Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Valérie Landry"'
Autor:
Bruna Gioia, Francesca Ruggieri, Alexandre Biela, Valérie Landry, Pascal Roussel, Catherine Piveteau, Florence Leroux, Ruben C. Hartkoorn, Nicolas Willand
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17395 (2023)
Historically, natural products have played a major role in the development of antibiotics. Their complex chemical structures and high polarity give them advantages in the drug discovery process. In the broad range of natural products, sesquiterpene l
Externí odkaz:
https://doaj.org/article/5a89e68bc6d74619afa0300946749f17
Autor:
Julie Charton, Clara Maillard, Chau Phi Dinh, Adrien Herledan, Florence Leroux, Catherine Piveteau, Benoit Deprez, Isabelle Duplan, Nicolas Kraupner, Nathalie Hennuyer, Xiaoan Wen, Rebecca Deprez-Poulain, Damien Bosc, Sandrine Warenghem, Bart Staels, Valérie Landry
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2021, pp.113982. ⟨10.1016/j.ejmech.2021.113982⟩
European Journal of Medicinal Chemistry, Elsevier, 2021, pp.113982. ⟨10.1016/j.ejmech.2021.113982⟩
European Journal of Medicinal Chemistry, 2021, pp.113982. ⟨10.1016/j.ejmech.2021.113982⟩
European Journal of Medicinal Chemistry, Elsevier, 2021, pp.113982. ⟨10.1016/j.ejmech.2021.113982⟩
International audience; Insulin degrading enzyme (IDE) is a zinc metalloprotease that cleaves numerous substrates among which amyloid-β and insulin. It has been linked through genetic studies to the risk of type-2 diabetes (T2D) or Alzheimer's disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ed5fe0bfb1f46856b4bc660d9fb3a7
https://hal.science/hal-03430475
https://hal.science/hal-03430475
Autor:
Florence Leroux, Julie Charton, François-Xavier Cantrelle, Xavier Hanoulle, Sandrine Belouzard, Danai Moschidi, Isabelle Landrieu, Lucile Brier, Jean Dubuisson, Valérie Landry, Emmanuelle Boll, Benoit Deprez, Frédérique Dewitte
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie International Edition, In press, 60 (48), pp.25428-25435. ⟨10.1002/anie.202109965⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, In press, 60 (48), pp.25428-25435. ⟨10.1002/anie.202109965⟩
Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition, In press, 60 (48), pp.25428-25435. ⟨10.1002/anie.202109965⟩
Angewandte Chemie International Edition, Wiley-VCH Verlag, In press, 60 (48), pp.25428-25435. ⟨10.1002/anie.202109965⟩
Angewandte Chemie (International Ed. in English)
The main protease (3CLp) of the SARS‐CoV‐2, the causative agent for the COVID‐19 pandemic, is one of the main targets for drug development. To be active, 3CLp relies on a complex interplay between dimerization, active site flexibility, and allo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9f57c9062d78db7309da0eef562a88
https://hal.science/hal-03363607
https://hal.science/hal-03363607
Autor:
Valérie Landry, Valentin Guillaume, Julie Charton, Florence Leroux, Wei-Jen Tang, Terence Beghyn, Sandrine Warenghem, Wenguang G. Liang, Sarah Urata, Virginie Pottiez, Paul Hermant, Li Sheng, Rebecca Deprez-Poulain, Damien Bosc, Adrien Herledan, Benoit Deprez
Publikováno v:
European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, 2019, 179, pp.557-566. ⟨10.1016/j.ejmech.2019.06.057⟩
European Journal of Medicinal Chemistry, Elsevier, 2019, 179, pp.557-566. ⟨10.1016/j.ejmech.2019.06.057⟩
Eur J Med Chem
European Journal of Medicinal Chemistry, 2019, 179, pp.557-566. ⟨10.1016/j.ejmech.2019.06.057⟩
European Journal of Medicinal Chemistry, Elsevier, 2019, 179, pp.557-566. ⟨10.1016/j.ejmech.2019.06.057⟩
Eur J Med Chem
International audience; Insulin-degrading enzyme, IDE, is a metalloprotease implicated in the metabolism of key peptides such as insulin, glucagon, β-amyloid peptide. Recent studies have pointed out its broader role in the cell physiology. In order
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d8372949902200aa76e63f083a7335
https://hal.science/hal-03243182
https://hal.science/hal-03243182
Autor:
