviral activity remains to be fully elucidated. Here the authors evaluate the ability of a panel of bNAbs to trigger antibody-dependent
Externí odkaz:
https://doaj.org/article/0c92443559f14621a72a3877677ac63a
Autor:
Olivier Leymarie, Grégory Jouvion, Pierre-Louis Hervé, Christophe Chevalier, Valérie Lorin, Jérôme Lecardonnel, Bruno Da Costa, Bernard Delmas, Nicolas Escriou, Ronan Le Goffic
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57894 (2013)
The PB1-F2 protein encoded by influenza A viruses can contribute to virulence, a feature that is dependent of its sequence polymorphism. Whereas PB1-F2 from some H1N1 viruses were shown to exacerbate the inflammatory response within the airways, the
Externí odkaz:
https://doaj.org/article/9b2a0d7452ab4be9ab97cb78af5e3ddc
Autor:
Valérie Lorin, Ignacio Fernández, Guillemette Masse-Ranson, Mélanie Bouvin-Pley, Luis M. Molinos-Albert, Cyril Planchais, Thierry Hieu, Gérard Péhau-Arnaudet, Dominik Hrebík, Giulia Girelli-Zubani, Oriane Fiquet, Florence Guivel-Benhassine, Rogier W. Sanders, Bruce D. Walker, Olivier Schwartz, Johannes F. Scheid, Jordan D. Dimitrov, Pavel Plevka, Martine Braibant, Michael S. Seaman, François Bontems, James P. Di Santo, Félix A. Rey, Hugo Mouquet
Publikováno v:
Journal of Experimental Medicine
Journal of Experimental Medicine, 2022, 219 (3), pp.e20212045. ⟨10.1084/jem.20212045⟩
Journal of experimental medicine, 219(3):e20212045. Rockefeller University Press
Journal of Experimental Medicine, 2022, 219 (3), pp.e20212045. ⟨10.1084/jem.20212045⟩
Journal of experimental medicine, 219(3):e20212045. Rockefeller University Press
International audience; Decrypting the B cell ontogeny of HIV-1 broadly neutralizing antibodies (bNAbs) is paramount for vaccine design. Here, we characterized IgA and IgG bNAbs of three distinct B cell lineages in a viremic controller, two of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fbdabc1785d2d76253a888d1c267a7
https://hal-pasteur.archives-ouvertes.fr/pasteur-03654254/file/jem_20212045.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-03654254/file/jem_20212045.pdf