Výsledky vyhledávání - "Valérie Huteau"

Akademický článek

New Chemical Probe Targeting Bacterial NAD Kinase

Autor: David A. Clément, Clarisse Leseigneur, Muriel Gelin, Dylan Coelho, Valérie Huteau, Corinne Lionne, Gilles Labesse, Olivier Dussurget, Sylvie Pochet

Publikováno v: Molecules, Vol 25, Iss 21, p 4893 (2020)

Nicotinamide adenine dinucleotide (NAD) kinases are essential and ubiquitous enzymes involved in the tight regulation of NAD/nicotinamide adenine dinucleotide phosphate (NADP) levels in many metabolic pathways. Consequently, they represent promising

Externí odkaz: https://doaj.org/article/44ffd8ae00fd408e8ebb615e36417972

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Structure‐based design, synthesis and biological evaluation of a NAD+ analogue targeting Pseudomonas aeruginosa NAD kinase

Autor: Rahila Rahimova, Pauline Nogaret, Valérie Huteau, Muriel Gelin, David A. Clément, Gilles Labesse, Sylvie Pochet, Anne‐Béatrice Blanc‐Potard, Corinne Lionne

Publikováno v: FEBS Journal
FEBS Journal, 2023, 290 (2), pp.482-501. ⟨10.1111/febs.16604⟩

International audience; Multi-drug resistance is a major public health problem that requires the urgent development of new antibiotics and therefore the identification of novel bacterial targets. The activity of nicotinamide adenine dinucleotide kina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4db5351ff34c7b5c26f7b045216087
https://hal.science/hal-03765406

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Synthesis and structure-activity relationship studies of original cyclic diadenosine derivatives as nanomolar inhibitors of NAD kinase from pathogenic bacteria

Autor: David A. Clément, Muriel Gelin, Clarisse Leseigneur, Valérie Huteau, Lou Mondange, Jean-Luc Pons, Olivier Dussurget, Corinne Lionne, Gilles Labesse, Sylvie Pochet

Publikováno v: European journal of medicinal chemistry. 246

Nicotinamide adenine dinucleotide kinases (NAD kinases) are essential and ubiquitous enzymes involved in the production of NADP(H) which is an essential cofactor in many metabolic pathways. Targeting NAD kinase (NADK), a rate limiting enzyme of NADP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f95eb760a9086f91c0e0e90ccf232fe
https://pubmed.ncbi.nlm.nih.gov/36455355

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Structure-based design, synthesis and biological evaluation of a NAD

Autor: Rahila, Rahimova, Pauline, Nogaret, Valérie, Huteau, Muriel, Gelin, David A, Clément, Gilles, Labesse, Sylvie, Pochet, Anne-Béatrice, Blanc-Potard, Corinne, Lionne

Publikováno v: The FEBS journalReferences.

Multidrug resistance is a major public health problem that requires the urgent development of new antibiotics and therefore the identification of novel bacterial targets. The activity of nicotinamide adenine dinucleotide kinase, NADK, is essential in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d4954113025d152292308e178151bbd
https://pubmed.ncbi.nlm.nih.gov/36036789

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From Substrate to Fragments to Inhibitor Active

Autor: Muriel, Gelin, Julie, Paoletti, Marie-Anne, Nahori, Valérie, Huteau, Clarisse, Leseigneur, Grégory, Jouvion, Laurence, Dugué, David, Clément, Jean-Luc, Pons, Liliane, Assairi, Sylvie, Pochet, Gilles, Labesse, Olivier, Dussurget

Publikováno v: ACS infectious diseases. 6(3)

Antibiotic resistance is a worldwide threat due to the decreasing supply of new antimicrobials. Novel targets and innovative strategies are urgently needed to generate pathbreaking drug compounds. NAD kinase (NADK) is essential for growth in most bac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9a31945eb5a771ce9f57de5487695d70
https://pubmed.ncbi.nlm.nih.gov/32017533

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8-Thioalkyl-adenosine derivatives inhibit Listeria monocytogenes NAD kinase through a novel binding mode

Autor: Julie Paoletti, Gilles Labesse, Olivier Dussurget, Marie Anne Nahori, Liliane Assairi, Sylvie Pochet, Muriel Gelin, Valérie Huteau

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2016, 124, pp.1041-1056. ⟨10.1016/j.ejmech.2016.10.033⟩
European Journal of Medicinal Chemistry, 2016, 124, pp.1041-1056. ⟨10.1016/j.ejmech.2016.10.033⟩

Increased resistance of pathogens to existing antibiotics necessitates the search for novel targets to develop potent antimicrobials. Biosynthetic pathways of several cofactors important for bacterial growth, such as nicotinamide adenine dinucleotide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e165d3eae566bd9b213507978bbd048a
https://doi.org/10.1016/j.ejmech.2016.10.033

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Phosphorylcholine−Carbohydrate− Protein Conjugates Efficiently Induce Hapten-Specific Antibodies Which Recognize BothStreptococcuspneumoniaeandNeisseriameningitidis: A Potential Multitarget Vaccine against Respiratory Infections

Autor: Pierre Lafaye, Muhamed-Kheir Taha, Joël Ughetto-Monfrin, Sylvie Bay, René Pires, Valérie Huteau, Maria Leticia Zarantonelli, Patrick England

Publikováno v: Journal of Medicinal Chemistry. 47:3916-3919

Phosphorylcholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria meningitidis. We designed a synthetic hapten comprising ChoP and part of its native carrier structur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f80cfa20001807d56043298d42afda9
https://doi.org/10.1021/jm040783p

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ChemInform Abstract: Synthesis of Novel 9-Aryl and Heteroarylpurine Derivatives via Copper Mediated Coupling Reaction

Autor: L. Morellato, Valérie Huteau, Sylvie Pochet

Publikováno v: ChemInform. 45

A series of 9-(hetero)arylpurine derivatives has been prepared through N-arylation of 6-chloropurine with boronic acids in the presence of copper(II) acetate. Screening reaction conditions in terms of bases and solvents led to the successful coupling

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dabb4fb4fb8dcb3b83f802368a7966e
https://doi.org/10.1002/chin.201430171

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Synthesis of novel 9-aryl and heteroarylpurine derivatives via copper mediated coupling reaction

Autor: L. Morellato, Sylvie Pochet, Valérie Huteau

Publikováno v: Tetrahedron Letters
Tetrahedron Letters, 2014, 55 (9), pp.1625-1627. ⟨10.1016/j.tetlet.2014.01.091⟩
Tetrahedron Letters, Elsevier, 2014, 55 (9), pp.1625-1627. ⟨10.1016/j.tetlet.2014.01.091⟩

International audience; A series of 9-(hetero)arylpurine derivatives has been prepared through N-arylation of 6-chloropurine with boronic acids in the presence of copper(II) acetate. Screening reaction conditions in terms of bases and solvents led to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc9ec29a5af2e825f1fa7ab0f774244e
https://hal.science/hal-01968382

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A SERS probe for adenyl residues available for intermolecular interactions. Part II?Reactive adenyl sites in highly diluted DNA

Autor: Tam Huynh-Dinh, Valérie Huteau, Lydie Grajcar, Marie-Hélène Baron

Publikováno v: Journal of Raman Spectroscopy. 32:1037-1045

Surface-enhanced Raman spectroscopy (SERS) with an (Ag)n+ substrate detects picomoles of adenyl residues (Ayl) in a mildly salted aqueous medium (10−2M NaCl). Chloride binding to Ayl enhances the Ayl affinity for silver. The SER spectral profile pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52158290639372e257150b15b62c3f43
https://doi.org/10.1002/jrs.796

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