Zobrazeno 1 - 10 of 20 pro vyhledávání: '"Valérie Large"'
1
Akademický článek
Comparison of the expression and activity of the lipogenic pathway in human and rat adipose tissue
Autor: Dominique Letexier, Claudie Pinteur, Valérie Large, Vincent Fréring, Michel Beylot
Publikováno v: Journal of Lipid Research, Vol 44, Iss 11, Pp 2127-2134 (2003)
Lipogenesis is considered less active in human than in rat adipose tissue. This could be explained by different nutritional conditions, namely high-carbohydrate (HCHO) diet in rats and high-fat (HF) diet in humans. Adipose tissue was sampled (postabs
Externí odkaz: https://doaj.org/article/593571cd03274a2d918ef8b00945b295
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2
Akademický článek
Hormone-sensitive lipase expression and activity in relation to lipolysis in human fat cells
Autor: Valérie Large, Peter Arner, Signy Reynisdottir, Jacques Grober, Vanessa Van Harmelen, Cecilia Holm, Dominique Langin
Publikováno v: Journal of Lipid Research, Vol 39, Iss 8, Pp 1688-1695 (1998)
Hormone-sensitive lipase (HSL) catalyzes the rate-limiting step in adipocyte lipolysis. The activity of HSL is thought to be primarily regulated by reversible phosphorylation. However, the regulation of HSL activity by pretranslational mechanisms has
Externí odkaz: https://doaj.org/article/2480a4b3323b4aa89f8876426185e4c4
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3
The Presence of a Catalytically Inactive Form of Hormone-Sensitive Lipase Is Associated With Decreased Lipolysis in Abdominal Subcutaneous Adipose Tissue of Obese Subjects
Autor: Dominique Larrouy, Dominique Langin, Cecilia Holm, Valérie Large, Hind Ray, Michel Beylot, Peter Arner
Publikováno v: Diabetes. 52:1417-1422
Hormone-sensitive lipase (HSL)-L is a key enzyme in the mobilization of fatty acids from triglyceride stores in adipocytes. A shorter variant of HSL (HSL-S) was detected in humans. This one is generated through in-frame skipping of exon 6 during the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61130233878a0df82007a79502b18df
https://doi.org/10.2337/diabetes.52.6.1417
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4
Various phosphodiesterase subtypes mediate the in vivo antilipolytic effect of insulin on adipose tissue and skeletal muscle in man
Autor: Staffan Enoksson, Eva Degerman, E Hagstrom-Toft, Peter Arner, Valérie Large
Publikováno v: Diabetologia. 41:560-568
The antilipolytic effect of insulin on human abdominal subcutaneous adipose tissue and skeletal muscle during local inhibition of cAMP-phosphodiesterases (PDEs) was investigated in vivo, by combining microdialysis with a euglycaemic, hyperinsulinaemi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ded377bfd4c0346036aa4b66db0207
https://doi.org/10.1007/s001250050947
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5
Human beta-2 adrenoceptor gene polymorphisms are highly frequent in obesity and associate with altered adipocyte beta-2 adrenoceptor function
Autor: Valérie Large, Per Eriksson, Lars Lannfelt, Fredrik Lönnqvist, Peter Arner, Signy Reynisdottir, L Hellström
Publikováno v: Journal of Clinical Investigation
Journal of Clinical Investigation, American Society for Clinical Investigation, 1997, 100 (12), pp.3005-3013. ⟨10.1172/JCI119854⟩
Karolinska Institutet
International audience; Catecholamines play a central role in the regulation of energy expenditure, in part by stimulating lipid mobilization through lipolysis in fat cells. The beta-2 adrenoceptor (BAR-2) is a major lipolytic receptor in human fat c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71ab59e4882d989e733fda35077c2cd3
https://doi.org/10.1172/jci119854
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6
The Q/E27 polymorphism in the beta2-adrenoceptor gene is associated with increased body weight and dyslipoproteinaemia involving triglyceride-rich lipoproteins
Autor: Per Eriksson, Peter Arner, Valérie Large, Anders Hamsten, Ewa Ehrenborg, G. Ruotolo, Josefin Skogsberg
Publikováno v: Karolinska Institutet
Journal of Internal Medicine
Journal of Internal Medicine, Wiley, 2000, 247 (6), pp.651-6
Ehrenborg E, Skogsberg J, Ruotolo G, Large V, Eriksson P, Arner P, Hamsten A (Karolinska Hospital, Stockholm, and Huddinge University Hospital, Huddinge, Sweden; and Istuto Scientifico H San Raffaele, Milano, Italy). The Q/E27 polymorphism in the β2
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f472b30d724a6e1335f22289a8c995a9
https://pubmed.ncbi.nlm.nih.gov/10886486
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7
Reduced hormone-sensitive lipase activity is not a major metabolic defect in Finnish FCHL families
Autor: Peter Arner, Signy Reynisdottir, Kati Ylitalo, Juha Vakkilainen, Päivi Pajukanta, Ilpo Nuotio, Kimmo Porkka, Valérie Large, Marja-Riitta Taskinen
The pathogenetic mechanisms behind familial combined hyperlipidemia (FCHL) are unknown. However, exaggerated postprandial lipemia and excessive serum free fatty acid (FFA) concentrations have drawn attention to altered lipid storage and lipolysis in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9f2ef51d266d9fd0a1266e39f5934e
https://hal.archives-ouvertes.fr/hal-01983572
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8
Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects
Autor: Dominique Langin, Peter Arner, Signy Reynisdottir, Mia Klannemark, Cecilia Holm, Katrin Fredby, Valérie Large
Publikováno v: Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 1999, 40 (11), pp.2059-66
Karolinska Institutet
Europe PubMed Central
Journal of Lipid Research, Vol 40, Iss 11, Pp 2059-2065 (1999)
Decreased lipolytic effect of catecholamines in adipose tissue has repeatedly been demonstrated in obesity and may be a cause of excess accumulation of body fat. However, the mechanisms behind this lipolysis defect are unclear. The role of hormone-se
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5b56fe9715426d8d7678229df7680d
https://pubmed.ncbi.nlm.nih.gov/10553009
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9
The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females
Autor: Valérie Large, Signy Reynisdottir, L Hellström, Peter Arner, Hans Wahrenberg
Publikováno v: Journal of internal medicine. 245(3)
Objectives. To investigate the role of a polymorphism in codon 27 (Gln27Glu) of the β2-adrenoceptor gene for obesity in males compared to previously investigated females with an association of this polymorphism to obesity. Design. Population-based s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d212db04db7800b10aeffb019277fa3c
https://pubmed.ncbi.nlm.nih.gov/10205587
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10
Hormone-sensitive lipase expression and activity in relation to lipolysis in human fat cells
Autor: Jacques Grober, Vanessa van Harmelen, Peter Arner, Dominique Langin, Signy Reynisdottir, Cecilia Holm, Valérie Large
Publikováno v: Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 1998, 39 (8), pp.1688-95
Journal of Lipid Research, Vol 39, Iss 8, Pp 1688-1695 (1998)
Karolinska Institutet
Europe PubMed Central
Hormone-sensitive lipase (HSL) catalyzes the rate-limiting step in adipocyte lipolysis. The activity of HSL is thought to be primarily regulated by reversible phosphorylation. However, the regulation of HSL activity by pretranslational mechanisms has
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6679e2ba0cd9de88d44f91ce1930ba
https://hal.archives-ouvertes.fr/hal-01983709
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