Céline Crauste, Priscille Brodin, Stéphane Audebert, Vincent Delorme, Jean-Marie Galano, Matthieu Pophillat, Anaïs Bénarouche, Valérie Landry, Alexandre Guy, Thierry Durand, Phuong Chi Nguyen, Jean-François Cavalier, Luc Camoin, Stéphane Canaan
Publikováno v:
Bioorganic Chemistry
Bioorganic Chemistry, 2018, 81, pp.414-424. ⟨10.1016/j.bioorg.2018.08.025⟩
Bioorganic Chemistry, Elsevier, 2018, 81, pp.414-424. ⟨10.1016/j.bioorg.2018.08.025⟩
Bioorganic Chemistry, 2018, 81, pp.414-424. ⟨10.1016/j.bioorg.2018.08.025⟩
Bioorganic Chemistry, Elsevier, 2018, 81, pp.414-424. ⟨10.1016/j.bioorg.2018.08.025⟩
International audience; A set of 19 oxadiazolone (OX) derivatives have been investigated for their antimycobacterial activity against two pathogenic slow-growing mycobacteria, Mycobacterium marinum and Mycobacterium bovis BCG, and the avirulent Mycob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b05c1092d88d6aca62a70db5830dcc9
https://amu.hal.science/hal-01875577/document
https://amu.hal.science/hal-01875577/document
Autor:
Hélène Gras-Masse, Jamal Elbakali, Cyril Ronco, Nathalie Hennuyer, Marion Gauriot, Julie Charton, Wenguang G. Liang, Xiaoan Wen, Antoine Heninot, Florence Leroux, Julie Dumont, Jane Totobenazara, Valérie Landry, Xavier Marechal, Wei-Jen Tang, Adrien Herledan, Virginie Pottiez, Bart Staels, Rebecca Deprez-Poulain, Damien Bosc, Benoit Deprez
Publikováno v:
European Journal of Medicinal Chemistry. 90:547-567
Insulin degrading enzyme (IDE) is a zinc metalloprotease that degrades small amyloid peptides such as amyloid-β and insulin. So far the dearth of IDE-specific pharmacological inhibitors impacts the understanding of its role in the physiopathology of
Autor:
Vadim Makarov, Antonio Carta, Maria Rosalia Pasca, Vincent Delorme, Gaëlle S. Kolly, Claudia Binda, Stewart T. Cole, Alessio Porta, Florence Pojer, Ramakrishna Gadupudi, Priscille Brodin, Ana Luisa de Jesus Lopes Ribeiro, Giuseppe Zanoni, Neeraj Dhar, Laurent R. Chiarelli, Valérie Landry, Svetlana Savina, Rosaria Luciani, Edda De Rossi, Davide Salvatore Francesco Farina, Giorgia Mori, Maria Paola Costi, Stefania Ferrari, Elisabetta Molteni, Alberto Venturelli, Giovanna Riccardi, João Neres, Puneet Saxena, Ruben C. Hartkoorn
Publikováno v:
ACS Chemical Biology. 10:705-714
Phenotypic screening of a quinoxaline library against replicating Mycobacterium tuberculosis led to the identification of lead compound Ty38c (3-((4-methoxybenzyl)amino)-6-(trifluoromethyl)quinoxaline-2-carboxylic acid). With an MIC99 and MBC of 3.1
Autor:
Marion Gauriot, Virginie Pottiez, Valérie Landry, Malika Hamdane, Nathalie Hennuyer, Wei-Jen Tang, Julie Charton, Qing Guo, Olivier Sperandio, Bart Staels, Julie Dumont, Florence Leroux, Rebecca Deprez-Poulain, Xavier Marechal, Luc Buée, Marion Flipo, Benoit Deprez
Insulin degrading enzyme (IDE) is a highly conserved zinc metalloprotease that is involved in the clearance of various physiologically peptides like amyloid-beta and insulin. This enzyme has been involved in the physiopathology of diabetes and Alzhei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a2edfeab3feb6e614eabba39bb8e78f
https://europepmc.org/articles/PMC4128174/
https://europepmc.org/articles/PMC4128174/
Autor:
Alain R. Baulard, Raffaella Iantomasi, Nathalie Deboosere, Valérie Landry, Romain Veyron-Churlet, Christophe J. Queval, Vincent Delorme, Priscille Brodin, Ok-Ryul Song
Publikováno v:
Journal of visualized experiments : JoVE. (83)
Despite the availability of therapy and vaccine, tuberculosis (TB) remains one of the most deadly and widespread bacterial infections in the world. Since several decades, the sudden burst of multi- and extensively-drug resistant strains is a serious
Autor:
Sophie Girault, Valérie Landry, Marie-Ange Debreu, Louis Maes, Jean-François Dubremetz, Christian Sergheraert, Elisabeth Davioud-Charvet
Publikováno v:
Bioorganic & Medicinal Chemistry. 9:837-846
In order to optimise the activity of bis(2-aminodiphenylsulfides) upon trypanothione reductase (TR) from Trypanosoma cruzi , a new series of bis(2-aminodiphenylsulfides) possessing three side chains was synthesized. Various moieties were introduced a